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TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation
Coregistration of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) allows non-invasive probing of brain circuits: TMS induces brain activation due to the generation of a properly oriented focused electric field (E-field) using a coil placed on a selected position over the sca...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046030/ https://www.ncbi.nlm.nih.gov/pubmed/36979228 http://dx.doi.org/10.3390/brainsci13030418 |
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author | Pieramico, Giulia Guidotti, Roberto Nieminen, Aino E. D’Andrea, Antea Basti, Alessio Souza, Victor H. Nieminen, Jaakko O. Lioumis, Pantelis Ilmoniemi, Risto J. Romani, Gian Luca Pizzella, Vittorio Marzetti, Laura |
author_facet | Pieramico, Giulia Guidotti, Roberto Nieminen, Aino E. D’Andrea, Antea Basti, Alessio Souza, Victor H. Nieminen, Jaakko O. Lioumis, Pantelis Ilmoniemi, Risto J. Romani, Gian Luca Pizzella, Vittorio Marzetti, Laura |
author_sort | Pieramico, Giulia |
collection | PubMed |
description | Coregistration of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) allows non-invasive probing of brain circuits: TMS induces brain activation due to the generation of a properly oriented focused electric field (E-field) using a coil placed on a selected position over the scalp, while EEG captures the effects of the stimulation on brain electrical activity. Moreover, the combination of these techniques allows the investigation of several brain properties, including brain functional connectivity. The choice of E-field parameters, such as intensity, orientation, and position, is crucial for eliciting cortex-specific effects. Here, we evaluated whether and how the spatial pattern, i.e., topography and strength of functional connectivity, is modulated by the stimulus orientation. We systematically altered the E-field orientation when stimulating the left pre-supplementary motor area and showed an increase of functional connectivity in areas associated with the primary motor cortex and an E-field orientation-specific modulation of functional connectivity intensity. |
format | Online Article Text |
id | pubmed-10046030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100460302023-03-29 TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation Pieramico, Giulia Guidotti, Roberto Nieminen, Aino E. D’Andrea, Antea Basti, Alessio Souza, Victor H. Nieminen, Jaakko O. Lioumis, Pantelis Ilmoniemi, Risto J. Romani, Gian Luca Pizzella, Vittorio Marzetti, Laura Brain Sci Article Coregistration of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) allows non-invasive probing of brain circuits: TMS induces brain activation due to the generation of a properly oriented focused electric field (E-field) using a coil placed on a selected position over the scalp, while EEG captures the effects of the stimulation on brain electrical activity. Moreover, the combination of these techniques allows the investigation of several brain properties, including brain functional connectivity. The choice of E-field parameters, such as intensity, orientation, and position, is crucial for eliciting cortex-specific effects. Here, we evaluated whether and how the spatial pattern, i.e., topography and strength of functional connectivity, is modulated by the stimulus orientation. We systematically altered the E-field orientation when stimulating the left pre-supplementary motor area and showed an increase of functional connectivity in areas associated with the primary motor cortex and an E-field orientation-specific modulation of functional connectivity intensity. MDPI 2023-02-28 /pmc/articles/PMC10046030/ /pubmed/36979228 http://dx.doi.org/10.3390/brainsci13030418 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pieramico, Giulia Guidotti, Roberto Nieminen, Aino E. D’Andrea, Antea Basti, Alessio Souza, Victor H. Nieminen, Jaakko O. Lioumis, Pantelis Ilmoniemi, Risto J. Romani, Gian Luca Pizzella, Vittorio Marzetti, Laura TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation |
title | TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation |
title_full | TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation |
title_fullStr | TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation |
title_full_unstemmed | TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation |
title_short | TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation |
title_sort | tms-induced modulation of eeg functional connectivity is affected by the e-field orientation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046030/ https://www.ncbi.nlm.nih.gov/pubmed/36979228 http://dx.doi.org/10.3390/brainsci13030418 |
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