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Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery
Conjunctival fibrosis remains the major impediment to the success of glaucoma filtration surgery. Anti-metabolites remain the gold standard for mitigating post-surgical fibrosis, but they are associated with high complication rates and surgical failure rates. Establishing a more targeted approach to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045591/ https://www.ncbi.nlm.nih.gov/pubmed/36979636 http://dx.doi.org/10.3390/biomedicines11030657 |
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author | Shao, Christine G. Sinha, Nishant R. Mohan, Rajiv R. Webel, Aaron D. |
author_facet | Shao, Christine G. Sinha, Nishant R. Mohan, Rajiv R. Webel, Aaron D. |
author_sort | Shao, Christine G. |
collection | PubMed |
description | Conjunctival fibrosis remains the major impediment to the success of glaucoma filtration surgery. Anti-metabolites remain the gold standard for mitigating post-surgical fibrosis, but they are associated with high complication rates and surgical failure rates. Establishing a more targeted approach to attenuate conjunctival fibrosis may revolutionize the surgical approach to glaucoma. A new strategy is needed to prevent progressive tissue remodeling and formation of a fibrotic scar, subsequently increasing surgical success and reducing the prevalence of glaucoma-related vision loss. Advancements in our understanding of molecular signaling and biomechanical cues in the conjunctival tissue architecture are broadening the horizon for new therapies and biomaterials for the mitigation of fibrosis. This review aims to highlight the strategies and current state of promising future approaches for targeting fibrosis in glaucoma filtration surgery. |
format | Online Article Text |
id | pubmed-10045591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100455912023-03-29 Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery Shao, Christine G. Sinha, Nishant R. Mohan, Rajiv R. Webel, Aaron D. Biomedicines Review Conjunctival fibrosis remains the major impediment to the success of glaucoma filtration surgery. Anti-metabolites remain the gold standard for mitigating post-surgical fibrosis, but they are associated with high complication rates and surgical failure rates. Establishing a more targeted approach to attenuate conjunctival fibrosis may revolutionize the surgical approach to glaucoma. A new strategy is needed to prevent progressive tissue remodeling and formation of a fibrotic scar, subsequently increasing surgical success and reducing the prevalence of glaucoma-related vision loss. Advancements in our understanding of molecular signaling and biomechanical cues in the conjunctival tissue architecture are broadening the horizon for new therapies and biomaterials for the mitigation of fibrosis. This review aims to highlight the strategies and current state of promising future approaches for targeting fibrosis in glaucoma filtration surgery. MDPI 2023-02-21 /pmc/articles/PMC10045591/ /pubmed/36979636 http://dx.doi.org/10.3390/biomedicines11030657 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shao, Christine G. Sinha, Nishant R. Mohan, Rajiv R. Webel, Aaron D. Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery |
title | Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery |
title_full | Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery |
title_fullStr | Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery |
title_full_unstemmed | Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery |
title_short | Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery |
title_sort | novel therapies for the prevention of fibrosis in glaucoma filtration surgery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045591/ https://www.ncbi.nlm.nih.gov/pubmed/36979636 http://dx.doi.org/10.3390/biomedicines11030657 |
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