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Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation
BET proteins function as histone code readers of acetylated lysins that determine the positive regulation in transcription of genes involved in cell cycle progression, differentiation, inflammation, and many other pathways. In recent years, thanks to the development of BET inhibitors, interest in th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045827/ https://www.ncbi.nlm.nih.gov/pubmed/36979729 http://dx.doi.org/10.3390/biomedicines11030750 |
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author | Martella, Noemi Pensabene, Daniele Varone, Michela Colardo, Mayra Petraroia, Michele Sergio, William La Rosa, Piergiorgio Moreno, Sandra Segatto, Marco |
author_facet | Martella, Noemi Pensabene, Daniele Varone, Michela Colardo, Mayra Petraroia, Michele Sergio, William La Rosa, Piergiorgio Moreno, Sandra Segatto, Marco |
author_sort | Martella, Noemi |
collection | PubMed |
description | BET proteins function as histone code readers of acetylated lysins that determine the positive regulation in transcription of genes involved in cell cycle progression, differentiation, inflammation, and many other pathways. In recent years, thanks to the development of BET inhibitors, interest in this protein family has risen for its relevance in brain development and function. For example, experimental evidence has shown that BET modulation affects neuronal activity and the expression of genes involved in learning and memory. In addition, BET inhibition strongly suppresses molecular pathways related to neuroinflammation. These observations suggest that BET modulation may play a critical role in the onset and during the development of diverse neurodegenerative and neuropsychiatric disorders, such as Alzheimer’s disease, fragile X syndrome, and Rett syndrome. In this review article, we summarize the most recent evidence regarding the involvement of BET proteins in brain physiology and pathology, as well as their pharmacological potential as targets for therapeutic purposes. |
format | Online Article Text |
id | pubmed-10045827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100458272023-03-29 Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation Martella, Noemi Pensabene, Daniele Varone, Michela Colardo, Mayra Petraroia, Michele Sergio, William La Rosa, Piergiorgio Moreno, Sandra Segatto, Marco Biomedicines Review BET proteins function as histone code readers of acetylated lysins that determine the positive regulation in transcription of genes involved in cell cycle progression, differentiation, inflammation, and many other pathways. In recent years, thanks to the development of BET inhibitors, interest in this protein family has risen for its relevance in brain development and function. For example, experimental evidence has shown that BET modulation affects neuronal activity and the expression of genes involved in learning and memory. In addition, BET inhibition strongly suppresses molecular pathways related to neuroinflammation. These observations suggest that BET modulation may play a critical role in the onset and during the development of diverse neurodegenerative and neuropsychiatric disorders, such as Alzheimer’s disease, fragile X syndrome, and Rett syndrome. In this review article, we summarize the most recent evidence regarding the involvement of BET proteins in brain physiology and pathology, as well as their pharmacological potential as targets for therapeutic purposes. MDPI 2023-03-01 /pmc/articles/PMC10045827/ /pubmed/36979729 http://dx.doi.org/10.3390/biomedicines11030750 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martella, Noemi Pensabene, Daniele Varone, Michela Colardo, Mayra Petraroia, Michele Sergio, William La Rosa, Piergiorgio Moreno, Sandra Segatto, Marco Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation |
title | Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation |
title_full | Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation |
title_fullStr | Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation |
title_full_unstemmed | Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation |
title_short | Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation |
title_sort | bromodomain and extra-terminal proteins in brain physiology and pathology: bet-ing on epigenetic regulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045827/ https://www.ncbi.nlm.nih.gov/pubmed/36979729 http://dx.doi.org/10.3390/biomedicines11030750 |
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