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The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets

Sarcoma is a heterogeneous group of mesenchymal neoplasms with a high rate of lung metastasis. The cellular mechanisms responsible for sarcoma metastasis remain poorly understood. Furthermore, there are limited efficacious therapeutic strategies for treating metastatic sarcoma. Improved diagnostic a...

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Detalles Bibliográficos
Autores principales: Tan, Linyun, Wang, Yitian, Hu, Xin, Min, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046038/
https://www.ncbi.nlm.nih.gov/pubmed/36979391
http://dx.doi.org/10.3390/biom13030456
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author Tan, Linyun
Wang, Yitian
Hu, Xin
Min, Li
author_facet Tan, Linyun
Wang, Yitian
Hu, Xin
Min, Li
author_sort Tan, Linyun
collection PubMed
description Sarcoma is a heterogeneous group of mesenchymal neoplasms with a high rate of lung metastasis. The cellular mechanisms responsible for sarcoma metastasis remain poorly understood. Furthermore, there are limited efficacious therapeutic strategies for treating metastatic sarcoma. Improved diagnostic and therapeutic modalities are of increasing importance for the treatment of sarcoma due to their high mortality in the advanced stages of the disease. Recent evidence demonstrates that the exosome, a type of extracellular vesicle released by virtually all cells in the body, is an important facilitator of intercellular communication between the cells and the surrounding environment. The exosome is gaining significant attention among the medical research community, but there is little knowledge about how the exosome affects sarcoma metastasis. In this review, we summarize the multifaceted roles of sarcoma-derived exosomes in promoting the process of metastasis via the formation of pre-metastatic niche (PMN), the regulation of immunity, angiogenesis, vascular permeability, and the migration of sarcoma cells. We also highlight the potential of exosomes as innovative diagnostic and prognostic biomarkers as well as therapeutic targets in sarcoma metastasis.
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spelling pubmed-100460382023-03-29 The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets Tan, Linyun Wang, Yitian Hu, Xin Min, Li Biomolecules Review Sarcoma is a heterogeneous group of mesenchymal neoplasms with a high rate of lung metastasis. The cellular mechanisms responsible for sarcoma metastasis remain poorly understood. Furthermore, there are limited efficacious therapeutic strategies for treating metastatic sarcoma. Improved diagnostic and therapeutic modalities are of increasing importance for the treatment of sarcoma due to their high mortality in the advanced stages of the disease. Recent evidence demonstrates that the exosome, a type of extracellular vesicle released by virtually all cells in the body, is an important facilitator of intercellular communication between the cells and the surrounding environment. The exosome is gaining significant attention among the medical research community, but there is little knowledge about how the exosome affects sarcoma metastasis. In this review, we summarize the multifaceted roles of sarcoma-derived exosomes in promoting the process of metastasis via the formation of pre-metastatic niche (PMN), the regulation of immunity, angiogenesis, vascular permeability, and the migration of sarcoma cells. We also highlight the potential of exosomes as innovative diagnostic and prognostic biomarkers as well as therapeutic targets in sarcoma metastasis. MDPI 2023-03-01 /pmc/articles/PMC10046038/ /pubmed/36979391 http://dx.doi.org/10.3390/biom13030456 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tan, Linyun
Wang, Yitian
Hu, Xin
Min, Li
The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets
title The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets
title_full The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets
title_fullStr The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets
title_full_unstemmed The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets
title_short The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets
title_sort roles of exosomes in metastasis of sarcoma: from biomarkers to therapeutic targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046038/
https://www.ncbi.nlm.nih.gov/pubmed/36979391
http://dx.doi.org/10.3390/biom13030456
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