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Modelling the Complexity of Human Skin In Vitro

The skin serves as an important barrier protecting the body from physical, chemical and pathogenic hazards as well as regulating the bi-directional transport of water, ions and nutrients. In order to improve the knowledge on skin structure and function as well as on skin diseases, animal experiments...

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Detalles Bibliográficos
Autores principales: Hofmann, Elisabeth, Schwarz, Anna, Fink, Julia, Kamolz, Lars-Peter, Kotzbeck, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045055/
https://www.ncbi.nlm.nih.gov/pubmed/36979772
http://dx.doi.org/10.3390/biomedicines11030794
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author Hofmann, Elisabeth
Schwarz, Anna
Fink, Julia
Kamolz, Lars-Peter
Kotzbeck, Petra
author_facet Hofmann, Elisabeth
Schwarz, Anna
Fink, Julia
Kamolz, Lars-Peter
Kotzbeck, Petra
author_sort Hofmann, Elisabeth
collection PubMed
description The skin serves as an important barrier protecting the body from physical, chemical and pathogenic hazards as well as regulating the bi-directional transport of water, ions and nutrients. In order to improve the knowledge on skin structure and function as well as on skin diseases, animal experiments are often employed, but anatomical as well as physiological interspecies differences may result in poor translatability of animal-based data to the clinical situation. In vitro models, such as human reconstructed epidermis or full skin equivalents, are valuable alternatives to animal experiments. Enormous advances have been achieved in establishing skin models of increasing complexity in the past. In this review, human skin structures are described as well as the fast evolving technologies developed to reconstruct the complexity of human skin structures in vitro.
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spelling pubmed-100450552023-03-29 Modelling the Complexity of Human Skin In Vitro Hofmann, Elisabeth Schwarz, Anna Fink, Julia Kamolz, Lars-Peter Kotzbeck, Petra Biomedicines Review The skin serves as an important barrier protecting the body from physical, chemical and pathogenic hazards as well as regulating the bi-directional transport of water, ions and nutrients. In order to improve the knowledge on skin structure and function as well as on skin diseases, animal experiments are often employed, but anatomical as well as physiological interspecies differences may result in poor translatability of animal-based data to the clinical situation. In vitro models, such as human reconstructed epidermis or full skin equivalents, are valuable alternatives to animal experiments. Enormous advances have been achieved in establishing skin models of increasing complexity in the past. In this review, human skin structures are described as well as the fast evolving technologies developed to reconstruct the complexity of human skin structures in vitro. MDPI 2023-03-06 /pmc/articles/PMC10045055/ /pubmed/36979772 http://dx.doi.org/10.3390/biomedicines11030794 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hofmann, Elisabeth
Schwarz, Anna
Fink, Julia
Kamolz, Lars-Peter
Kotzbeck, Petra
Modelling the Complexity of Human Skin In Vitro
title Modelling the Complexity of Human Skin In Vitro
title_full Modelling the Complexity of Human Skin In Vitro
title_fullStr Modelling the Complexity of Human Skin In Vitro
title_full_unstemmed Modelling the Complexity of Human Skin In Vitro
title_short Modelling the Complexity of Human Skin In Vitro
title_sort modelling the complexity of human skin in vitro
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045055/
https://www.ncbi.nlm.nih.gov/pubmed/36979772
http://dx.doi.org/10.3390/biomedicines11030794
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