Novel, Blended Polymeric Microspheres for the Controlled Release of Methotrexate: Characterization and In Vivo Antifibrotic Studies

Low dose methotrexate (MTX) is known to effectively decrease type I collagen production in dermal fibroblasts, while increasing the matrix metalloproteinase-1 (MMP-1) production in vitro. For in vivo use as an antifibrotic agent on wounds, a linear and extended controlled release formulation of MTX...

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Detalles Bibliográficos
Autores principales: Nabai, Layla, Ghahary, Aziz, Jackson, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045572/
https://www.ncbi.nlm.nih.gov/pubmed/36978688
http://dx.doi.org/10.3390/bioengineering10030298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045572/
https://www.ncbi.nlm.nih.gov/pubmed/36978688
http://dx.doi.org/10.3390/bioengineering10030298

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