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Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review
Regenerative endodontic procedures (REPs) were used to recover the dental pulp’s vitality in order to avoid the undesirable outcomes of conventional endodontic treatment and to promote dentinal formation, especially for immature permanent teeth. Photobiomodulation therapy (PBMT) exhibits photobiolog...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045842/ https://www.ncbi.nlm.nih.gov/pubmed/36978762 http://dx.doi.org/10.3390/bioengineering10030371 |
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author | Yong, Jiawen Gröger, Sabine Wu, Zuping Ruf, Sabine Ye, Yuer Chen, Xiaoyan |
author_facet | Yong, Jiawen Gröger, Sabine Wu, Zuping Ruf, Sabine Ye, Yuer Chen, Xiaoyan |
author_sort | Yong, Jiawen |
collection | PubMed |
description | Regenerative endodontic procedures (REPs) were used to recover the dental pulp’s vitality in order to avoid the undesirable outcomes of conventional endodontic treatment and to promote dentinal formation, especially for immature permanent teeth. Photobiomodulation therapy (PBMT) exhibits photobiological and photochemical effects for improving the root canal’s environmental conditions by compensating for oxidative stress and increasing the blood supply to implanted stem cells and improving their survival. Basic research has revealed that PBMT can modulate human dental pulp stem cells’ (hDPSCs) differentiation, proliferation, and activity, and subsequent tissue activation. However, many unclear points still remain regarding the mechanisms of action induced by PBMT in REPs. Therefore, in this review, we present the applications of laser and PBMT irradiation to the procedures of REPs and in endodontics. In addition, the effects of PBMT on the regenerative processes of hDPSCs are reviewed from biochemical and cytological perspectives on the basis of the available literature. Furthermore, we consider the feasibility of treatment in which PBMT irradiation is applied to stem cells, including dental pulp stem cells, and we discuss research that has reported on its effect. |
format | Online Article Text |
id | pubmed-10045842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100458422023-03-29 Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review Yong, Jiawen Gröger, Sabine Wu, Zuping Ruf, Sabine Ye, Yuer Chen, Xiaoyan Bioengineering (Basel) Review Regenerative endodontic procedures (REPs) were used to recover the dental pulp’s vitality in order to avoid the undesirable outcomes of conventional endodontic treatment and to promote dentinal formation, especially for immature permanent teeth. Photobiomodulation therapy (PBMT) exhibits photobiological and photochemical effects for improving the root canal’s environmental conditions by compensating for oxidative stress and increasing the blood supply to implanted stem cells and improving their survival. Basic research has revealed that PBMT can modulate human dental pulp stem cells’ (hDPSCs) differentiation, proliferation, and activity, and subsequent tissue activation. However, many unclear points still remain regarding the mechanisms of action induced by PBMT in REPs. Therefore, in this review, we present the applications of laser and PBMT irradiation to the procedures of REPs and in endodontics. In addition, the effects of PBMT on the regenerative processes of hDPSCs are reviewed from biochemical and cytological perspectives on the basis of the available literature. Furthermore, we consider the feasibility of treatment in which PBMT irradiation is applied to stem cells, including dental pulp stem cells, and we discuss research that has reported on its effect. MDPI 2023-03-17 /pmc/articles/PMC10045842/ /pubmed/36978762 http://dx.doi.org/10.3390/bioengineering10030371 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yong, Jiawen Gröger, Sabine Wu, Zuping Ruf, Sabine Ye, Yuer Chen, Xiaoyan Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review |
title | Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review |
title_full | Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review |
title_fullStr | Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review |
title_full_unstemmed | Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review |
title_short | Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review |
title_sort | photobiomodulation therapy and pulp-regenerative endodontics: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045842/ https://www.ncbi.nlm.nih.gov/pubmed/36978762 http://dx.doi.org/10.3390/bioengineering10030371 |
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