Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands

TRPML3 (mucolipin 3, MCOLN3) is an endolysosomal cation channel belonging to the TRPML subfamily of transient receptor potential channels. Gain-of-function mutations in the Trpml3 gene cause deafness, circling behavior and coat color dilution in mice due to cell death of TRPML3-expressing hair cells...

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Detalles Bibliográficos
Autores principales: Spix, Barbara, Castiglioni, Andrew J., Remis, Natalie N., Flores, Emma N., Wartenberg, Philipp, Wyatt, Amanda, Boehm, Ulrich, Gudermann, Thomas, Biel, Martin, García-Añoveros, Jaime, Grimm, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045552/
https://www.ncbi.nlm.nih.gov/pubmed/36520788
http://dx.doi.org/10.1371/journal.pone.0278848

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