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COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia
(1) Background: Acute COVID-19 infections produce alterations in the skeletal muscle, leading to acute sarcopenia, but the medium- and long-term consequences are still unknown. The aim of this study was to evaluate: (1) body composition; (2) muscle strength and the prevalence of sarcopenia; and (3)...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045496/ https://www.ncbi.nlm.nih.gov/pubmed/36979712 http://dx.doi.org/10.3390/biomedicines11030733 |
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author | López-Sampalo, Almudena Cobos-Palacios, Lidia Vilches-Pérez, Alberto Sanz-Cánovas, Jaime Vargas-Candela, Antonio Mancebo-Sevilla, Juan José Hernández-Negrín, Halbert Gómez-Huelgas, Ricardo Bernal-López, María Rosa |
author_facet | López-Sampalo, Almudena Cobos-Palacios, Lidia Vilches-Pérez, Alberto Sanz-Cánovas, Jaime Vargas-Candela, Antonio Mancebo-Sevilla, Juan José Hernández-Negrín, Halbert Gómez-Huelgas, Ricardo Bernal-López, María Rosa |
author_sort | López-Sampalo, Almudena |
collection | PubMed |
description | (1) Background: Acute COVID-19 infections produce alterations in the skeletal muscle, leading to acute sarcopenia, but the medium- and long-term consequences are still unknown. The aim of this study was to evaluate: (1) body composition; (2) muscle strength and the prevalence of sarcopenia; and (3) the relationship between muscle strength with symptomatic and functional evolution in older patients affected by/recovered from COVID-19; (2) Methods: A prospective, longitudinal study of patients aged ≥65 years who had suffered from COVID-19 infection between 1 March and 31 May 2020, as confirmed by PCR or subsequent seroconversion. Persistent symptoms, as well as anthropometric, clinical, and analytical characteristics, were analyzed at 3 and 12 months after infection. The degree of sarcopenia was determined by dynamometry and with SARC-F; (3) Results: 106 participants, aged 76.8 ± 7 years, were included. At 3 months postinfection, a high percentage of sarcopenic patients was found, especially among women and in those with hospitalization. At 12 months postinfection, this percentage had decreased, coinciding with a functional and symptomatic recovery, and the normalization of inflammatory parameters, especially interleukin-6 (4.7 ± 11.6 pg/mL vs. 1.5 ± 2.4 pg/mL, p < 0.05). The improvement in muscle strength was accompanied by significant weight gain (71.9 ± 12.1 kg vs. 74.7 ± 12.7 kg, p < 0.001), but not by an increase in lean mass (49.6 ± 10 vs. 49.9 ± 10, p 0.29); (4) Conclusions: Older COVID-19 survivors presented a functional, clinical, and muscular recovery 12 months postinfection. Even so, it is necessary to carry out comprehensive follow-ups and assessments that include aspects of nutrition and physical activity. |
format | Online Article Text |
id | pubmed-10045496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100454962023-03-29 COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia López-Sampalo, Almudena Cobos-Palacios, Lidia Vilches-Pérez, Alberto Sanz-Cánovas, Jaime Vargas-Candela, Antonio Mancebo-Sevilla, Juan José Hernández-Negrín, Halbert Gómez-Huelgas, Ricardo Bernal-López, María Rosa Biomedicines Article (1) Background: Acute COVID-19 infections produce alterations in the skeletal muscle, leading to acute sarcopenia, but the medium- and long-term consequences are still unknown. The aim of this study was to evaluate: (1) body composition; (2) muscle strength and the prevalence of sarcopenia; and (3) the relationship between muscle strength with symptomatic and functional evolution in older patients affected by/recovered from COVID-19; (2) Methods: A prospective, longitudinal study of patients aged ≥65 years who had suffered from COVID-19 infection between 1 March and 31 May 2020, as confirmed by PCR or subsequent seroconversion. Persistent symptoms, as well as anthropometric, clinical, and analytical characteristics, were analyzed at 3 and 12 months after infection. The degree of sarcopenia was determined by dynamometry and with SARC-F; (3) Results: 106 participants, aged 76.8 ± 7 years, were included. At 3 months postinfection, a high percentage of sarcopenic patients was found, especially among women and in those with hospitalization. At 12 months postinfection, this percentage had decreased, coinciding with a functional and symptomatic recovery, and the normalization of inflammatory parameters, especially interleukin-6 (4.7 ± 11.6 pg/mL vs. 1.5 ± 2.4 pg/mL, p < 0.05). The improvement in muscle strength was accompanied by significant weight gain (71.9 ± 12.1 kg vs. 74.7 ± 12.7 kg, p < 0.001), but not by an increase in lean mass (49.6 ± 10 vs. 49.9 ± 10, p 0.29); (4) Conclusions: Older COVID-19 survivors presented a functional, clinical, and muscular recovery 12 months postinfection. Even so, it is necessary to carry out comprehensive follow-ups and assessments that include aspects of nutrition and physical activity. MDPI 2023-02-28 /pmc/articles/PMC10045496/ /pubmed/36979712 http://dx.doi.org/10.3390/biomedicines11030733 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article López-Sampalo, Almudena Cobos-Palacios, Lidia Vilches-Pérez, Alberto Sanz-Cánovas, Jaime Vargas-Candela, Antonio Mancebo-Sevilla, Juan José Hernández-Negrín, Halbert Gómez-Huelgas, Ricardo Bernal-López, María Rosa COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia |
title | COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia |
title_full | COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia |
title_fullStr | COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia |
title_full_unstemmed | COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia |
title_short | COVID-19 in Older Patients: Assessment of Post-COVID-19 Sarcopenia |
title_sort | covid-19 in older patients: assessment of post-covid-19 sarcopenia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045496/ https://www.ncbi.nlm.nih.gov/pubmed/36979712 http://dx.doi.org/10.3390/biomedicines11030733 |
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