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HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma

BACKGROUND: Although the aberrant activation of NOTCH1 pathway causes a malignant progression of renal cell carcinoma (RCC), the precise molecular mechanisms behind the potential action of pro-oncogenic NOTCH1/HES1 axis remain elusive. Here, we examined the role of tumor suppressive miR-138–2 in the...

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Detalles Bibliográficos
Autores principales:	Liu, Shuangjie, Dou, Lei, Miao, Miao, Man, Xiaojun, Wei, Baojun, Jiang, Zhaowei, Ouyang, Yongze, Ozaki, Toshinori, Yu, Meng, Zhu, Yuyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10045948/ https://www.ncbi.nlm.nih.gov/pubmed/36973704 http://dx.doi.org/10.1186/s13046-023-02625-0

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