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A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types

Potassium channels are often highly expressed in cancer cells with respect to healthy ones, as they provide proliferative advantages through modulating membrane potential, calcium homeostasis, and various signaling pathways. Among potassium channels, Shaker type voltage-gated Kv channels are emergin...

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Autores principales: Angi, Beatrice, Muccioli, Silvia, Szabò, Ildikò, Leanza, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045123/
https://www.ncbi.nlm.nih.gov/pubmed/36978819
http://dx.doi.org/10.3390/antiox12030573
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author Angi, Beatrice
Muccioli, Silvia
Szabò, Ildikò
Leanza, Luigi
author_facet Angi, Beatrice
Muccioli, Silvia
Szabò, Ildikò
Leanza, Luigi
author_sort Angi, Beatrice
collection PubMed
description Potassium channels are often highly expressed in cancer cells with respect to healthy ones, as they provide proliferative advantages through modulating membrane potential, calcium homeostasis, and various signaling pathways. Among potassium channels, Shaker type voltage-gated Kv channels are emerging as promising pharmacological targets in oncology. Here, we queried publicly available cancer patient databases to highlight if a correlation exists between Kv channel expression and survival rate in five different cancer types. By multiple gene comparison analysis, we found a predominant expression of KCNA2, KCNA3, and KCNA5 with respect to the other KCNA genes in skin cutaneous melanoma (SKCM), uterine corpus endometrial carcinoma (UCEC), stomach adenocarcinoma (STAD), lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC). This analysis highlighted a prognostic role of KCNA3 and KCNA5 in SKCM, LUAD, LUSC, and STAD, respectively. Interestingly, KCNA3 was associated with a positive prognosis in SKCM and LUAD but not in LUSC. Results obtained by the analysis of KCNA3-related differentially expressed genes (DEGs); tumor immune cell infiltration highlighted differences that may account for such differential prognosis. A meta-analysis study was conducted to investigate the role of KCNA channels in cancer using cancer patients’ datasets. Our study underlines a promising correlation between Kv channel expression in tumor cells, in infiltrating immune cells, and survival rate.
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spelling pubmed-100451232023-03-29 A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types Angi, Beatrice Muccioli, Silvia Szabò, Ildikò Leanza, Luigi Antioxidants (Basel) Article Potassium channels are often highly expressed in cancer cells with respect to healthy ones, as they provide proliferative advantages through modulating membrane potential, calcium homeostasis, and various signaling pathways. Among potassium channels, Shaker type voltage-gated Kv channels are emerging as promising pharmacological targets in oncology. Here, we queried publicly available cancer patient databases to highlight if a correlation exists between Kv channel expression and survival rate in five different cancer types. By multiple gene comparison analysis, we found a predominant expression of KCNA2, KCNA3, and KCNA5 with respect to the other KCNA genes in skin cutaneous melanoma (SKCM), uterine corpus endometrial carcinoma (UCEC), stomach adenocarcinoma (STAD), lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC). This analysis highlighted a prognostic role of KCNA3 and KCNA5 in SKCM, LUAD, LUSC, and STAD, respectively. Interestingly, KCNA3 was associated with a positive prognosis in SKCM and LUAD but not in LUSC. Results obtained by the analysis of KCNA3-related differentially expressed genes (DEGs); tumor immune cell infiltration highlighted differences that may account for such differential prognosis. A meta-analysis study was conducted to investigate the role of KCNA channels in cancer using cancer patients’ datasets. Our study underlines a promising correlation between Kv channel expression in tumor cells, in infiltrating immune cells, and survival rate. MDPI 2023-02-24 /pmc/articles/PMC10045123/ /pubmed/36978819 http://dx.doi.org/10.3390/antiox12030573 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Angi, Beatrice
Muccioli, Silvia
Szabò, Ildikò
Leanza, Luigi
A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types
title A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types
title_full A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types
title_fullStr A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types
title_full_unstemmed A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types
title_short A Meta-Analysis Study to Infer Voltage-Gated K(+) Channels Prognostic Value in Different Cancer Types
title_sort meta-analysis study to infer voltage-gated k(+) channels prognostic value in different cancer types
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045123/
https://www.ncbi.nlm.nih.gov/pubmed/36978819
http://dx.doi.org/10.3390/antiox12030573
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