Cargando…

Bidirectional Relationship between Glycemic Control and COVID-19 and Perspectives of Islet Organoid Models of SARS-CoV-2 Infection

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to morbidity and mortality, with several clinical manifestations, and has caused a widespread pandemic. It has been found that type 2 diabetes is a risk factor for severe coronavirus disease 2019 (COVID-19) illness. Mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Tongran, Wang, Nannan, Zhu, Lingqiang, Chen, Lihua, Liu, Huisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045433/
https://www.ncbi.nlm.nih.gov/pubmed/36979836
http://dx.doi.org/10.3390/biomedicines11030856
_version_ 1784913602582413312
author Zhang, Tongran
Wang, Nannan
Zhu, Lingqiang
Chen, Lihua
Liu, Huisheng
author_facet Zhang, Tongran
Wang, Nannan
Zhu, Lingqiang
Chen, Lihua
Liu, Huisheng
author_sort Zhang, Tongran
collection PubMed
description Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to morbidity and mortality, with several clinical manifestations, and has caused a widespread pandemic. It has been found that type 2 diabetes is a risk factor for severe coronavirus disease 2019 (COVID-19) illness. Moreover, accumulating evidence has shown that SARS-CoV-2 infection can increase the risk of hyperglycemia and diabetes, though the underlying mechanism remains unclear because of a lack of authentic disease models to recapitulate the abnormalities involved in the development, regeneration, and function of human pancreatic islets under SARS-CoV-2 infection. Stem-cell-derived islet organoids have been valued as a model to study islets’ development and function, and thus provide a promising model for unraveling the mechanisms underlying the onset of diabetes under SARS-CoV-2 infection. This review summarized the latest results from clinical and basic research on SARS-CoV-2-induced pancreatic islet damage and impaired glycemic control. Furthermore, we discuss the potential and perspectives of using human ES/iPS cell-derived islet organoids to unravel the bidirectional relationship between glycemic control and SARS-CoV-2 infection.
format Online
Article
Text
id pubmed-10045433
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100454332023-03-29 Bidirectional Relationship between Glycemic Control and COVID-19 and Perspectives of Islet Organoid Models of SARS-CoV-2 Infection Zhang, Tongran Wang, Nannan Zhu, Lingqiang Chen, Lihua Liu, Huisheng Biomedicines Review Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to morbidity and mortality, with several clinical manifestations, and has caused a widespread pandemic. It has been found that type 2 diabetes is a risk factor for severe coronavirus disease 2019 (COVID-19) illness. Moreover, accumulating evidence has shown that SARS-CoV-2 infection can increase the risk of hyperglycemia and diabetes, though the underlying mechanism remains unclear because of a lack of authentic disease models to recapitulate the abnormalities involved in the development, regeneration, and function of human pancreatic islets under SARS-CoV-2 infection. Stem-cell-derived islet organoids have been valued as a model to study islets’ development and function, and thus provide a promising model for unraveling the mechanisms underlying the onset of diabetes under SARS-CoV-2 infection. This review summarized the latest results from clinical and basic research on SARS-CoV-2-induced pancreatic islet damage and impaired glycemic control. Furthermore, we discuss the potential and perspectives of using human ES/iPS cell-derived islet organoids to unravel the bidirectional relationship between glycemic control and SARS-CoV-2 infection. MDPI 2023-03-11 /pmc/articles/PMC10045433/ /pubmed/36979836 http://dx.doi.org/10.3390/biomedicines11030856 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Tongran
Wang, Nannan
Zhu, Lingqiang
Chen, Lihua
Liu, Huisheng
Bidirectional Relationship between Glycemic Control and COVID-19 and Perspectives of Islet Organoid Models of SARS-CoV-2 Infection
title Bidirectional Relationship between Glycemic Control and COVID-19 and Perspectives of Islet Organoid Models of SARS-CoV-2 Infection
title_full Bidirectional Relationship between Glycemic Control and COVID-19 and Perspectives of Islet Organoid Models of SARS-CoV-2 Infection
title_fullStr Bidirectional Relationship between Glycemic Control and COVID-19 and Perspectives of Islet Organoid Models of SARS-CoV-2 Infection
title_full_unstemmed Bidirectional Relationship between Glycemic Control and COVID-19 and Perspectives of Islet Organoid Models of SARS-CoV-2 Infection
title_short Bidirectional Relationship between Glycemic Control and COVID-19 and Perspectives of Islet Organoid Models of SARS-CoV-2 Infection
title_sort bidirectional relationship between glycemic control and covid-19 and perspectives of islet organoid models of sars-cov-2 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045433/
https://www.ncbi.nlm.nih.gov/pubmed/36979836
http://dx.doi.org/10.3390/biomedicines11030856
work_keys_str_mv AT zhangtongran bidirectionalrelationshipbetweenglycemiccontrolandcovid19andperspectivesofisletorganoidmodelsofsarscov2infection
AT wangnannan bidirectionalrelationshipbetweenglycemiccontrolandcovid19andperspectivesofisletorganoidmodelsofsarscov2infection
AT zhulingqiang bidirectionalrelationshipbetweenglycemiccontrolandcovid19andperspectivesofisletorganoidmodelsofsarscov2infection
AT chenlihua bidirectionalrelationshipbetweenglycemiccontrolandcovid19andperspectivesofisletorganoidmodelsofsarscov2infection
AT liuhuisheng bidirectionalrelationshipbetweenglycemiccontrolandcovid19andperspectivesofisletorganoidmodelsofsarscov2infection