Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery

Postoperative cognitive dysfunction (POCD) is a severe neurological complication after anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy due to its unclear pathogenesis. Caffeic acid phenethyl ester (CAPE), which is obtained from honeybee propolis and medic...

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Detalles Bibliográficos
Autores principales: Wang, Yue, Cai, Ziwen, Zhan, Gaofeng, Li, Xing, Li, Shan, Wang, Xuan, Li, Shiyong, Luo, Ailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045012/
https://www.ncbi.nlm.nih.gov/pubmed/36978961
http://dx.doi.org/10.3390/antiox12030714

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