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COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia

(1) Background: Acute COVID-19 infections produce alterations in the skeletal muscle, leading to acute sarcopenia, but the medium- and long-term consequences are still unknown. The aim of this study was to evaluate: (1) body composition; (2) muscle strength and the prevalence of sarcopenia; and (3)...

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Autores principales: López-Sampalo, Almudena, Cobos-Palacios, Lidia, Vilches-Pérez, Alberto, Sanz-Cánovas, Jaime, Vargas-Candela, Antonio, Mancebo-Sevilla, Juan José, Hernández-Negrín, Halbert, Gómez-Huelgas, Ricardo, Bernal-López, María Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045496/
https://www.ncbi.nlm.nih.gov/pubmed/36979712
http://dx.doi.org/10.3390/biomedicines11030733
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author López-Sampalo, Almudena
Cobos-Palacios, Lidia
Vilches-Pérez, Alberto
Sanz-Cánovas, Jaime
Vargas-Candela, Antonio
Mancebo-Sevilla, Juan José
Hernández-Negrín, Halbert
Gómez-Huelgas, Ricardo
Bernal-López, María Rosa
author_facet López-Sampalo, Almudena
Cobos-Palacios, Lidia
Vilches-Pérez, Alberto
Sanz-Cánovas, Jaime
Vargas-Candela, Antonio
Mancebo-Sevilla, Juan José
Hernández-Negrín, Halbert
Gómez-Huelgas, Ricardo
Bernal-López, María Rosa
author_sort López-Sampalo, Almudena
collection PubMed
description (1) Background: Acute COVID-19 infections produce alterations in the skeletal muscle, leading to acute sarcopenia, but the medium- and long-term consequences are still unknown. The aim of this study was to evaluate: (1) body composition; (2) muscle strength and the prevalence of sarcopenia; and (3) the relationship between muscle strength with symptomatic and functional evolution in older patients affected by/recovered from COVID-19; (2) Methods: A prospective, longitudinal study of patients aged ≥65 years who had suffered from COVID-19 infection between 1 March and 31 May 2020, as confirmed by PCR or subsequent seroconversion. Persistent symptoms, as well as anthropometric, clinical, and analytical characteristics, were analyzed at 3 and 12 months after infection. The degree of sarcopenia was determined by dynamometry and with SARC-F; (3) Results: 106 participants, aged 76.8 ± 7 years, were included. At 3 months postinfection, a high percentage of sarcopenic patients was found, especially among women and in those with hospitalization. At 12 months postinfection, this percentage had decreased, coinciding with a functional and symptomatic recovery, and the normalization of inflammatory parameters, especially interleukin-6 (4.7 ± 11.6 pg/mL vs. 1.5 ± 2.4 pg/mL, p < 0.05). The improvement in muscle strength was accompanied by significant weight gain (71.9 ± 12.1 kg vs. 74.7 ± 12.7 kg, p < 0.001), but not by an increase in lean mass (49.6 ± 10 vs. 49.9 ± 10, p 0.29); (4) Conclusions: Older COVID-19 survivors presented a functional, clinical, and muscular recovery 12 months postinfection. Even so, it is necessary to carry out comprehensive follow-ups and assessments that include aspects of nutrition and physical activity.
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spelling pubmed-100454962023-03-29 COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia López-Sampalo, Almudena Cobos-Palacios, Lidia Vilches-Pérez, Alberto Sanz-Cánovas, Jaime Vargas-Candela, Antonio Mancebo-Sevilla, Juan José Hernández-Negrín, Halbert Gómez-Huelgas, Ricardo Bernal-López, María Rosa Biomedicines Article (1) Background: Acute COVID-19 infections produce alterations in the skeletal muscle, leading to acute sarcopenia, but the medium- and long-term consequences are still unknown. The aim of this study was to evaluate: (1) body composition; (2) muscle strength and the prevalence of sarcopenia; and (3) the relationship between muscle strength with symptomatic and functional evolution in older patients affected by/recovered from COVID-19; (2) Methods: A prospective, longitudinal study of patients aged ≥65 years who had suffered from COVID-19 infection between 1 March and 31 May 2020, as confirmed by PCR or subsequent seroconversion. Persistent symptoms, as well as anthropometric, clinical, and analytical characteristics, were analyzed at 3 and 12 months after infection. The degree of sarcopenia was determined by dynamometry and with SARC-F; (3) Results: 106 participants, aged 76.8 ± 7 years, were included. At 3 months postinfection, a high percentage of sarcopenic patients was found, especially among women and in those with hospitalization. At 12 months postinfection, this percentage had decreased, coinciding with a functional and symptomatic recovery, and the normalization of inflammatory parameters, especially interleukin-6 (4.7 ± 11.6 pg/mL vs. 1.5 ± 2.4 pg/mL, p < 0.05). The improvement in muscle strength was accompanied by significant weight gain (71.9 ± 12.1 kg vs. 74.7 ± 12.7 kg, p < 0.001), but not by an increase in lean mass (49.6 ± 10 vs. 49.9 ± 10, p 0.29); (4) Conclusions: Older COVID-19 survivors presented a functional, clinical, and muscular recovery 12 months postinfection. Even so, it is necessary to carry out comprehensive follow-ups and assessments that include aspects of nutrition and physical activity. MDPI 2023-02-28 /pmc/articles/PMC10045496/ /pubmed/36979712 http://dx.doi.org/10.3390/biomedicines11030733 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
López-Sampalo, Almudena
Cobos-Palacios, Lidia
Vilches-Pérez, Alberto
Sanz-Cánovas, Jaime
Vargas-Candela, Antonio
Mancebo-Sevilla, Juan José
Hernández-Negrín, Halbert
Gómez-Huelgas, Ricardo
Bernal-López, María Rosa
COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia
title COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia
title_full COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia
title_fullStr COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia
title_full_unstemmed COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia
title_short COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia
title_sort covid-19 in older patients: assessment of post-covid-19 sarcopenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045496/
https://www.ncbi.nlm.nih.gov/pubmed/36979712
http://dx.doi.org/10.3390/biomedicines11030733
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