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Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction

Menopause-related decline in estrogen levels is accompanied by a change in adipose tissue distribution from a gynoid to an android and an increased prevalence of obesity in women. These unfavorable phenomena can be partially restored by hormone replacement therapy, suggesting a significant role for...

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Autor principal: Kuryłowicz, Alina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045924/
https://www.ncbi.nlm.nih.gov/pubmed/36979669
http://dx.doi.org/10.3390/biomedicines11030690
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author Kuryłowicz, Alina
author_facet Kuryłowicz, Alina
author_sort Kuryłowicz, Alina
collection PubMed
description Menopause-related decline in estrogen levels is accompanied by a change in adipose tissue distribution from a gynoid to an android and an increased prevalence of obesity in women. These unfavorable phenomena can be partially restored by hormone replacement therapy, suggesting a significant role for estrogen in the regulation of adipocytes’ function. Indeed, preclinical studies proved the involvement of these hormones in adipose tissue development, metabolism, and inflammatory activity. However, the relationship between estrogen and obesity is bidirectional. On the one hand-their deficiency leads to excessive fat accumulation and impairs adipocyte function, on the other-adipose tissue of obese individuals is characterized by altered expression of estrogen receptors and key enzymes involved in their synthesis. This narrative review aims to summarize the role of estrogen in adipose tissue development, physiology, and in obesity-related dysfunction. Firstly, the estrogen classification, synthesis, and modes of action are presented. Next, their role in regulating adipogenesis and adipose tissue activity in health and the course of obesity is described. Finally, the potential therapeutic applications of estrogen and its derivates in obesity treatment are discussed.
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spelling pubmed-100459242023-03-29 Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction Kuryłowicz, Alina Biomedicines Review Menopause-related decline in estrogen levels is accompanied by a change in adipose tissue distribution from a gynoid to an android and an increased prevalence of obesity in women. These unfavorable phenomena can be partially restored by hormone replacement therapy, suggesting a significant role for estrogen in the regulation of adipocytes’ function. Indeed, preclinical studies proved the involvement of these hormones in adipose tissue development, metabolism, and inflammatory activity. However, the relationship between estrogen and obesity is bidirectional. On the one hand-their deficiency leads to excessive fat accumulation and impairs adipocyte function, on the other-adipose tissue of obese individuals is characterized by altered expression of estrogen receptors and key enzymes involved in their synthesis. This narrative review aims to summarize the role of estrogen in adipose tissue development, physiology, and in obesity-related dysfunction. Firstly, the estrogen classification, synthesis, and modes of action are presented. Next, their role in regulating adipogenesis and adipose tissue activity in health and the course of obesity is described. Finally, the potential therapeutic applications of estrogen and its derivates in obesity treatment are discussed. MDPI 2023-02-24 /pmc/articles/PMC10045924/ /pubmed/36979669 http://dx.doi.org/10.3390/biomedicines11030690 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kuryłowicz, Alina
Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
title Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
title_full Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
title_fullStr Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
title_full_unstemmed Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
title_short Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
title_sort estrogens in adipose tissue physiology and obesity-related dysfunction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045924/
https://www.ncbi.nlm.nih.gov/pubmed/36979669
http://dx.doi.org/10.3390/biomedicines11030690
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