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Probabilistic Mixture Models Improve Calibration of Panel-derived Tumor Mutational Burden in the Context of both Tumor-normal and Tumor-only Sequencing
BACKGROUND: Tumor mutational burden (TMB) has been investigated as a biomarker for immune checkpoint blockade (ICB) therapy. Increasingly, TMB is being estimated with gene panel–based assays (as opposed to full exome sequencing) and different gene panels cover overlapping but distinct genomic coordi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for Cancer Research
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044680/ https://www.ncbi.nlm.nih.gov/pubmed/36999044 http://dx.doi.org/10.1158/2767-9764.CRC-22-0339 |