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Circle(s) of Life: The Circadian Clock from Birth to Death
SIMPLE SUMMARY: The circadian clock is a prominent regulator of physiology. Most studies so far have investigated its role in health and disease in adult subjects and animals. However, circadian clock characteristics change over one’s lifetime. This review describes how the clock develops during pre...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045474/ https://www.ncbi.nlm.nih.gov/pubmed/36979075 http://dx.doi.org/10.3390/biology12030383 |
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author | Olejniczak, Iwona Pilorz, Violetta Oster, Henrik |
author_facet | Olejniczak, Iwona Pilorz, Violetta Oster, Henrik |
author_sort | Olejniczak, Iwona |
collection | PubMed |
description | SIMPLE SUMMARY: The circadian clock is a prominent regulator of physiology. Most studies so far have investigated its role in health and disease in adult subjects and animals. However, circadian clock characteristics change over one’s lifetime. This review describes how the clock develops during pregnancy and infancy, how it evolves in childhood and adolescence and, finally, how its function is impacted by aging, with a special focus on the female reproductive system. Understanding those changes can contribute to adapting behavioral and medical interventions to the patients’ age and sex-specific needs. ABSTRACT: Most lifeforms on earth use endogenous, so-called circadian clocks to adapt to 24-h cycles in environmental demands driven by the planet’s rotation around its axis. Interactions with the environment change over the course of a lifetime, and so does regulation of the circadian clock system. In this review, we summarize how circadian clocks develop in humans and experimental rodents during embryonic development, how they mature after birth and what changes occur during puberty, adolescence and with increasing age. Special emphasis is laid on the circadian regulation of reproductive systems as major organizers of life segments and life span. We discuss differences in sexes and outline potential areas for future research. Finally, potential options for medical applications of lifespan chronobiology are discussed. |
format | Online Article Text |
id | pubmed-10045474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100454742023-03-29 Circle(s) of Life: The Circadian Clock from Birth to Death Olejniczak, Iwona Pilorz, Violetta Oster, Henrik Biology (Basel) Review SIMPLE SUMMARY: The circadian clock is a prominent regulator of physiology. Most studies so far have investigated its role in health and disease in adult subjects and animals. However, circadian clock characteristics change over one’s lifetime. This review describes how the clock develops during pregnancy and infancy, how it evolves in childhood and adolescence and, finally, how its function is impacted by aging, with a special focus on the female reproductive system. Understanding those changes can contribute to adapting behavioral and medical interventions to the patients’ age and sex-specific needs. ABSTRACT: Most lifeforms on earth use endogenous, so-called circadian clocks to adapt to 24-h cycles in environmental demands driven by the planet’s rotation around its axis. Interactions with the environment change over the course of a lifetime, and so does regulation of the circadian clock system. In this review, we summarize how circadian clocks develop in humans and experimental rodents during embryonic development, how they mature after birth and what changes occur during puberty, adolescence and with increasing age. Special emphasis is laid on the circadian regulation of reproductive systems as major organizers of life segments and life span. We discuss differences in sexes and outline potential areas for future research. Finally, potential options for medical applications of lifespan chronobiology are discussed. MDPI 2023-02-28 /pmc/articles/PMC10045474/ /pubmed/36979075 http://dx.doi.org/10.3390/biology12030383 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Olejniczak, Iwona Pilorz, Violetta Oster, Henrik Circle(s) of Life: The Circadian Clock from Birth to Death |
title | Circle(s) of Life: The Circadian Clock from Birth to Death |
title_full | Circle(s) of Life: The Circadian Clock from Birth to Death |
title_fullStr | Circle(s) of Life: The Circadian Clock from Birth to Death |
title_full_unstemmed | Circle(s) of Life: The Circadian Clock from Birth to Death |
title_short | Circle(s) of Life: The Circadian Clock from Birth to Death |
title_sort | circle(s) of life: the circadian clock from birth to death |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045474/ https://www.ncbi.nlm.nih.gov/pubmed/36979075 http://dx.doi.org/10.3390/biology12030383 |
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