24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer’s Disease

Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved in Alzheimer’s disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degeneration, 24-hydroxycholesterol (24-OHC) has recently been...

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Detalles Bibliográficos
Autores principales: Testa, Gabriella, Giannelli, Serena, Sottero, Barbara, Staurenghi, Erica, Giaccone, Giorgio, Caroppo, Paola, Gamba, Paola, Leonarduzzi, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044740/
https://www.ncbi.nlm.nih.gov/pubmed/36978879
http://dx.doi.org/10.3390/antiox12030631

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