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A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types
Potassium channels are often highly expressed in cancer cells with respect to healthy ones, as they provide proliferative advantages through modulating membrane potential, calcium homeostasis, and various signaling pathways. Among potassium channels, Shaker type voltage-gated Kv channels are emergin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045123/ https://www.ncbi.nlm.nih.gov/pubmed/36978819 http://dx.doi.org/10.3390/antiox12030573 |
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author | Angi, Beatrice Muccioli, Silvia Szabò, Ildikò Leanza, Luigi |
author_facet | Angi, Beatrice Muccioli, Silvia Szabò, Ildikò Leanza, Luigi |
author_sort | Angi, Beatrice |
collection | PubMed |
description | Potassium channels are often highly expressed in cancer cells with respect to healthy ones, as they provide proliferative advantages through modulating membrane potential, calcium homeostasis, and various signaling pathways. Among potassium channels, Shaker type voltage-gated Kv channels are emerging as promising pharmacological targets in oncology. Here, we queried publicly available cancer patient databases to highlight if a correlation exists between Kv channel expression and survival rate in five different cancer types. By multiple gene comparison analysis, we found a predominant expression of KCNA2, KCNA3, and KCNA5 with respect to the other KCNA genes in skin cutaneous melanoma (SKCM), uterine corpus endometrial carcinoma (UCEC), stomach adenocarcinoma (STAD), lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC). This analysis highlighted a prognostic role of KCNA3 and KCNA5 in SKCM, LUAD, LUSC, and STAD, respectively. Interestingly, KCNA3 was associated with a positive prognosis in SKCM and LUAD but not in LUSC. Results obtained by the analysis of KCNA3-related differentially expressed genes (DEGs); tumor immune cell infiltration highlighted differences that may account for such differential prognosis. A meta-analysis study was conducted to investigate the role of KCNA channels in cancer using cancer patients’ datasets. Our study underlines a promising correlation between Kv channel expression in tumor cells, in infiltrating immune cells, and survival rate. |
format | Online Article Text |
id | pubmed-10045123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100451232023-03-29 A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types Angi, Beatrice Muccioli, Silvia Szabò, Ildikò Leanza, Luigi Antioxidants (Basel) Article Potassium channels are often highly expressed in cancer cells with respect to healthy ones, as they provide proliferative advantages through modulating membrane potential, calcium homeostasis, and various signaling pathways. Among potassium channels, Shaker type voltage-gated Kv channels are emerging as promising pharmacological targets in oncology. Here, we queried publicly available cancer patient databases to highlight if a correlation exists between Kv channel expression and survival rate in five different cancer types. By multiple gene comparison analysis, we found a predominant expression of KCNA2, KCNA3, and KCNA5 with respect to the other KCNA genes in skin cutaneous melanoma (SKCM), uterine corpus endometrial carcinoma (UCEC), stomach adenocarcinoma (STAD), lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC). This analysis highlighted a prognostic role of KCNA3 and KCNA5 in SKCM, LUAD, LUSC, and STAD, respectively. Interestingly, KCNA3 was associated with a positive prognosis in SKCM and LUAD but not in LUSC. Results obtained by the analysis of KCNA3-related differentially expressed genes (DEGs); tumor immune cell infiltration highlighted differences that may account for such differential prognosis. A meta-analysis study was conducted to investigate the role of KCNA channels in cancer using cancer patients’ datasets. Our study underlines a promising correlation between Kv channel expression in tumor cells, in infiltrating immune cells, and survival rate. MDPI 2023-02-24 /pmc/articles/PMC10045123/ /pubmed/36978819 http://dx.doi.org/10.3390/antiox12030573 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Angi, Beatrice Muccioli, Silvia Szabò, Ildikò Leanza, Luigi A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types |
title | A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types |
title_full | A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types |
title_fullStr | A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types |
title_full_unstemmed | A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types |
title_short | A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types |
title_sort | meta-analysis study to infer voltage-gated k(+) channels prognostic value in different cancer types |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045123/ https://www.ncbi.nlm.nih.gov/pubmed/36978819 http://dx.doi.org/10.3390/antiox12030573 |
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