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Hyperlipidemia and Cardiovascular Risk in Children and Adolescents
Atherosclerotic cardiovascular disease (ASCVD) represents the major cause of morbidity and mortality worldwide. The onset of the atherosclerosis process occurs during childhood and adolescence, subsequently leading to the onset of cardiovascular disease as young adults. Several cardiovascular risk f...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045454/ https://www.ncbi.nlm.nih.gov/pubmed/36979789 http://dx.doi.org/10.3390/biomedicines11030809 |
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author | Mainieri, Francesca La Bella, Saverio Chiarelli, Francesco |
author_facet | Mainieri, Francesca La Bella, Saverio Chiarelli, Francesco |
author_sort | Mainieri, Francesca |
collection | PubMed |
description | Atherosclerotic cardiovascular disease (ASCVD) represents the major cause of morbidity and mortality worldwide. The onset of the atherosclerosis process occurs during childhood and adolescence, subsequently leading to the onset of cardiovascular disease as young adults. Several cardiovascular risk factors can be identified in children and adolescents; however, hyperlipidemia, in conjunction with the global obesity epidemic, has emerged as the most prevalent, playing a key role in the development of ASCVD. Therefore, screening for hyperlipidemia is strongly recommended to detect high-risk children presenting with these disorders, as these patients deserve more intensive investigation and intervention. Treatment should be initiated as early as possible in order to reduce the risk of future ASCVD. In this review, we will discuss lipid metabolism and hyperlipidemia, focusing on correlations with cardiovascular risk and screening and therapeutic management to reduce or almost completely avoid the development of ASCVD. |
format | Online Article Text |
id | pubmed-10045454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100454542023-03-29 Hyperlipidemia and Cardiovascular Risk in Children and Adolescents Mainieri, Francesca La Bella, Saverio Chiarelli, Francesco Biomedicines Review Atherosclerotic cardiovascular disease (ASCVD) represents the major cause of morbidity and mortality worldwide. The onset of the atherosclerosis process occurs during childhood and adolescence, subsequently leading to the onset of cardiovascular disease as young adults. Several cardiovascular risk factors can be identified in children and adolescents; however, hyperlipidemia, in conjunction with the global obesity epidemic, has emerged as the most prevalent, playing a key role in the development of ASCVD. Therefore, screening for hyperlipidemia is strongly recommended to detect high-risk children presenting with these disorders, as these patients deserve more intensive investigation and intervention. Treatment should be initiated as early as possible in order to reduce the risk of future ASCVD. In this review, we will discuss lipid metabolism and hyperlipidemia, focusing on correlations with cardiovascular risk and screening and therapeutic management to reduce or almost completely avoid the development of ASCVD. MDPI 2023-03-07 /pmc/articles/PMC10045454/ /pubmed/36979789 http://dx.doi.org/10.3390/biomedicines11030809 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mainieri, Francesca La Bella, Saverio Chiarelli, Francesco Hyperlipidemia and Cardiovascular Risk in Children and Adolescents |
title | Hyperlipidemia and Cardiovascular Risk in Children and Adolescents |
title_full | Hyperlipidemia and Cardiovascular Risk in Children and Adolescents |
title_fullStr | Hyperlipidemia and Cardiovascular Risk in Children and Adolescents |
title_full_unstemmed | Hyperlipidemia and Cardiovascular Risk in Children and Adolescents |
title_short | Hyperlipidemia and Cardiovascular Risk in Children and Adolescents |
title_sort | hyperlipidemia and cardiovascular risk in children and adolescents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045454/ https://www.ncbi.nlm.nih.gov/pubmed/36979789 http://dx.doi.org/10.3390/biomedicines11030809 |
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