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Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives
4-Aminodiphenylamino derivatives were investigated for their antioxidant and hydrophobicity character, together with other biological measurements, such as antimicrobial and antibiofilm activity. Among these nine compounds used, we obtained novel derivatives via reaction of the starting material wit...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045258/ https://www.ncbi.nlm.nih.gov/pubmed/36978960 http://dx.doi.org/10.3390/antiox12030713 |
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author | Bujor, Alexandru Hanganu, Anamaria Tecuceanu, Victorita Madalan, Augustin M. Tudose, Madalina Marutescu, Luminita Popa, Marcela Chifiriuc, Carmen Mariana Zarafu, Irina Ionita, Petre |
author_facet | Bujor, Alexandru Hanganu, Anamaria Tecuceanu, Victorita Madalan, Augustin M. Tudose, Madalina Marutescu, Luminita Popa, Marcela Chifiriuc, Carmen Mariana Zarafu, Irina Ionita, Petre |
author_sort | Bujor, Alexandru |
collection | PubMed |
description | 4-Aminodiphenylamino derivatives were investigated for their antioxidant and hydrophobicity character, together with other biological measurements, such as antimicrobial and antibiofilm activity. Among these nine compounds used, we obtained novel derivatives via reaction of the starting material with NBD-chloride. Therefore, we performed a full structural analysis for these compounds, i.e., elemental analysis, IR, UV-Vis, (1)H- and (13)C-NMR, ESI-MS, X-ray diffraction on single crystal, etc. The hydrophobicity of all the compounds was measured either experimentally using the RP-TLC technique, or via calculation using the fragments method. The other structural characteristics were analyzed, and a correlation between the experimental and computed properties was found. Moreover, the results of the biological evaluation showed that some of the synthesized compounds have antimicrobial and antibiofilm activity. |
format | Online Article Text |
id | pubmed-10045258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100452582023-03-29 Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives Bujor, Alexandru Hanganu, Anamaria Tecuceanu, Victorita Madalan, Augustin M. Tudose, Madalina Marutescu, Luminita Popa, Marcela Chifiriuc, Carmen Mariana Zarafu, Irina Ionita, Petre Antioxidants (Basel) Article 4-Aminodiphenylamino derivatives were investigated for their antioxidant and hydrophobicity character, together with other biological measurements, such as antimicrobial and antibiofilm activity. Among these nine compounds used, we obtained novel derivatives via reaction of the starting material with NBD-chloride. Therefore, we performed a full structural analysis for these compounds, i.e., elemental analysis, IR, UV-Vis, (1)H- and (13)C-NMR, ESI-MS, X-ray diffraction on single crystal, etc. The hydrophobicity of all the compounds was measured either experimentally using the RP-TLC technique, or via calculation using the fragments method. The other structural characteristics were analyzed, and a correlation between the experimental and computed properties was found. Moreover, the results of the biological evaluation showed that some of the synthesized compounds have antimicrobial and antibiofilm activity. MDPI 2023-03-13 /pmc/articles/PMC10045258/ /pubmed/36978960 http://dx.doi.org/10.3390/antiox12030713 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bujor, Alexandru Hanganu, Anamaria Tecuceanu, Victorita Madalan, Augustin M. Tudose, Madalina Marutescu, Luminita Popa, Marcela Chifiriuc, Carmen Mariana Zarafu, Irina Ionita, Petre Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives |
title | Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives |
title_full | Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives |
title_fullStr | Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives |
title_full_unstemmed | Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives |
title_short | Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives |
title_sort | biological evaluation and structural analysis of some aminodiphenylamine derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045258/ https://www.ncbi.nlm.nih.gov/pubmed/36978960 http://dx.doi.org/10.3390/antiox12030713 |
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