Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease

Nonsense-mediated mRNA decay (NMD) is a cellular surveillance mechanism that degrades mRNAs with a premature stop codon, avoiding the synthesis of C-terminally truncated proteins. In addition to faulty mRNAs, NMD recognises ~10% of endogenous transcripts in human cells and downregulates their expres...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Lingling, Mailliot, Justine, Schaffitzel, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045457/
https://www.ncbi.nlm.nih.gov/pubmed/36979701
http://dx.doi.org/10.3390/biomedicines11030722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045457/
https://www.ncbi.nlm.nih.gov/pubmed/36979701
http://dx.doi.org/10.3390/biomedicines11030722

Ejemplares similares