Cargando…

Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters

The aim of this work is to verify the possibility of transport of 26 biologically active ultrashort peptides (USPs) into cells via LAT and PEPT family transporters. Molecular modeling and computer-assisted docking of peptide ligands revealed that the size and structure of ligand-binding sites of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khavinson, Vladimir Khatskelevich, Linkova, Natalia Sergeevna, Rudskoy, Andrey Ivanovich, Petukhov, Michael Gennadievich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046148/ https://www.ncbi.nlm.nih.gov/pubmed/36979488 http://dx.doi.org/10.3390/biom13030552

Ejemplares similares

Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers
por: Khavinson, Vladimir, et al.
Publicado: (2022)

Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer’s Disease
por: Ilina, Anastasiia, et al.
Publicado: (2022)

Peptide Regulation of Gene Expression: A Systematic Review
por: Khavinson, Vladimir Khatskelevich, et al.
Publicado: (2021)

USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2
por: Warsi, Jamshed, et al.
Publicado: (2015)

Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1
por: Foley, David, et al.
Publicado: (2009)

Regulation profile of the intestinal peptide transporter 1 (PepT1)
por: Wang, Chun-Yang, et al.
Publicado: (2017)

Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor
por: Stauffer, Mirko, et al.
Publicado: (2022)

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport
por: Beale, John H., et al.
Publicado: (2015)

Butyrate Transcriptionally Enhances Peptide Transporter PepT1 Expression and Activity
por: Dalmasso, Guillaume, et al.
Publicado: (2008)

Structural basis for oligomerization of the prokaryotic peptide transporter PepT(So2)
por: Nagamura, Reina, et al.
Publicado: (2019)

Systematic search for structural motifs of peptide binding to double-stranded DNA
por: Kolchina, Nina, et al.
Publicado: (2019)

The mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter–channel fence?
por: Meredith, David
Publicado: (2008)

How the Intestinal Peptide Transporter PEPT-1 Contributes to an Obesity Phenotype in Caenorhabditits elegans
por: Spanier, Britta, et al.
Publicado: (2009)

The teleost fish PepT1-type peptide transporters and their relationships with neutral and charged substrates
por: Vacca, Francesca, et al.
Publicado: (2023)

Development and Characterization of a Novel Mouse Line Humanized for the Intestinal Peptide Transporter PEPT1
por: Hu, Yongjun, et al.
Publicado: (2014)

EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease
por: Khavinson, Vladimir, et al.
Publicado: (2020)

Peptides: Prospects for Use in the Treatment of COVID-19
por: Khavinson, Vladimir, et al.
Publicado: (2020)

Peptide Regulation of Chondrogenic Stem Cell Differentiation
por: Linkova, Natalia, et al.
Publicado: (2023)

Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes
por: Killer, Maxime, et al.
Publicado: (2021)

The Reproduction Rate of Peptide Transporter PEPT-1 Deficient C. elegans Is Dependent on Dietary Glutamate Supply
por: Spanier, Britta, et al.
Publicado: (2018)

Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization
por: Wang, Yanhong, et al.
Publicado: (2021)

Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation
por: Khavinson, Vladimir, et al.
Publicado: (2022)

Site-directed mutagenesis of Arginine282 suggests how protons and peptides are co-transported by rabbit PepT1
por: Pieri, Myrtani, et al.
Publicado: (2008)

A Glutathione Peroxidase, Intracellular Peptidases and the TOR Complexes Regulate Peptide Transporter PEPT-1 in C. elegans
por: Benner, Jacqueline, et al.
Publicado: (2011)

Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals
por: Parker, Joanne L., et al.
Publicado: (2021)

The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19
por: Linkova, Natalia, et al.
Publicado: (2023)

Tenapanor administration and the activity of the H(+)‐coupled transporter PepT1 in healthy volunteers
por: Johansson, Susanne, et al.
Publicado: (2017)

Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters
por: Vacca, Francesca, et al.
Publicado: (2022)

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos
por: Gupta, Seema, et al.
Publicado: (2020)

The Intestinal Peptide Transporter PEPT1 Is Involved in Food Intake Regulation in Mice Fed a High-Protein Diet
por: Nässl, Anna-Maria, et al.
Publicado: (2011)

Neuroprotective Effects of Tripeptides—Epigenetic Regulators in Mouse Model of Alzheimer’s Disease
por: Khavinson, Vladimir, et al.
Publicado: (2021)

Rush Hour of LATs towards Their Transport Cycle
por: Nicolàs-Aragó, Adrià, et al.
Publicado: (2021)

Effect of short peptides on neuronal differentiation of stem cells
por: Caputi, Sergio, et al.
Publicado: (2019)

Molecular Insights to the Structure-Interaction Relationships of Human Proton-Coupled Oligopeptide Transporters (PepTs)
por: Luo, Yining, et al.
Publicado: (2023)

Effects of Short-Term Fasting on mRNA Expression of Ghrelin and the Peptide Transporters PepT1 and 2 in Atlantic Salmon (Salmo salar)
por: Del Vecchio, Gianmarco, et al.
Publicado: (2021)

The transmembrane tyrosines Y56, Y91 and Y167 play important roles in determining the affinity and transport rate of the rabbit proton-coupled peptide transporter PepT1
por: Pieri, Myrtani, et al.
Publicado: (2009)

Stabilization of a prokaryotic LAT transporter by random mutagenesis
por: Rodríguez-Banqueri, Arturo, et al.
Publicado: (2016)

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
por: Khavinson, Vladimir, et al.
Publicado: (2020)

Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 Substrates and Inhibitors
por: Kantipudi, Satish, et al.
Publicado: (2021)

Enhanced Absorption and Growth Inhibition with Amino Acid Monoester Prodrugs of Floxuridine by Targeting hPEPT1 Transporters
por: Tsume, Yasuhiro, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_31ogss8e3ae3tl0dokkp4tlgp7