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Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer

SIMPLE SUMMARY: Histological and molecular breast cancer (BC) characteristics are highly important for individualized therapeutical strategies and personalized risk assessment. Despite the improvement of existing image-based staging examinations over the last years, especially the implementation of...

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Autores principales: Jannusch, Kai, Bittner, Ann-Kathrin, Bruckmann, Nils Martin, Morawitz, Janna, Stieglitz, Cleo, Dietzel, Frederic, Quick, Harald H., Baba, Hideo A., Herrmann, Ken, Umutlu, Lale, Antoch, Gerald, Kirchner, Julian, Kasimir-Bauer, Sabine, Hoffmann, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046153/
https://www.ncbi.nlm.nih.gov/pubmed/36980537
http://dx.doi.org/10.3390/cancers15061651
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author Jannusch, Kai
Bittner, Ann-Kathrin
Bruckmann, Nils Martin
Morawitz, Janna
Stieglitz, Cleo
Dietzel, Frederic
Quick, Harald H.
Baba, Hideo A.
Herrmann, Ken
Umutlu, Lale
Antoch, Gerald
Kirchner, Julian
Kasimir-Bauer, Sabine
Hoffmann, Oliver
author_facet Jannusch, Kai
Bittner, Ann-Kathrin
Bruckmann, Nils Martin
Morawitz, Janna
Stieglitz, Cleo
Dietzel, Frederic
Quick, Harald H.
Baba, Hideo A.
Herrmann, Ken
Umutlu, Lale
Antoch, Gerald
Kirchner, Julian
Kasimir-Bauer, Sabine
Hoffmann, Oliver
author_sort Jannusch, Kai
collection PubMed
description SIMPLE SUMMARY: Histological and molecular breast cancer (BC) characteristics are highly important for individualized therapeutical strategies and personalized risk assessment. Despite the improvement of existing image-based staging examinations over the last years, especially the implementation of PET/MRI examinations at leading tumor centers, the invasive part of BC staging is unavoidable. However, the diagnostic potential of PET/MRI has not yet been fully explored. Thus, this study aimed to analyze possible correlations between PET/MRI imaging markers and invasive acquired biomarkers in newly diagnosed early BC to possibly spare invasive procedures for BC patients in the future. At a population of 169 women a correlation between glucose metabolism and estrogen-receptor and progesterone-receptor expression, Ki67, and tumor grading was shown, whereas no correlation regarding disseminated tumor cells (DTCs) could be found. Thus, [(18)F]FDG-PET/MRI may give a first impression of BC-receptor status and BC-tumor biology during initial staging by measuring glucose metabolism but cannot distinguish between DTC-positive/-negative patients and replace biopsy. ABSTRACT: Purpose: Evaluate the diagnostic potential of [(18)F]FDG-PET/MRI data compared with invasive acquired biomarkers in newly diagnosed early breast cancer (BC). Methods: Altogether 169 women with newly diagnosed BC were included. All underwent a breast- and whole-body [(18)F]FDG-PET/MRI for initial staging. A tumor-adapted volume of interest was placed in the primaries and defined bone regions on each standard uptake value (SUV)/apparent diffusion coefficient (ADC) dataset. Immunohistochemical markers, molecular subtype, tumor grading, and disseminated tumor cells (DTCs) of each patient were assessed after ultrasound-guided biopsy of the primaries and bone marrow (BM) aspiration. Correlation analysis and group comparisons were assessed. Results: A significant inverse correlation of estrogen-receptor (ER) expression and progesterone-receptor (PR) expression towards SUV(max) was found (ER: r = 0.27, p < 0.01; PR: r = 0.19, p < 0.05). HER2-receptor expression showed no significant correlation towards SUV and ADC values. A significant positive correlation between Ki67 and SUVmax and SUV(mean) (r = 0.42 p < 0.01; r = 0.19 p < 0.05) was shown. Tumor grading significantly correlated with SUV(max) and SUV(mean) (ρ = 0.36 and ρ = 0.39, both p’s < 0.01). There were no group differences between SUV/ADC values of DTC-positive/-negative patients. Conclusions: [(18)F]FDG-PET/MRI may give a first impression of BC-receptor status and BC-tumor biology during initial staging by measuring glucose metabolism but cannot distinguish between DTC-positive/-negative patients and replace biopsy.
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spelling pubmed-100461532023-03-29 Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer Jannusch, Kai Bittner, Ann-Kathrin Bruckmann, Nils Martin Morawitz, Janna Stieglitz, Cleo Dietzel, Frederic Quick, Harald H. Baba, Hideo A. Herrmann, Ken Umutlu, Lale Antoch, Gerald Kirchner, Julian Kasimir-Bauer, Sabine Hoffmann, Oliver Cancers (Basel) Article SIMPLE SUMMARY: Histological and molecular breast cancer (BC) characteristics are highly important for individualized therapeutical strategies and personalized risk assessment. Despite the improvement of existing image-based staging examinations over the last years, especially the implementation of PET/MRI examinations at leading tumor centers, the invasive part of BC staging is unavoidable. However, the diagnostic potential of PET/MRI has not yet been fully explored. Thus, this study aimed to analyze possible correlations between PET/MRI imaging markers and invasive acquired biomarkers in newly diagnosed early BC to possibly spare invasive procedures for BC patients in the future. At a population of 169 women a correlation between glucose metabolism and estrogen-receptor and progesterone-receptor expression, Ki67, and tumor grading was shown, whereas no correlation regarding disseminated tumor cells (DTCs) could be found. Thus, [(18)F]FDG-PET/MRI may give a first impression of BC-receptor status and BC-tumor biology during initial staging by measuring glucose metabolism but cannot distinguish between DTC-positive/-negative patients and replace biopsy. ABSTRACT: Purpose: Evaluate the diagnostic potential of [(18)F]FDG-PET/MRI data compared with invasive acquired biomarkers in newly diagnosed early breast cancer (BC). Methods: Altogether 169 women with newly diagnosed BC were included. All underwent a breast- and whole-body [(18)F]FDG-PET/MRI for initial staging. A tumor-adapted volume of interest was placed in the primaries and defined bone regions on each standard uptake value (SUV)/apparent diffusion coefficient (ADC) dataset. Immunohistochemical markers, molecular subtype, tumor grading, and disseminated tumor cells (DTCs) of each patient were assessed after ultrasound-guided biopsy of the primaries and bone marrow (BM) aspiration. Correlation analysis and group comparisons were assessed. Results: A significant inverse correlation of estrogen-receptor (ER) expression and progesterone-receptor (PR) expression towards SUV(max) was found (ER: r = 0.27, p < 0.01; PR: r = 0.19, p < 0.05). HER2-receptor expression showed no significant correlation towards SUV and ADC values. A significant positive correlation between Ki67 and SUVmax and SUV(mean) (r = 0.42 p < 0.01; r = 0.19 p < 0.05) was shown. Tumor grading significantly correlated with SUV(max) and SUV(mean) (ρ = 0.36 and ρ = 0.39, both p’s < 0.01). There were no group differences between SUV/ADC values of DTC-positive/-negative patients. Conclusions: [(18)F]FDG-PET/MRI may give a first impression of BC-receptor status and BC-tumor biology during initial staging by measuring glucose metabolism but cannot distinguish between DTC-positive/-negative patients and replace biopsy. MDPI 2023-03-08 /pmc/articles/PMC10046153/ /pubmed/36980537 http://dx.doi.org/10.3390/cancers15061651 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jannusch, Kai
Bittner, Ann-Kathrin
Bruckmann, Nils Martin
Morawitz, Janna
Stieglitz, Cleo
Dietzel, Frederic
Quick, Harald H.
Baba, Hideo A.
Herrmann, Ken
Umutlu, Lale
Antoch, Gerald
Kirchner, Julian
Kasimir-Bauer, Sabine
Hoffmann, Oliver
Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer
title Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer
title_full Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer
title_fullStr Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer
title_full_unstemmed Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer
title_short Correlation between Imaging Markers Derived from PET/MRI and Invasive Acquired Biomarkers in Newly Diagnosed Breast Cancer
title_sort correlation between imaging markers derived from pet/mri and invasive acquired biomarkers in newly diagnosed breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046153/
https://www.ncbi.nlm.nih.gov/pubmed/36980537
http://dx.doi.org/10.3390/cancers15061651
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