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Risk of Acute Myocardial Infarction in Pneumoconiosis: Results from a Retrospective Cohort Study

Background: Pneumoconiosis (PCN) has several comorbidities, most notably pulmonary and cardiovascular diseases. However, much is still unknown about the relationship between PCN and acute myocardial infarction (AMI). The present study aimed to clarify the association between PCN and subsequent AMI r...

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Autores principales: Chang, Ju-Hsin, Shen, Te-Chun, Chen, Ke-Wei, Lin, Cheng-Li, Hsu, Chung Y., Wen, Yeong-Ray, Chang, Kuan-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046008/
https://www.ncbi.nlm.nih.gov/pubmed/36979875
http://dx.doi.org/10.3390/biomedicines11030897
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author Chang, Ju-Hsin
Shen, Te-Chun
Chen, Ke-Wei
Lin, Cheng-Li
Hsu, Chung Y.
Wen, Yeong-Ray
Chang, Kuan-Cheng
author_facet Chang, Ju-Hsin
Shen, Te-Chun
Chen, Ke-Wei
Lin, Cheng-Li
Hsu, Chung Y.
Wen, Yeong-Ray
Chang, Kuan-Cheng
author_sort Chang, Ju-Hsin
collection PubMed
description Background: Pneumoconiosis (PCN) has several comorbidities, most notably pulmonary and cardiovascular diseases. However, much is still unknown about the relationship between PCN and acute myocardial infarction (AMI). The present study aimed to clarify the association between PCN and subsequent AMI risk using a retrospective cohort study design. Methods: This was a population-based, retrospective cohort study that used data from Taiwan’s National Health Insurance Database. A total of 7556 newly diagnosed patients with PCN and 7556 individuals without PCN were included in the PCN and comparison cohort (PC and CC), respectively, between 2008 and 2018, with propensity score matching for age, gender, comorbidity, medication, and date of PCN diagnosis. The occurrence of AMI was monitored until the end of 2019, and AMI risk was assessed using Cox proportional hazard regression models. Results: The overall incidence of AMI was 1.34-fold higher in the PC than in the CC (4.33 vs. 3.23 per 1000 person-years, respectively, p < 0.05), with an adjusted hazard ratio (aHR) of 1.36 (95% confidence interval (CI): 1.08–1.72) after controlling for age, gender, comorbidity, and medication. Further analyses showed a higher risk of AMI with increased annual number of emergency department visits among patients with PCN (aHR: 1.30, 95% CI: 1.01–1.66 (<1) and aHR: 1.68, 95% CI: 1.13–2.50 (≥1)). Conclusion: Patients with PCN had a significantly higher risk of developing AMI than those without PCN. Clinicians should pay more attention to prevent AMI episodes in patients with PCN.
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spelling pubmed-100460082023-03-29 Risk of Acute Myocardial Infarction in Pneumoconiosis: Results from a Retrospective Cohort Study Chang, Ju-Hsin Shen, Te-Chun Chen, Ke-Wei Lin, Cheng-Li Hsu, Chung Y. Wen, Yeong-Ray Chang, Kuan-Cheng Biomedicines Article Background: Pneumoconiosis (PCN) has several comorbidities, most notably pulmonary and cardiovascular diseases. However, much is still unknown about the relationship between PCN and acute myocardial infarction (AMI). The present study aimed to clarify the association between PCN and subsequent AMI risk using a retrospective cohort study design. Methods: This was a population-based, retrospective cohort study that used data from Taiwan’s National Health Insurance Database. A total of 7556 newly diagnosed patients with PCN and 7556 individuals without PCN were included in the PCN and comparison cohort (PC and CC), respectively, between 2008 and 2018, with propensity score matching for age, gender, comorbidity, medication, and date of PCN diagnosis. The occurrence of AMI was monitored until the end of 2019, and AMI risk was assessed using Cox proportional hazard regression models. Results: The overall incidence of AMI was 1.34-fold higher in the PC than in the CC (4.33 vs. 3.23 per 1000 person-years, respectively, p < 0.05), with an adjusted hazard ratio (aHR) of 1.36 (95% confidence interval (CI): 1.08–1.72) after controlling for age, gender, comorbidity, and medication. Further analyses showed a higher risk of AMI with increased annual number of emergency department visits among patients with PCN (aHR: 1.30, 95% CI: 1.01–1.66 (<1) and aHR: 1.68, 95% CI: 1.13–2.50 (≥1)). Conclusion: Patients with PCN had a significantly higher risk of developing AMI than those without PCN. Clinicians should pay more attention to prevent AMI episodes in patients with PCN. MDPI 2023-03-14 /pmc/articles/PMC10046008/ /pubmed/36979875 http://dx.doi.org/10.3390/biomedicines11030897 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Ju-Hsin
Shen, Te-Chun
Chen, Ke-Wei
Lin, Cheng-Li
Hsu, Chung Y.
Wen, Yeong-Ray
Chang, Kuan-Cheng
Risk of Acute Myocardial Infarction in Pneumoconiosis: Results from a Retrospective Cohort Study
title Risk of Acute Myocardial Infarction in Pneumoconiosis: Results from a Retrospective Cohort Study
title_full Risk of Acute Myocardial Infarction in Pneumoconiosis: Results from a Retrospective Cohort Study
title_fullStr Risk of Acute Myocardial Infarction in Pneumoconiosis: Results from a Retrospective Cohort Study
title_full_unstemmed Risk of Acute Myocardial Infarction in Pneumoconiosis: Results from a Retrospective Cohort Study
title_short Risk of Acute Myocardial Infarction in Pneumoconiosis: Results from a Retrospective Cohort Study
title_sort risk of acute myocardial infarction in pneumoconiosis: results from a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046008/
https://www.ncbi.nlm.nih.gov/pubmed/36979875
http://dx.doi.org/10.3390/biomedicines11030897
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