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Hyperlipidemia and Cardiovascular Risk in Children and Adolescents

Atherosclerotic cardiovascular disease (ASCVD) represents the major cause of morbidity and mortality worldwide. The onset of the atherosclerosis process occurs during childhood and adolescence, subsequently leading to the onset of cardiovascular disease as young adults. Several cardiovascular risk f...

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Autores principales: Mainieri, Francesca, La Bella, Saverio, Chiarelli, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045454/
https://www.ncbi.nlm.nih.gov/pubmed/36979789
http://dx.doi.org/10.3390/biomedicines11030809
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author Mainieri, Francesca
La Bella, Saverio
Chiarelli, Francesco
author_facet Mainieri, Francesca
La Bella, Saverio
Chiarelli, Francesco
author_sort Mainieri, Francesca
collection PubMed
description Atherosclerotic cardiovascular disease (ASCVD) represents the major cause of morbidity and mortality worldwide. The onset of the atherosclerosis process occurs during childhood and adolescence, subsequently leading to the onset of cardiovascular disease as young adults. Several cardiovascular risk factors can be identified in children and adolescents; however, hyperlipidemia, in conjunction with the global obesity epidemic, has emerged as the most prevalent, playing a key role in the development of ASCVD. Therefore, screening for hyperlipidemia is strongly recommended to detect high-risk children presenting with these disorders, as these patients deserve more intensive investigation and intervention. Treatment should be initiated as early as possible in order to reduce the risk of future ASCVD. In this review, we will discuss lipid metabolism and hyperlipidemia, focusing on correlations with cardiovascular risk and screening and therapeutic management to reduce or almost completely avoid the development of ASCVD.
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spelling pubmed-100454542023-03-29 Hyperlipidemia and Cardiovascular Risk in Children and Adolescents Mainieri, Francesca La Bella, Saverio Chiarelli, Francesco Biomedicines Review Atherosclerotic cardiovascular disease (ASCVD) represents the major cause of morbidity and mortality worldwide. The onset of the atherosclerosis process occurs during childhood and adolescence, subsequently leading to the onset of cardiovascular disease as young adults. Several cardiovascular risk factors can be identified in children and adolescents; however, hyperlipidemia, in conjunction with the global obesity epidemic, has emerged as the most prevalent, playing a key role in the development of ASCVD. Therefore, screening for hyperlipidemia is strongly recommended to detect high-risk children presenting with these disorders, as these patients deserve more intensive investigation and intervention. Treatment should be initiated as early as possible in order to reduce the risk of future ASCVD. In this review, we will discuss lipid metabolism and hyperlipidemia, focusing on correlations with cardiovascular risk and screening and therapeutic management to reduce or almost completely avoid the development of ASCVD. MDPI 2023-03-07 /pmc/articles/PMC10045454/ /pubmed/36979789 http://dx.doi.org/10.3390/biomedicines11030809 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mainieri, Francesca
La Bella, Saverio
Chiarelli, Francesco
Hyperlipidemia and Cardiovascular Risk in Children and Adolescents
title Hyperlipidemia and Cardiovascular Risk in Children and Adolescents
title_full Hyperlipidemia and Cardiovascular Risk in Children and Adolescents
title_fullStr Hyperlipidemia and Cardiovascular Risk in Children and Adolescents
title_full_unstemmed Hyperlipidemia and Cardiovascular Risk in Children and Adolescents
title_short Hyperlipidemia and Cardiovascular Risk in Children and Adolescents
title_sort hyperlipidemia and cardiovascular risk in children and adolescents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045454/
https://www.ncbi.nlm.nih.gov/pubmed/36979789
http://dx.doi.org/10.3390/biomedicines11030809
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