Cargando…

Role of Cystathionine β-Synthase and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics of Murine Breast Cancer Cells

Cystathionine β-synthase (CBS), CSE (cystathionine γ-lyase) and 3-mercaptopyruvate sulfurtransferase (3-MST) have emerged as three significant sources of hydrogen sulfide (H(2)S) in various forms of mammalian cancer. Here, we investigated the functional role of CBS’ and 3-MST’s catalytic activity in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santos, Sidneia Sousa, Rodrigues, Larissa de Oliveira Cavalcanti Peres, Martins, Vanessa, Petrosino, Maria, Zuhra, Karim, Ascenção, Kelly, Anand, Abhishek, Abdel-Kader, Reham Mahmoud, Gad, Mohamed Z., Bourquin, Carole, Szabo, Csaba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045476/ https://www.ncbi.nlm.nih.gov/pubmed/36978895 http://dx.doi.org/10.3390/antiox12030647

Ejemplares similares

Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase
por: Ahmad, Akbar, et al.
Publicado: (2016)

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells
por: Augsburger, Fiona, et al.
Publicado: (2020)

Inhibition of the 3-mercaptopyruvate sulfurtransferase—hydrogen sulfide system promotes cellular lipid accumulation
por: Casili, Giovanna, et al.
Publicado: (2022)

Regulation of CyR61 expression and release by 3-mercaptopyruvate sulfurtransferase in colon cancer cells
por: Ascenção, Kelly, et al.
Publicado: (2022)

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts
por: Panagaki, Theodora, et al.
Publicado: (2020)

3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells
por: Tao, Beibei, et al.
Publicado: (2017)

Expression of 3-Mercaptopyruvate Sulfurtransferase in the Mouse
por: Tomita, Masahiro, et al.
Publicado: (2016)

Differential Roles of Cystathionine Gamma-Lyase and Mercaptopyruvate Sulfurtransferase in Hapten-Induced Colitis and Contact Dermatitis in Mice
por: Akahoshi, Noriyuki, et al.
Publicado: (2023)

Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes
por: Panagaki, Theodora, et al.
Publicado: (2020)

The Expression and Activity of Rhodanese, 3-Mercaptopyruvate Sulfurtransferase, Cystathionine γ-Lyase in the Most Frequently Chosen Cellular Research Models
por: Kaczor-Kamińska, Marta, et al.
Publicado: (2021)

Emerging roles of cystathionine β-synthase in various forms of cancer
por: Ascenção, Kelly, et al.
Publicado: (2022)

Activation of 3-Mercaptopyruvate Sulfurtransferase by Glutaredoxin Reducing System
por: Nagahara, Noriyuki
Publicado: (2020)

Dual targeting of H(2)S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer
por: Nafea, Heba, et al.
Publicado: (2023)

N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells
por: Zuhra, Karim, et al.
Publicado: (2019)

Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition
por: Zuhra, Karim, et al.
Publicado: (2020)

Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease
por: Rao, Swetha Pavani, et al.
Publicado: (2023)

H(2)S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine
por: Petrosino, Maria, et al.
Publicado: (2022)

Arabidopsis thaliana 3-mercaptopyruvate sulfurtransferases interact with and are protected by reducing systems
por: Moseler, Anna, et al.
Publicado: (2021)

MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity
por: Katsouda, Antonia, et al.
Publicado: (2022)

Sulfurtransferases and Cystathionine Beta-Synthase Expression in Different Human Leukemia Cell Lines
por: Jurkowska, Halina, et al.
Publicado: (2022)

Hydrogen Sulfide From Cysteine Desulfurase, Not 3-Mercaptopyruvate Sulfurtransferase, Contributes to Sustaining Cell Growth and Bioenergetics in E. coli Under Anaerobic Conditions
por: Wang, Jun, et al.
Publicado: (2019)

The Human Mercaptopyruvate Sulfurtransferase TUM1 Is Involved in Moco Biosynthesis, Cytosolic tRNA Thiolation and Cellular Bioenergetics in Human Embryonic Kidney Cells
por: Ogunkola, Moses Olalekan, et al.
Publicado: (2023)

Identification of H(2)S(3) and H(2)S produced by 3-mercaptopyruvate sulfurtransferase in the brain
por: Kimura, Yuka, et al.
Publicado: (2015)

Brain 3-Mercaptopyruvate Sulfurtransferase (3MST): Cellular Localization and Downregulation after Acute Stroke
por: Zhao, Heng, et al.
Publicado: (2013)

Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo
por: Rao, Swetha Pavani, et al.
Publicado: (2022)

Novel Characterization of Antioxidant Enzyme, 3-Mercaptopyruvate Sulfurtransferase-Knockout Mice: Overexpression of the Evolutionarily-Related Enzyme Rhodanese
por: Nagahara, Noriyuki, et al.
Publicado: (2019)

Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway
por: Li, Meng, et al.
Publicado: (2018)

Cysteine Aminotransferase (CAT): A Pivotal Sponsor in Metabolic Remodeling and an Ally of 3-Mercaptopyruvate Sulfurtransferase (MST) in Cancer
por: Hipólito, Ana, et al.
Publicado: (2020)

The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H(2)S) pathway against experimental osteoarthritis
por: Nasi, Sonia, et al.
Publicado: (2020)

Mycobacterium tuberculosis CysA2 is a dual sulfurtransferase with activity against thiosulfate and 3-mercaptopyruvate and interacts with mammalian cells
por: Meza, A. N., et al.
Publicado: (2019)

Effect of S-Allyl –L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis
por: Bronowicka-Adamska, Patrycja, et al.
Publicado: (2020)

In silico screening, molecular dynamic simulations, and in vitro activity of selected natural compounds as an inhibitor of Leishmania donovani 3-mercaptopyruvate sulfurtransferase
por: Kant, Vishnu, et al.
Publicado: (2022)

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)
por: Asimakopoulou, Antonia, et al.
Publicado: (2013)

Overproduction of hydrogen sulfide, generated by cystathionine β-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome
por: Panagaki, Theodora, et al.
Publicado: (2022)

Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria
por: Nagahara, Noriyuki, et al.
Publicado: (2013)

Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria
por: Akahoshi, Noriyuki, et al.
Publicado: (2020)

Discovery and Mechanistic Characterization of Selective Inhibitors of H(2)S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide
por: Hanaoka, Kenjiro, et al.
Publicado: (2017)

Physiological concentrations of cyanide stimulate mitochondrial Complex IV and enhance cellular bioenergetics
por: Randi, Elisa B., et al.
Publicado: (2021)

Cystathionine β-Synthase in Physiology and Cancer
por: Zhu, Haoran, et al.
Publicado: (2018)

Role of the cystathionine β-synthase / H(2)S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome
por: Panagaki, Theodora, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s51qbg2p68bkma4q9gnhgsoc4a