Mitochondrial Calcium Nanoregulators Reverse the Macrophage Proinflammatory Phenotype Through Restoring Mitochondrial Calcium Homeostasis for the Treatment of Osteoarthritis

INTRODUCTION: Osteoarthritis (OA) is a chronic degenerative joint disease accompanied by an elevated macrophage proinflammatory phenotype, which is triggered by persistent pathologically elevated calcium ion levels in mitochondria. However, existing pharmacological compounds targeting the inhibition...

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Detalles Bibliográficos
Autores principales: Lei, Xiao, Tan, Guodong, Wang, Yiming, Chen, Li, Cao, Yuan, Si, Bingxin, Zhen, Zhen, Li, Bei, Jin, Yan, Wang, Wei, Jin, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046163/
https://www.ncbi.nlm.nih.gov/pubmed/36998601
http://dx.doi.org/10.2147/IJN.S402170

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