The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized Burkholderia pseudomallei

Burkholderia pseudomallei, the causative agent of the disease melioidosis, has been isolated from the environment in 45 countries. The treatment of melioidosis is complex, requiring lengthy antibiotic regimens, which can result in the relapse of the disease following treatment cessation. It is impor...

Descripción completa

Detalles Bibliográficos
Autores principales: Nelson, Michelle, Barnes, Kay B., Davies, Carwyn H., Cote, Christopher K., Meinig, J. Matthew, Biryukov, Sergei S., Dyer, David N., Frick, Ondraya, Heine, Henry, Pfefferle, Denise A., Horstman-Smith, Amanda, Barbaras, Julie, Harding, Sarah V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044689/
https://www.ncbi.nlm.nih.gov/pubmed/36978372
http://dx.doi.org/10.3390/antibiotics12030506
_version_ 1784913407900647424
author Nelson, Michelle
Barnes, Kay B.
Davies, Carwyn H.
Cote, Christopher K.
Meinig, J. Matthew
Biryukov, Sergei S.
Dyer, David N.
Frick, Ondraya
Heine, Henry
Pfefferle, Denise A.
Horstman-Smith, Amanda
Barbaras, Julie
Harding, Sarah V.
author_facet Nelson, Michelle
Barnes, Kay B.
Davies, Carwyn H.
Cote, Christopher K.
Meinig, J. Matthew
Biryukov, Sergei S.
Dyer, David N.
Frick, Ondraya
Heine, Henry
Pfefferle, Denise A.
Horstman-Smith, Amanda
Barbaras, Julie
Harding, Sarah V.
author_sort Nelson, Michelle
collection PubMed
description Burkholderia pseudomallei, the causative agent of the disease melioidosis, has been isolated from the environment in 45 countries. The treatment of melioidosis is complex, requiring lengthy antibiotic regimens, which can result in the relapse of the disease following treatment cessation. It is important that novel therapies to treat infections with B. pseudomallei be assessed in appropriate animal models, and discussions regarding the different protocols used between laboratories are critical. A ‘deep dive’ was held in October 2020 focusing on the use of the BALB/c mouse model and the inhalational route of infection to evaluate new antibiotic therapies.
format Online
Article
Text
id pubmed-10044689
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100446892023-03-29 The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized Burkholderia pseudomallei Nelson, Michelle Barnes, Kay B. Davies, Carwyn H. Cote, Christopher K. Meinig, J. Matthew Biryukov, Sergei S. Dyer, David N. Frick, Ondraya Heine, Henry Pfefferle, Denise A. Horstman-Smith, Amanda Barbaras, Julie Harding, Sarah V. Antibiotics (Basel) Perspective Burkholderia pseudomallei, the causative agent of the disease melioidosis, has been isolated from the environment in 45 countries. The treatment of melioidosis is complex, requiring lengthy antibiotic regimens, which can result in the relapse of the disease following treatment cessation. It is important that novel therapies to treat infections with B. pseudomallei be assessed in appropriate animal models, and discussions regarding the different protocols used between laboratories are critical. A ‘deep dive’ was held in October 2020 focusing on the use of the BALB/c mouse model and the inhalational route of infection to evaluate new antibiotic therapies. MDPI 2023-03-03 /pmc/articles/PMC10044689/ /pubmed/36978372 http://dx.doi.org/10.3390/antibiotics12030506 Text en © Crown copyright (2023), Dstl. This material is licensed under the terms of the Open Government Licence except where otherwise stated. To view this licence, visit http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk
spellingShingle Perspective
Nelson, Michelle
Barnes, Kay B.
Davies, Carwyn H.
Cote, Christopher K.
Meinig, J. Matthew
Biryukov, Sergei S.
Dyer, David N.
Frick, Ondraya
Heine, Henry
Pfefferle, Denise A.
Horstman-Smith, Amanda
Barbaras, Julie
Harding, Sarah V.
The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized Burkholderia pseudomallei
title The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized Burkholderia pseudomallei
title_full The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized Burkholderia pseudomallei
title_fullStr The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized Burkholderia pseudomallei
title_full_unstemmed The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized Burkholderia pseudomallei
title_short The BALB/c Mouse Model for the Evaluation of Therapies to Treat Infections with Aerosolized Burkholderia pseudomallei
title_sort balb/c mouse model for the evaluation of therapies to treat infections with aerosolized burkholderia pseudomallei
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044689/
https://www.ncbi.nlm.nih.gov/pubmed/36978372
http://dx.doi.org/10.3390/antibiotics12030506
work_keys_str_mv AT nelsonmichelle thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT barneskayb thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT daviescarwynh thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT cotechristopherk thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT meinigjmatthew thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT biryukovsergeis thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT dyerdavidn thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT frickondraya thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT heinehenry thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT pfefferledenisea thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT horstmansmithamanda thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT barbarasjulie thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT hardingsarahv thebalbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT nelsonmichelle balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT barneskayb balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT daviescarwynh balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT cotechristopherk balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT meinigjmatthew balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT biryukovsergeis balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT dyerdavidn balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT frickondraya balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT heinehenry balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT pfefferledenisea balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT horstmansmithamanda balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT barbarasjulie balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei
AT hardingsarahv balbcmousemodelfortheevaluationoftherapiestotreatinfectionswithaerosolizedburkholderiapseudomallei

Ejemplares similares