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Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites

A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing t...

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Autores principales: Wu, Jing, Ohura, Takeru, Ogura, Ryuhei, Wang, Junhong, Choi, Jae-Hoon, Kobori, Hajime, D’Alessandro-Gabazza, Corina N., Toda, Masaaki, Yasuma, Taro, Gabazza, Esteban C., Takikawa, Yuichi, Hirai, Hirofumi, Kawagishi, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044768/
https://www.ncbi.nlm.nih.gov/pubmed/36978462
http://dx.doi.org/10.3390/antibiotics12030596
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author Wu, Jing
Ohura, Takeru
Ogura, Ryuhei
Wang, Junhong
Choi, Jae-Hoon
Kobori, Hajime
D’Alessandro-Gabazza, Corina N.
Toda, Masaaki
Yasuma, Taro
Gabazza, Esteban C.
Takikawa, Yuichi
Hirai, Hirofumi
Kawagishi, Hirokazu
author_facet Wu, Jing
Ohura, Takeru
Ogura, Ryuhei
Wang, Junhong
Choi, Jae-Hoon
Kobori, Hajime
D’Alessandro-Gabazza, Corina N.
Toda, Masaaki
Yasuma, Taro
Gabazza, Esteban C.
Takikawa, Yuichi
Hirai, Hirofumi
Kawagishi, Hirokazu
author_sort Wu, Jing
collection PubMed
description A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of 1 was determined to be R. This is the first time that compounds 2–4 were isolated from a mushroom-forming fungus. Compound 2 showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria Peptobacterium carotovorum, Clavibacter michiganensis and Burkholderia glumae, compounds 2 and 3 inhibited the growth of P. carotovorum and C. michiganensis. In the bioassay to examine plant growth regulatory activity, compounds 1–4 showed a significant regulatory activity on lettuce growth.
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spelling pubmed-100447682023-03-29 Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites Wu, Jing Ohura, Takeru Ogura, Ryuhei Wang, Junhong Choi, Jae-Hoon Kobori, Hajime D’Alessandro-Gabazza, Corina N. Toda, Masaaki Yasuma, Taro Gabazza, Esteban C. Takikawa, Yuichi Hirai, Hirofumi Kawagishi, Hirokazu Antibiotics (Basel) Article A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4–6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of 1 was determined to be R. This is the first time that compounds 2–4 were isolated from a mushroom-forming fungus. Compound 2 showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria Peptobacterium carotovorum, Clavibacter michiganensis and Burkholderia glumae, compounds 2 and 3 inhibited the growth of P. carotovorum and C. michiganensis. In the bioassay to examine plant growth regulatory activity, compounds 1–4 showed a significant regulatory activity on lettuce growth. MDPI 2023-03-16 /pmc/articles/PMC10044768/ /pubmed/36978462 http://dx.doi.org/10.3390/antibiotics12030596 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Jing
Ohura, Takeru
Ogura, Ryuhei
Wang, Junhong
Choi, Jae-Hoon
Kobori, Hajime
D’Alessandro-Gabazza, Corina N.
Toda, Masaaki
Yasuma, Taro
Gabazza, Esteban C.
Takikawa, Yuichi
Hirai, Hirofumi
Kawagishi, Hirokazu
Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites
title Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites
title_full Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites
title_fullStr Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites
title_full_unstemmed Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites
title_short Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites
title_sort bioactive compounds from the mushroom-forming fungus chlorophyllum molybdites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044768/
https://www.ncbi.nlm.nih.gov/pubmed/36978462
http://dx.doi.org/10.3390/antibiotics12030596
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