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HDL-Based Therapy: Vascular Protection at All Stages

It is known that lipid metabolism disorders are involved in a wide range of pathologies. These pathologies include cardiovascular, metabolic, neurodegenerative diseases, and even cancer. All these diseases lead to serious health consequences, which makes it impossible to ignore them. Unfortunately,...

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Autores principales: Poznyak, Anastasia V., Sukhorukov, Vasily N., Eremin, Ilya I., Nadelyaeva, Irina I., Gutyrchik, Nikita A., Orekhov, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045384/
https://www.ncbi.nlm.nih.gov/pubmed/36979690
http://dx.doi.org/10.3390/biomedicines11030711
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author Poznyak, Anastasia V.
Sukhorukov, Vasily N.
Eremin, Ilya I.
Nadelyaeva, Irina I.
Gutyrchik, Nikita A.
Orekhov, Alexander N.
author_facet Poznyak, Anastasia V.
Sukhorukov, Vasily N.
Eremin, Ilya I.
Nadelyaeva, Irina I.
Gutyrchik, Nikita A.
Orekhov, Alexander N.
author_sort Poznyak, Anastasia V.
collection PubMed
description It is known that lipid metabolism disorders are involved in a wide range of pathologies. These pathologies include cardiovascular, metabolic, neurodegenerative diseases, and even cancer. All these diseases lead to serious health consequences, which makes it impossible to ignore them. Unfortunately, these diseases most often have a complex pathogenesis, which makes it difficult to study them and, in particular, diagnose and treat them. HDL is an important part of lipid metabolism, performing many functions under normal conditions. One of such functions is the maintaining of the reverse cholesterol transport. These functions are also implicated in pathology development. Thus, HDL contributes to vascular protection, which has been demonstrated in various conditions: Alzheimer’s disease, atherosclerosis, etc. Many studies have shown that serum levels of HDL cholesterol correlate negatively with CV risk. With these data, HDL-C is a promising therapeutic target. In this manuscript, we reviewed HDL-based therapeutic strategies that are currently being used or may be developed soon.
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spelling pubmed-100453842023-03-29 HDL-Based Therapy: Vascular Protection at All Stages Poznyak, Anastasia V. Sukhorukov, Vasily N. Eremin, Ilya I. Nadelyaeva, Irina I. Gutyrchik, Nikita A. Orekhov, Alexander N. Biomedicines Review It is known that lipid metabolism disorders are involved in a wide range of pathologies. These pathologies include cardiovascular, metabolic, neurodegenerative diseases, and even cancer. All these diseases lead to serious health consequences, which makes it impossible to ignore them. Unfortunately, these diseases most often have a complex pathogenesis, which makes it difficult to study them and, in particular, diagnose and treat them. HDL is an important part of lipid metabolism, performing many functions under normal conditions. One of such functions is the maintaining of the reverse cholesterol transport. These functions are also implicated in pathology development. Thus, HDL contributes to vascular protection, which has been demonstrated in various conditions: Alzheimer’s disease, atherosclerosis, etc. Many studies have shown that serum levels of HDL cholesterol correlate negatively with CV risk. With these data, HDL-C is a promising therapeutic target. In this manuscript, we reviewed HDL-based therapeutic strategies that are currently being used or may be developed soon. MDPI 2023-02-27 /pmc/articles/PMC10045384/ /pubmed/36979690 http://dx.doi.org/10.3390/biomedicines11030711 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Poznyak, Anastasia V.
Sukhorukov, Vasily N.
Eremin, Ilya I.
Nadelyaeva, Irina I.
Gutyrchik, Nikita A.
Orekhov, Alexander N.
HDL-Based Therapy: Vascular Protection at All Stages
title HDL-Based Therapy: Vascular Protection at All Stages
title_full HDL-Based Therapy: Vascular Protection at All Stages
title_fullStr HDL-Based Therapy: Vascular Protection at All Stages
title_full_unstemmed HDL-Based Therapy: Vascular Protection at All Stages
title_short HDL-Based Therapy: Vascular Protection at All Stages
title_sort hdl-based therapy: vascular protection at all stages
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045384/
https://www.ncbi.nlm.nih.gov/pubmed/36979690
http://dx.doi.org/10.3390/biomedicines11030711
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