Cargando…

The Role of the Ectopeptidase APN/CD13 in Cancer

APN/CD13 is expressed in a variety of cells/tissues and is therefore associated with diverse physiological functions, including proliferation, differentiation, migration, angiogenesis, invasion, metastasis, vasoconstriction, and the regulation of normal and impaired immune function. Increased expres...

Descripción completa

Detalles Bibliográficos
Autores principales: Lendeckel, Uwe, Karimi, Farzaneh, Al Abdulla, Ruba, Wolke, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045183/
https://www.ncbi.nlm.nih.gov/pubmed/36979703
http://dx.doi.org/10.3390/biomedicines11030724
_version_ 1784913539147759616
author Lendeckel, Uwe
Karimi, Farzaneh
Al Abdulla, Ruba
Wolke, Carmen
author_facet Lendeckel, Uwe
Karimi, Farzaneh
Al Abdulla, Ruba
Wolke, Carmen
author_sort Lendeckel, Uwe
collection PubMed
description APN/CD13 is expressed in a variety of cells/tissues and is therefore associated with diverse physiological functions, including proliferation, differentiation, migration, angiogenesis, invasion, metastasis, vasoconstriction, and the regulation of normal and impaired immune function. Increased expression or activity of APN/CD13 has been described for various tumors, such that APN/CD13 is in most cases associated with reduced disease-free and overall survival. The mechanisms that mediate these cellular effects of APN/CD13 have been largely determined and are described here. APN/CD13-regulated signaling pathways include integrin recycling, the regulation of small GTPase activities, cell–ECM interactions, and Erk1/2, PI3K, and Wnt signaling. APN/CD13 is a neo-angiogenesis marker that is not found on normal endothelia, but it is found on neo-angiogenetically active endothelia. Therefore, APN/CD13 represents a specific receptor for so-called “tumor-homing peptides” (NRG peptides). Peptides containing the NRG motif show high-affinity binding to APN/CD13. APN/CD13 thus represents a versatile target for the inhibition of tumor-induced angiogenesis through the tumor-selective administration of, e.g., cytotoxic substances. Furthermore, it enables the molecular imaging of tumor masses and the assessment of (neo)angiogenesis in animal models and in patients. Pharmacological inhibitors of APN/CD13 have been proven to reduce tumor growth and tumor progression in various APN/CD13-positive tumors.
format Online
Article
Text
id pubmed-10045183
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100451832023-03-29 The Role of the Ectopeptidase APN/CD13 in Cancer Lendeckel, Uwe Karimi, Farzaneh Al Abdulla, Ruba Wolke, Carmen Biomedicines Review APN/CD13 is expressed in a variety of cells/tissues and is therefore associated with diverse physiological functions, including proliferation, differentiation, migration, angiogenesis, invasion, metastasis, vasoconstriction, and the regulation of normal and impaired immune function. Increased expression or activity of APN/CD13 has been described for various tumors, such that APN/CD13 is in most cases associated with reduced disease-free and overall survival. The mechanisms that mediate these cellular effects of APN/CD13 have been largely determined and are described here. APN/CD13-regulated signaling pathways include integrin recycling, the regulation of small GTPase activities, cell–ECM interactions, and Erk1/2, PI3K, and Wnt signaling. APN/CD13 is a neo-angiogenesis marker that is not found on normal endothelia, but it is found on neo-angiogenetically active endothelia. Therefore, APN/CD13 represents a specific receptor for so-called “tumor-homing peptides” (NRG peptides). Peptides containing the NRG motif show high-affinity binding to APN/CD13. APN/CD13 thus represents a versatile target for the inhibition of tumor-induced angiogenesis through the tumor-selective administration of, e.g., cytotoxic substances. Furthermore, it enables the molecular imaging of tumor masses and the assessment of (neo)angiogenesis in animal models and in patients. Pharmacological inhibitors of APN/CD13 have been proven to reduce tumor growth and tumor progression in various APN/CD13-positive tumors. MDPI 2023-02-28 /pmc/articles/PMC10045183/ /pubmed/36979703 http://dx.doi.org/10.3390/biomedicines11030724 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lendeckel, Uwe
Karimi, Farzaneh
Al Abdulla, Ruba
Wolke, Carmen
The Role of the Ectopeptidase APN/CD13 in Cancer
title The Role of the Ectopeptidase APN/CD13 in Cancer
title_full The Role of the Ectopeptidase APN/CD13 in Cancer
title_fullStr The Role of the Ectopeptidase APN/CD13 in Cancer
title_full_unstemmed The Role of the Ectopeptidase APN/CD13 in Cancer
title_short The Role of the Ectopeptidase APN/CD13 in Cancer
title_sort role of the ectopeptidase apn/cd13 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045183/
https://www.ncbi.nlm.nih.gov/pubmed/36979703
http://dx.doi.org/10.3390/biomedicines11030724
work_keys_str_mv AT lendeckeluwe theroleoftheectopeptidaseapncd13incancer
AT karimifarzaneh theroleoftheectopeptidaseapncd13incancer
AT alabdullaruba theroleoftheectopeptidaseapncd13incancer
AT wolkecarmen theroleoftheectopeptidaseapncd13incancer
AT lendeckeluwe roleoftheectopeptidaseapncd13incancer
AT karimifarzaneh roleoftheectopeptidaseapncd13incancer
AT alabdullaruba roleoftheectopeptidaseapncd13incancer
AT wolkecarmen roleoftheectopeptidaseapncd13incancer