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Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole

Glioblastoma Multiforme (GBM) is a tumor that infiltrates several brain structures. GBM is associated with abnormal motor activities resulting in impaired mobility, producing a loss of functional motor independence. We used a GBM xenograft implanted in the striatum to analyze the changes in Y (verti...

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Autores principales: Aguilar-García, Irene Guadalupe, Jiménez-Estrada, Ismael, Castañeda-Arellano, Rolando, Alpirez, Jonatan, Mendizabal-Ruiz, Gerardo, Dueñas-Jiménez, Judith Marcela, Gutiérrez-Almeida, Coral Estefania, Osuna-Carrasco, Laura Paulina, Ramírez-Abundis, Viviana, Dueñas-Jiménez, Sergio Horacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046174/
https://www.ncbi.nlm.nih.gov/pubmed/36979306
http://dx.doi.org/10.3390/brainsci13030496
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author Aguilar-García, Irene Guadalupe
Jiménez-Estrada, Ismael
Castañeda-Arellano, Rolando
Alpirez, Jonatan
Mendizabal-Ruiz, Gerardo
Dueñas-Jiménez, Judith Marcela
Gutiérrez-Almeida, Coral Estefania
Osuna-Carrasco, Laura Paulina
Ramírez-Abundis, Viviana
Dueñas-Jiménez, Sergio Horacio
author_facet Aguilar-García, Irene Guadalupe
Jiménez-Estrada, Ismael
Castañeda-Arellano, Rolando
Alpirez, Jonatan
Mendizabal-Ruiz, Gerardo
Dueñas-Jiménez, Judith Marcela
Gutiérrez-Almeida, Coral Estefania
Osuna-Carrasco, Laura Paulina
Ramírez-Abundis, Viviana
Dueñas-Jiménez, Sergio Horacio
author_sort Aguilar-García, Irene Guadalupe
collection PubMed
description Glioblastoma Multiforme (GBM) is a tumor that infiltrates several brain structures. GBM is associated with abnormal motor activities resulting in impaired mobility, producing a loss of functional motor independence. We used a GBM xenograft implanted in the striatum to analyze the changes in Y (vertical) and X (horizontal) axis displacement of the metatarsus, ankle, and knee. We analyzed the steps dissimilarity factor between control and GBM mice with and without anastrozole. The body weight of the untreated animals decreased compared to treated mice. Anastrozole reduced the malignant cells and decreased GPR30 and ERα receptor expression. In addition, we observed a partial recovery in metatarsus and knee joint displacement (dissimilarity factor). The vertical axis displacement of the GBM+anastrozole group showed a difference in the right metatarsus, right knee, and left ankle compared to the GBM group. In the horizontal axis displacement of the right metatarsus, ankle, and knee, the GBM+anastrozole group exhibited a difference at the last third of the step cycle compared to the GBM group. Thus, anastrozole partially modified joint displacement. The dissimilarity factor and the vertical and horizontal displacements study will be of interest in GBM patients with locomotion alterations. Hindlimb displacement and gait locomotion analysis could be a valuable methodological tool in experimental and clinical studies to help diagnose locomotive deficits related to GBM.
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spelling pubmed-100461742023-03-29 Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole Aguilar-García, Irene Guadalupe Jiménez-Estrada, Ismael Castañeda-Arellano, Rolando Alpirez, Jonatan Mendizabal-Ruiz, Gerardo Dueñas-Jiménez, Judith Marcela Gutiérrez-Almeida, Coral Estefania Osuna-Carrasco, Laura Paulina Ramírez-Abundis, Viviana Dueñas-Jiménez, Sergio Horacio Brain Sci Article Glioblastoma Multiforme (GBM) is a tumor that infiltrates several brain structures. GBM is associated with abnormal motor activities resulting in impaired mobility, producing a loss of functional motor independence. We used a GBM xenograft implanted in the striatum to analyze the changes in Y (vertical) and X (horizontal) axis displacement of the metatarsus, ankle, and knee. We analyzed the steps dissimilarity factor between control and GBM mice with and without anastrozole. The body weight of the untreated animals decreased compared to treated mice. Anastrozole reduced the malignant cells and decreased GPR30 and ERα receptor expression. In addition, we observed a partial recovery in metatarsus and knee joint displacement (dissimilarity factor). The vertical axis displacement of the GBM+anastrozole group showed a difference in the right metatarsus, right knee, and left ankle compared to the GBM group. In the horizontal axis displacement of the right metatarsus, ankle, and knee, the GBM+anastrozole group exhibited a difference at the last third of the step cycle compared to the GBM group. Thus, anastrozole partially modified joint displacement. The dissimilarity factor and the vertical and horizontal displacements study will be of interest in GBM patients with locomotion alterations. Hindlimb displacement and gait locomotion analysis could be a valuable methodological tool in experimental and clinical studies to help diagnose locomotive deficits related to GBM. MDPI 2023-03-15 /pmc/articles/PMC10046174/ /pubmed/36979306 http://dx.doi.org/10.3390/brainsci13030496 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aguilar-García, Irene Guadalupe
Jiménez-Estrada, Ismael
Castañeda-Arellano, Rolando
Alpirez, Jonatan
Mendizabal-Ruiz, Gerardo
Dueñas-Jiménez, Judith Marcela
Gutiérrez-Almeida, Coral Estefania
Osuna-Carrasco, Laura Paulina
Ramírez-Abundis, Viviana
Dueñas-Jiménez, Sergio Horacio
Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole
title Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole
title_full Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole
title_fullStr Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole
title_full_unstemmed Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole
title_short Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole
title_sort locomotion outcome improvement in mice with glioblastoma multiforme after treatment with anastrozole
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046174/
https://www.ncbi.nlm.nih.gov/pubmed/36979306
http://dx.doi.org/10.3390/brainsci13030496
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