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Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears
BACKGROUND: A comparison of changes in the long head of the biceps tendon for different types of rotator cuff tears has not been previously performed. Furthermore, the correlation between the thickening and degeneration of the long head of the biceps tendon and the cause of these changes have not be...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045614/ https://www.ncbi.nlm.nih.gov/pubmed/36973696 http://dx.doi.org/10.1186/s12891-023-06338-5 |
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author | Kajiwara, Daisuke Ochiai, Nobuyasu Hashimoto, Eiko Hirosawa, Naoya Akimoto, Koji Nojima, Daisuke Shimada, Yohei Ise, Shohei Ohtori, Seiji |
author_facet | Kajiwara, Daisuke Ochiai, Nobuyasu Hashimoto, Eiko Hirosawa, Naoya Akimoto, Koji Nojima, Daisuke Shimada, Yohei Ise, Shohei Ohtori, Seiji |
author_sort | Kajiwara, Daisuke |
collection | PubMed |
description | BACKGROUND: A comparison of changes in the long head of the biceps tendon for different types of rotator cuff tears has not been previously performed. Furthermore, the correlation between the thickening and degeneration of the long head of the biceps tendon and the cause of these changes have not been fully clarified. We evaluated the relationship between degenerative changes in the long head of the biceps tendon and rotator cuff tears in a rat model using imaging and histology. METHODS: Ninety-six 12-week-old Sprague–Dawley rats were divided into anterior (subscapularis tear), anterosuperior (subscapularis, supraspinatus, and infraspinatus tears), superior (supraspinatus and infraspinatus tears), and control groups. The long head of the biceps tendon was harvested at 4 or 12 weeks postoperatively. The cross-sectional areas of the intra- and extra-capsular components of the tendon were measured using micro-computed tomography, and the affected/normal ratio of the cross-sectional area was calculated. Masson’s trichrome staining and Alcian blue staining were performed for histologic analysis, with degenerative changes described using the modified Bonar scale. The correlation between the affected/normal ratio and Bonar scores was evaluated. RESULTS: The affected/normal ratio was higher for the anterior and anterosuperior groups than for the control group at 4 and 12 weeks. The ratio increased for the intra-articular portion in the superior group and for both the intra- and extra-articular portions in the anterior and anterosuperior groups. Degeneration considerably progressed in the anterior and anterosuperior groups compared with the control group from weeks 4 to 12 and was greater in the intra- than in the extra-articular portion. The ratio correlated with extracellular matrix score. CONCLUSIONS: Subscapularis tears were associated with progressive thickening and degeneration of the long head of the biceps tendon at 4 and 12 weeks postoperatively, which was more significant in the intra- than in the extra-articular portion. Histologic evaluation indicated that the extracellular matrix likely caused these degenerative changes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-023-06338-5. |
format | Online Article Text |
id | pubmed-10045614 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-100456142023-03-29 Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears Kajiwara, Daisuke Ochiai, Nobuyasu Hashimoto, Eiko Hirosawa, Naoya Akimoto, Koji Nojima, Daisuke Shimada, Yohei Ise, Shohei Ohtori, Seiji BMC Musculoskelet Disord Research BACKGROUND: A comparison of changes in the long head of the biceps tendon for different types of rotator cuff tears has not been previously performed. Furthermore, the correlation between the thickening and degeneration of the long head of the biceps tendon and the cause of these changes have not been fully clarified. We evaluated the relationship between degenerative changes in the long head of the biceps tendon and rotator cuff tears in a rat model using imaging and histology. METHODS: Ninety-six 12-week-old Sprague–Dawley rats were divided into anterior (subscapularis tear), anterosuperior (subscapularis, supraspinatus, and infraspinatus tears), superior (supraspinatus and infraspinatus tears), and control groups. The long head of the biceps tendon was harvested at 4 or 12 weeks postoperatively. The cross-sectional areas of the intra- and extra-capsular components of the tendon were measured using micro-computed tomography, and the affected/normal ratio of the cross-sectional area was calculated. Masson’s trichrome staining and Alcian blue staining were performed for histologic analysis, with degenerative changes described using the modified Bonar scale. The correlation between the affected/normal ratio and Bonar scores was evaluated. RESULTS: The affected/normal ratio was higher for the anterior and anterosuperior groups than for the control group at 4 and 12 weeks. The ratio increased for the intra-articular portion in the superior group and for both the intra- and extra-articular portions in the anterior and anterosuperior groups. Degeneration considerably progressed in the anterior and anterosuperior groups compared with the control group from weeks 4 to 12 and was greater in the intra- than in the extra-articular portion. The ratio correlated with extracellular matrix score. CONCLUSIONS: Subscapularis tears were associated with progressive thickening and degeneration of the long head of the biceps tendon at 4 and 12 weeks postoperatively, which was more significant in the intra- than in the extra-articular portion. Histologic evaluation indicated that the extracellular matrix likely caused these degenerative changes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-023-06338-5. BioMed Central 2023-03-27 /pmc/articles/PMC10045614/ /pubmed/36973696 http://dx.doi.org/10.1186/s12891-023-06338-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Kajiwara, Daisuke Ochiai, Nobuyasu Hashimoto, Eiko Hirosawa, Naoya Akimoto, Koji Nojima, Daisuke Shimada, Yohei Ise, Shohei Ohtori, Seiji Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears |
title | Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears |
title_full | Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears |
title_fullStr | Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears |
title_full_unstemmed | Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears |
title_short | Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears |
title_sort | imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045614/ https://www.ncbi.nlm.nih.gov/pubmed/36973696 http://dx.doi.org/10.1186/s12891-023-06338-5 |
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