Cargando…

Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives

Ischemia/reperfusion injury (IRI) is a multistep damage that occurs in several tissues when a blood flow interruption is inevitable, such as during organ surgery or transplantation. It is responsible for cell death and tissue dysfunction, thus leading, in the case of transplantation, to organ reject...

Descripción completa

Detalles Bibliográficos
Autores principales: Miceli, Vitale, Bulati, Matteo, Gallo, Alessia, Iannolo, Gioacchin, Busà, Rosalia, Conaldi, Pier Giulio, Zito, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045387/
https://www.ncbi.nlm.nih.gov/pubmed/36979668
http://dx.doi.org/10.3390/biomedicines11030689
_version_ 1784913591239966720
author Miceli, Vitale
Bulati, Matteo
Gallo, Alessia
Iannolo, Gioacchin
Busà, Rosalia
Conaldi, Pier Giulio
Zito, Giovanni
author_facet Miceli, Vitale
Bulati, Matteo
Gallo, Alessia
Iannolo, Gioacchin
Busà, Rosalia
Conaldi, Pier Giulio
Zito, Giovanni
author_sort Miceli, Vitale
collection PubMed
description Ischemia/reperfusion injury (IRI) is a multistep damage that occurs in several tissues when a blood flow interruption is inevitable, such as during organ surgery or transplantation. It is responsible for cell death and tissue dysfunction, thus leading, in the case of transplantation, to organ rejection. IRI takes place during reperfusion, i.e., when blood flow is restored, by activating inflammation and reactive oxygen species (ROS) production, causing mitochondrial damage and apoptosis of parenchymal cells. Unfortunately, none of the therapies currently in use are definitive, prompting the need for new therapeutic approaches. Scientific evidence has proven that mesenchymal stem/stromal cells (MSCs) can reduce inflammation and ROS, prompting this cellular therapy to also be investigated for treatment of IRI. Moreover, it has been shown that MSC therapeutic effects were mediated in part by their secretome, which appears to be involved in immune regulation and tissue repair. For these reasons, mediated MSC paracrine function might be key for injury amelioration upon IRI damage. In this review, we highlight the scientific literature on the potential beneficial use of MSCs and their products for improving IRI outcomes in different tissues/organs, focusing in particular on the paracrine effects mediated by MSCs, and on the molecular mechanisms behind these effects.
format Online
Article
Text
id pubmed-10045387
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100453872023-03-29 Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives Miceli, Vitale Bulati, Matteo Gallo, Alessia Iannolo, Gioacchin Busà, Rosalia Conaldi, Pier Giulio Zito, Giovanni Biomedicines Review Ischemia/reperfusion injury (IRI) is a multistep damage that occurs in several tissues when a blood flow interruption is inevitable, such as during organ surgery or transplantation. It is responsible for cell death and tissue dysfunction, thus leading, in the case of transplantation, to organ rejection. IRI takes place during reperfusion, i.e., when blood flow is restored, by activating inflammation and reactive oxygen species (ROS) production, causing mitochondrial damage and apoptosis of parenchymal cells. Unfortunately, none of the therapies currently in use are definitive, prompting the need for new therapeutic approaches. Scientific evidence has proven that mesenchymal stem/stromal cells (MSCs) can reduce inflammation and ROS, prompting this cellular therapy to also be investigated for treatment of IRI. Moreover, it has been shown that MSC therapeutic effects were mediated in part by their secretome, which appears to be involved in immune regulation and tissue repair. For these reasons, mediated MSC paracrine function might be key for injury amelioration upon IRI damage. In this review, we highlight the scientific literature on the potential beneficial use of MSCs and their products for improving IRI outcomes in different tissues/organs, focusing in particular on the paracrine effects mediated by MSCs, and on the molecular mechanisms behind these effects. MDPI 2023-02-23 /pmc/articles/PMC10045387/ /pubmed/36979668 http://dx.doi.org/10.3390/biomedicines11030689 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Miceli, Vitale
Bulati, Matteo
Gallo, Alessia
Iannolo, Gioacchin
Busà, Rosalia
Conaldi, Pier Giulio
Zito, Giovanni
Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives
title Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives
title_full Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives
title_fullStr Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives
title_full_unstemmed Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives
title_short Role of Mesenchymal Stem/Stromal Cells in Modulating Ischemia/Reperfusion Injury: Current State of the Art and Future Perspectives
title_sort role of mesenchymal stem/stromal cells in modulating ischemia/reperfusion injury: current state of the art and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045387/
https://www.ncbi.nlm.nih.gov/pubmed/36979668
http://dx.doi.org/10.3390/biomedicines11030689
work_keys_str_mv AT micelivitale roleofmesenchymalstemstromalcellsinmodulatingischemiareperfusioninjurycurrentstateoftheartandfutureperspectives
AT bulatimatteo roleofmesenchymalstemstromalcellsinmodulatingischemiareperfusioninjurycurrentstateoftheartandfutureperspectives
AT galloalessia roleofmesenchymalstemstromalcellsinmodulatingischemiareperfusioninjurycurrentstateoftheartandfutureperspectives
AT iannologioacchin roleofmesenchymalstemstromalcellsinmodulatingischemiareperfusioninjurycurrentstateoftheartandfutureperspectives
AT busarosalia roleofmesenchymalstemstromalcellsinmodulatingischemiareperfusioninjurycurrentstateoftheartandfutureperspectives
AT conaldipiergiulio roleofmesenchymalstemstromalcellsinmodulatingischemiareperfusioninjurycurrentstateoftheartandfutureperspectives
AT zitogiovanni roleofmesenchymalstemstromalcellsinmodulatingischemiareperfusioninjurycurrentstateoftheartandfutureperspectives