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Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites
A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing t...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044768/ https://www.ncbi.nlm.nih.gov/pubmed/36978462 http://dx.doi.org/10.3390/antibiotics12030596 |
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author | Wu, Jing Ohura, Takeru Ogura, Ryuhei Wang, Junhong Choi, Jae-Hoon Kobori, Hajime D’Alessandro-Gabazza, Corina N. Toda, Masaaki Yasuma, Taro Gabazza, Esteban C. Takikawa, Yuichi Hirai, Hirofumi Kawagishi, Hirokazu |
author_facet | Wu, Jing Ohura, Takeru Ogura, Ryuhei Wang, Junhong Choi, Jae-Hoon Kobori, Hajime D’Alessandro-Gabazza, Corina N. Toda, Masaaki Yasuma, Taro Gabazza, Esteban C. Takikawa, Yuichi Hirai, Hirofumi Kawagishi, Hirokazu |
author_sort | Wu, Jing |
collection | PubMed |
description | A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of 1 was determined to be R. This is the first time that compounds 2–4 were isolated from a mushroom-forming fungus. Compound 2 showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria Peptobacterium carotovorum, Clavibacter michiganensis and Burkholderia glumae, compounds 2 and 3 inhibited the growth of P. carotovorum and C. michiganensis. In the bioassay to examine plant growth regulatory activity, compounds 1–4 showed a significant regulatory activity on lettuce growth. |
format | Online Article Text |
id | pubmed-10044768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100447682023-03-29 Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites Wu, Jing Ohura, Takeru Ogura, Ryuhei Wang, Junhong Choi, Jae-Hoon Kobori, Hajime D’Alessandro-Gabazza, Corina N. Toda, Masaaki Yasuma, Taro Gabazza, Esteban C. Takikawa, Yuichi Hirai, Hirofumi Kawagishi, Hirokazu Antibiotics (Basel) Article A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of 1 was determined to be R. This is the first time that compounds 2–4 were isolated from a mushroom-forming fungus. Compound 2 showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria Peptobacterium carotovorum, Clavibacter michiganensis and Burkholderia glumae, compounds 2 and 3 inhibited the growth of P. carotovorum and C. michiganensis. In the bioassay to examine plant growth regulatory activity, compounds 1–4 showed a significant regulatory activity on lettuce growth. MDPI 2023-03-16 /pmc/articles/PMC10044768/ /pubmed/36978462 http://dx.doi.org/10.3390/antibiotics12030596 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wu, Jing Ohura, Takeru Ogura, Ryuhei Wang, Junhong Choi, Jae-Hoon Kobori, Hajime D’Alessandro-Gabazza, Corina N. Toda, Masaaki Yasuma, Taro Gabazza, Esteban C. Takikawa, Yuichi Hirai, Hirofumi Kawagishi, Hirokazu Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites |
title | Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites |
title_full | Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites |
title_fullStr | Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites |
title_full_unstemmed | Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites |
title_short | Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites |
title_sort | bioactive compounds from the mushroom-forming fungus chlorophyllum molybdites |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044768/ https://www.ncbi.nlm.nih.gov/pubmed/36978462 http://dx.doi.org/10.3390/antibiotics12030596 |
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