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A transcriptomic pan-cancer signature for survival prognostication and prediction of immunotherapy response based on endothelial senescence

BACKGROUND: The microvascular endothelium inherently controls nutrient delivery, oxygen supply, and immune surveillance of malignant tumors, thus representing both biological prerequisite and therapeutic vulnerability in cancer. Recently, cellular senescence emerged as a fundamental characteristic o...

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Detalles Bibliográficos
Autores principales: Wu, Zhengquan, Uhl, Bernd, Gires, Olivier, Reichel, Christoph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045484/
https://www.ncbi.nlm.nih.gov/pubmed/36978029
http://dx.doi.org/10.1186/s12929-023-00915-5