Insulin-like Growth Factor-1 Prevents Hypoxia/Reoxygenation-Induced White Matter Injury in Sickle Cell Mice

Occlusion of cerebral blood vessels causes acute cerebral hypoxia—an important trigger of ischemic white matter injury and stroke in sickle cell disease (SCD). While chronic hypoxia triggers compensatory neuroprotection via insulin-like growth factor-1 (IGF-1) and hypoxia inducible factor-1α (HIF-1α...

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Detalles Bibliográficos
Autores principales: Hazra, Rimi, Hubert, Holland, Little-Ihrig, Lynda, Ghosh, Samit, Ofori-Acquah, Solomon, Hu, Xiaoming, Novelli, Enrico M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045140/
https://www.ncbi.nlm.nih.gov/pubmed/36979670
http://dx.doi.org/10.3390/biomedicines11030692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045140/
https://www.ncbi.nlm.nih.gov/pubmed/36979670
http://dx.doi.org/10.3390/biomedicines11030692

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