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Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study

Type I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the path...

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Autores principales: Sheikh-Ahmad, Mohammad, Saiegh, Leonard, Shalata, Anan, Bejar, Jacob, Kreizman-Shefer, Hila, Sirhan, Majd F., Matter, Ibrahim, Swaid, Forat, Laniado, Monica, Mubariki, Nama, Rainis, Tova, Rosenblatt, Ilana, Yovanovich, Ekaterina, Agbarya, Abed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045191/
https://www.ncbi.nlm.nih.gov/pubmed/36979807
http://dx.doi.org/10.3390/biomedicines11030828
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author Sheikh-Ahmad, Mohammad
Saiegh, Leonard
Shalata, Anan
Bejar, Jacob
Kreizman-Shefer, Hila
Sirhan, Majd F.
Matter, Ibrahim
Swaid, Forat
Laniado, Monica
Mubariki, Nama
Rainis, Tova
Rosenblatt, Ilana
Yovanovich, Ekaterina
Agbarya, Abed
author_facet Sheikh-Ahmad, Mohammad
Saiegh, Leonard
Shalata, Anan
Bejar, Jacob
Kreizman-Shefer, Hila
Sirhan, Majd F.
Matter, Ibrahim
Swaid, Forat
Laniado, Monica
Mubariki, Nama
Rainis, Tova
Rosenblatt, Ilana
Yovanovich, Ekaterina
Agbarya, Abed
author_sort Sheikh-Ahmad, Mohammad
collection PubMed
description Type I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the pathological and biochemical data of patients with type I gNENs treated at Bnai Zion Medical Center between 2006 and 2022 were analyzed retrospectively. Twenty-seven type I gNENs were evaluated. The follow-up period was 41 months (range: 11–288 months). Recurrence of the tumor occurred in 13/27 (48%) patients after 35 months (median (M), interquartile range (IQR): 21–67.5). Serum gastrin levels were significantly higher in patients with recurrent disease versus patients with non-recurrent disease (788 vs. 394 ng/L; p = 0.047), while the Ki-67 index was significantly lower in patients with recurrent disease versus patients with non-recurrent disease (1% vs. 3.5%; p = 0.035). Tumor size, mitotic count, and serum chromogranin A levels did not correlate with recurrence. The present study emphasizes the role of gastrin in the pathogenesis of gNEN recurrence and highlights the debate regarding the ability of the Ki-67 index to predict the clinical course of this disease.
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spelling pubmed-100451912023-03-29 Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study Sheikh-Ahmad, Mohammad Saiegh, Leonard Shalata, Anan Bejar, Jacob Kreizman-Shefer, Hila Sirhan, Majd F. Matter, Ibrahim Swaid, Forat Laniado, Monica Mubariki, Nama Rainis, Tova Rosenblatt, Ilana Yovanovich, Ekaterina Agbarya, Abed Biomedicines Article Type I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the pathological and biochemical data of patients with type I gNENs treated at Bnai Zion Medical Center between 2006 and 2022 were analyzed retrospectively. Twenty-seven type I gNENs were evaluated. The follow-up period was 41 months (range: 11–288 months). Recurrence of the tumor occurred in 13/27 (48%) patients after 35 months (median (M), interquartile range (IQR): 21–67.5). Serum gastrin levels were significantly higher in patients with recurrent disease versus patients with non-recurrent disease (788 vs. 394 ng/L; p = 0.047), while the Ki-67 index was significantly lower in patients with recurrent disease versus patients with non-recurrent disease (1% vs. 3.5%; p = 0.035). Tumor size, mitotic count, and serum chromogranin A levels did not correlate with recurrence. The present study emphasizes the role of gastrin in the pathogenesis of gNEN recurrence and highlights the debate regarding the ability of the Ki-67 index to predict the clinical course of this disease. MDPI 2023-03-09 /pmc/articles/PMC10045191/ /pubmed/36979807 http://dx.doi.org/10.3390/biomedicines11030828 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sheikh-Ahmad, Mohammad
Saiegh, Leonard
Shalata, Anan
Bejar, Jacob
Kreizman-Shefer, Hila
Sirhan, Majd F.
Matter, Ibrahim
Swaid, Forat
Laniado, Monica
Mubariki, Nama
Rainis, Tova
Rosenblatt, Ilana
Yovanovich, Ekaterina
Agbarya, Abed
Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study
title Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study
title_full Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study
title_fullStr Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study
title_full_unstemmed Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study
title_short Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study
title_sort factors predicting type i gastric neuroendocrine neoplasia recurrence: a single-center study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045191/
https://www.ncbi.nlm.nih.gov/pubmed/36979807
http://dx.doi.org/10.3390/biomedicines11030828
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