Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease

Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. The aim of this review is to summarize the pres...

Descripción completa

Detalles Bibliográficos
Autores principales: Dozio, Elena, Caldiroli, Lara, Molinari, Paolo, Castellano, Giuseppe, Delfrate, Nicholas Walter, Romanelli, Massimiliano Marco Corsi, Vettoretti, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045600/
https://www.ncbi.nlm.nih.gov/pubmed/36978832
http://dx.doi.org/10.3390/antiox12030584
_version_ 1784913644325175296
author Dozio, Elena
Caldiroli, Lara
Molinari, Paolo
Castellano, Giuseppe
Delfrate, Nicholas Walter
Romanelli, Massimiliano Marco Corsi
Vettoretti, Simone
author_facet Dozio, Elena
Caldiroli, Lara
Molinari, Paolo
Castellano, Giuseppe
Delfrate, Nicholas Walter
Romanelli, Massimiliano Marco Corsi
Vettoretti, Simone
author_sort Dozio, Elena
collection PubMed
description Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. The aim of this review is to summarize the present knowledge of AGEs in CKD onset and progression, also focusing on CKD-related disorders (cardiovascular diseases, sarcopenia, and nutritional imbalance) and CKD mortality. The role of AGEs as etiopathogenetic molecules, as well as potential markers of disease progression and/or therapeutic targets, will be discussed.
format Online
Article
Text
id pubmed-10045600
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100456002023-03-29 Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease Dozio, Elena Caldiroli, Lara Molinari, Paolo Castellano, Giuseppe Delfrate, Nicholas Walter Romanelli, Massimiliano Marco Corsi Vettoretti, Simone Antioxidants (Basel) Review Advanced glycation end products (AGEs) are aging products. In chronic kidney disease (CKD), AGEs accumulate due to the increased production, reduced excretion, and the imbalance between oxidant/antioxidant capacities. CKD is therefore a model of aging. The aim of this review is to summarize the present knowledge of AGEs in CKD onset and progression, also focusing on CKD-related disorders (cardiovascular diseases, sarcopenia, and nutritional imbalance) and CKD mortality. The role of AGEs as etiopathogenetic molecules, as well as potential markers of disease progression and/or therapeutic targets, will be discussed. MDPI 2023-02-26 /pmc/articles/PMC10045600/ /pubmed/36978832 http://dx.doi.org/10.3390/antiox12030584 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dozio, Elena
Caldiroli, Lara
Molinari, Paolo
Castellano, Giuseppe
Delfrate, Nicholas Walter
Romanelli, Massimiliano Marco Corsi
Vettoretti, Simone
Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease
title Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease
title_full Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease
title_fullStr Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease
title_full_unstemmed Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease
title_short Accelerated AGEing: The Impact of Advanced Glycation End Products on the Prognosis of Chronic Kidney Disease
title_sort accelerated ageing: the impact of advanced glycation end products on the prognosis of chronic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045600/
https://www.ncbi.nlm.nih.gov/pubmed/36978832
http://dx.doi.org/10.3390/antiox12030584
work_keys_str_mv AT dozioelena acceleratedageingtheimpactofadvancedglycationendproductsontheprognosisofchronickidneydisease
AT caldirolilara acceleratedageingtheimpactofadvancedglycationendproductsontheprognosisofchronickidneydisease
AT molinaripaolo acceleratedageingtheimpactofadvancedglycationendproductsontheprognosisofchronickidneydisease
AT castellanogiuseppe acceleratedageingtheimpactofadvancedglycationendproductsontheprognosisofchronickidneydisease
AT delfratenicholaswalter acceleratedageingtheimpactofadvancedglycationendproductsontheprognosisofchronickidneydisease
AT romanellimassimilianomarcocorsi acceleratedageingtheimpactofadvancedglycationendproductsontheprognosisofchronickidneydisease
AT vettorettisimone acceleratedageingtheimpactofadvancedglycationendproductsontheprognosisofchronickidneydisease

Ejemplares similares