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Evaluation of Four Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection with Nasopharyngeal Swabs

Owing to the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, the capacity of testing systems based on the gold standard real-time reverse transcription–polymerase chain reaction (rRT-PCR) is limited. Rapid antigen tests (RATs) can substantially contrib...

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Autores principales: Lim, Ho-Jae, Park, Min-Young, Baek, Young-Hyun, Lee, Hyeon-Seo, Kim, Inhee, Kwon, Youngjin, You, Youngshin, Nam, Kyoungwoo, Yang, Jae-Hyun, Kim, Min-Jin, Yu, Nae, Sohn, Yong-Hak, Park, Jung-Eun, Yang, Yong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045780/
https://www.ncbi.nlm.nih.gov/pubmed/36979680
http://dx.doi.org/10.3390/biomedicines11030701
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author Lim, Ho-Jae
Park, Min-Young
Baek, Young-Hyun
Lee, Hyeon-Seo
Kim, Inhee
Kwon, Youngjin
You, Youngshin
Nam, Kyoungwoo
Yang, Jae-Hyun
Kim, Min-Jin
Yu, Nae
Sohn, Yong-Hak
Park, Jung-Eun
Yang, Yong-Jin
author_facet Lim, Ho-Jae
Park, Min-Young
Baek, Young-Hyun
Lee, Hyeon-Seo
Kim, Inhee
Kwon, Youngjin
You, Youngshin
Nam, Kyoungwoo
Yang, Jae-Hyun
Kim, Min-Jin
Yu, Nae
Sohn, Yong-Hak
Park, Jung-Eun
Yang, Yong-Jin
author_sort Lim, Ho-Jae
collection PubMed
description Owing to the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, the capacity of testing systems based on the gold standard real-time reverse transcription–polymerase chain reaction (rRT-PCR) is limited. Rapid antigen tests (RATs) can substantially contribute to the prevention of community transmission, but their further assessment is required. Here, using 1503 nasopharyngeal swabs, we compared the diagnostic performance of four RAT kits (Abbott Panbio™ COVID-19 Ag Rapid Test, SD Biosensor Standard™ Q COVID-19 Ag Test, Humasis COVID-19 Ag Test, and SG Medical Acrosis COVID-19 Ag Test) to the cycle threshold (Ct) values obtained from rRT-PCR. The precision values, area under the curve values, SARS-CoV-2 variant detection ability, and non-SARS-CoV-2 specificity of all four kits were similar. An assay using the Acrosis kit had a significantly better positive detection rate with a higher recall value and cut-off value than that using the other three RAT kits. During the current COVID-19 pandemic, the Acrosis kit is an effective tool to prevent the spread of SARS-CoV-2 in communities.
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spelling pubmed-100457802023-03-29 Evaluation of Four Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection with Nasopharyngeal Swabs Lim, Ho-Jae Park, Min-Young Baek, Young-Hyun Lee, Hyeon-Seo Kim, Inhee Kwon, Youngjin You, Youngshin Nam, Kyoungwoo Yang, Jae-Hyun Kim, Min-Jin Yu, Nae Sohn, Yong-Hak Park, Jung-Eun Yang, Yong-Jin Biomedicines Article Owing to the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, the capacity of testing systems based on the gold standard real-time reverse transcription–polymerase chain reaction (rRT-PCR) is limited. Rapid antigen tests (RATs) can substantially contribute to the prevention of community transmission, but their further assessment is required. Here, using 1503 nasopharyngeal swabs, we compared the diagnostic performance of four RAT kits (Abbott Panbio™ COVID-19 Ag Rapid Test, SD Biosensor Standard™ Q COVID-19 Ag Test, Humasis COVID-19 Ag Test, and SG Medical Acrosis COVID-19 Ag Test) to the cycle threshold (Ct) values obtained from rRT-PCR. The precision values, area under the curve values, SARS-CoV-2 variant detection ability, and non-SARS-CoV-2 specificity of all four kits were similar. An assay using the Acrosis kit had a significantly better positive detection rate with a higher recall value and cut-off value than that using the other three RAT kits. During the current COVID-19 pandemic, the Acrosis kit is an effective tool to prevent the spread of SARS-CoV-2 in communities. MDPI 2023-02-24 /pmc/articles/PMC10045780/ /pubmed/36979680 http://dx.doi.org/10.3390/biomedicines11030701 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lim, Ho-Jae
Park, Min-Young
Baek, Young-Hyun
Lee, Hyeon-Seo
Kim, Inhee
Kwon, Youngjin
You, Youngshin
Nam, Kyoungwoo
Yang, Jae-Hyun
Kim, Min-Jin
Yu, Nae
Sohn, Yong-Hak
Park, Jung-Eun
Yang, Yong-Jin
Evaluation of Four Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection with Nasopharyngeal Swabs
title Evaluation of Four Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection with Nasopharyngeal Swabs
title_full Evaluation of Four Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection with Nasopharyngeal Swabs
title_fullStr Evaluation of Four Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection with Nasopharyngeal Swabs
title_full_unstemmed Evaluation of Four Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection with Nasopharyngeal Swabs
title_short Evaluation of Four Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection with Nasopharyngeal Swabs
title_sort evaluation of four rapid antigen tests for the detection of sars-cov-2 infection with nasopharyngeal swabs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045780/
https://www.ncbi.nlm.nih.gov/pubmed/36979680
http://dx.doi.org/10.3390/biomedicines11030701
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