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Recoding of Nonsense Mutation as a Pharmacological Strategy
Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. The PTC results in the production of a potentially harmful shortened polypeptide and activation of a nonsense-mediated decay (NMD) pathway. The NM...
Autores principales: | Temaj, Gazmend, Telkoparan-Akillilar, Pelin, Nuhii, Nexhibe, Chichiarelli, Silvia, Saha, Sarmistha, Saso, Luciano |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044939/ https://www.ncbi.nlm.nih.gov/pubmed/36979640 http://dx.doi.org/10.3390/biomedicines11030659 |
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