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The Role of the Ectopeptidase APN/CD13 in Cancer
APN/CD13 is expressed in a variety of cells/tissues and is therefore associated with diverse physiological functions, including proliferation, differentiation, migration, angiogenesis, invasion, metastasis, vasoconstriction, and the regulation of normal and impaired immune function. Increased expres...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045183/ https://www.ncbi.nlm.nih.gov/pubmed/36979703 http://dx.doi.org/10.3390/biomedicines11030724 |
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author | Lendeckel, Uwe Karimi, Farzaneh Al Abdulla, Ruba Wolke, Carmen |
author_facet | Lendeckel, Uwe Karimi, Farzaneh Al Abdulla, Ruba Wolke, Carmen |
author_sort | Lendeckel, Uwe |
collection | PubMed |
description | APN/CD13 is expressed in a variety of cells/tissues and is therefore associated with diverse physiological functions, including proliferation, differentiation, migration, angiogenesis, invasion, metastasis, vasoconstriction, and the regulation of normal and impaired immune function. Increased expression or activity of APN/CD13 has been described for various tumors, such that APN/CD13 is in most cases associated with reduced disease-free and overall survival. The mechanisms that mediate these cellular effects of APN/CD13 have been largely determined and are described here. APN/CD13-regulated signaling pathways include integrin recycling, the regulation of small GTPase activities, cell–ECM interactions, and Erk1/2, PI3K, and Wnt signaling. APN/CD13 is a neo-angiogenesis marker that is not found on normal endothelia, but it is found on neo-angiogenetically active endothelia. Therefore, APN/CD13 represents a specific receptor for so-called “tumor-homing peptides” (NRG peptides). Peptides containing the NRG motif show high-affinity binding to APN/CD13. APN/CD13 thus represents a versatile target for the inhibition of tumor-induced angiogenesis through the tumor-selective administration of, e.g., cytotoxic substances. Furthermore, it enables the molecular imaging of tumor masses and the assessment of (neo)angiogenesis in animal models and in patients. Pharmacological inhibitors of APN/CD13 have been proven to reduce tumor growth and tumor progression in various APN/CD13-positive tumors. |
format | Online Article Text |
id | pubmed-10045183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100451832023-03-29 The Role of the Ectopeptidase APN/CD13 in Cancer Lendeckel, Uwe Karimi, Farzaneh Al Abdulla, Ruba Wolke, Carmen Biomedicines Review APN/CD13 is expressed in a variety of cells/tissues and is therefore associated with diverse physiological functions, including proliferation, differentiation, migration, angiogenesis, invasion, metastasis, vasoconstriction, and the regulation of normal and impaired immune function. Increased expression or activity of APN/CD13 has been described for various tumors, such that APN/CD13 is in most cases associated with reduced disease-free and overall survival. The mechanisms that mediate these cellular effects of APN/CD13 have been largely determined and are described here. APN/CD13-regulated signaling pathways include integrin recycling, the regulation of small GTPase activities, cell–ECM interactions, and Erk1/2, PI3K, and Wnt signaling. APN/CD13 is a neo-angiogenesis marker that is not found on normal endothelia, but it is found on neo-angiogenetically active endothelia. Therefore, APN/CD13 represents a specific receptor for so-called “tumor-homing peptides” (NRG peptides). Peptides containing the NRG motif show high-affinity binding to APN/CD13. APN/CD13 thus represents a versatile target for the inhibition of tumor-induced angiogenesis through the tumor-selective administration of, e.g., cytotoxic substances. Furthermore, it enables the molecular imaging of tumor masses and the assessment of (neo)angiogenesis in animal models and in patients. Pharmacological inhibitors of APN/CD13 have been proven to reduce tumor growth and tumor progression in various APN/CD13-positive tumors. MDPI 2023-02-28 /pmc/articles/PMC10045183/ /pubmed/36979703 http://dx.doi.org/10.3390/biomedicines11030724 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lendeckel, Uwe Karimi, Farzaneh Al Abdulla, Ruba Wolke, Carmen The Role of the Ectopeptidase APN/CD13 in Cancer |
title | The Role of the Ectopeptidase APN/CD13 in Cancer |
title_full | The Role of the Ectopeptidase APN/CD13 in Cancer |
title_fullStr | The Role of the Ectopeptidase APN/CD13 in Cancer |
title_full_unstemmed | The Role of the Ectopeptidase APN/CD13 in Cancer |
title_short | The Role of the Ectopeptidase APN/CD13 in Cancer |
title_sort | role of the ectopeptidase apn/cd13 in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045183/ https://www.ncbi.nlm.nih.gov/pubmed/36979703 http://dx.doi.org/10.3390/biomedicines11030724 |
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