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Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex

A growing body of literature shows there are sex differences in the patterns of brain activity during long-term memory. However, there is a paucity of evidence on sex differences in functional brain connectivity. We previously identified sex differences in the patterns of connections with the hippoc...

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Autores principales: Spets, Dylan S., Slotnick, Scott D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046190/
https://www.ncbi.nlm.nih.gov/pubmed/36979256
http://dx.doi.org/10.3390/brainsci13030446
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author Spets, Dylan S.
Slotnick, Scott D.
author_facet Spets, Dylan S.
Slotnick, Scott D.
author_sort Spets, Dylan S.
collection PubMed
description A growing body of literature shows there are sex differences in the patterns of brain activity during long-term memory. However, there is a paucity of evidence on sex differences in functional brain connectivity. We previously identified sex differences in the patterns of connections with the hippocampus, a medial temporal lobe (MTL) subregion, during spatial long-term memory. The perirhinal/entorhinal cortex, another MTL subregion, plays a critical role in item memory. In the current functional magnetic resonance imaging (fMRI) study, we investigated perirhinal/entorhinal functional connectivity and the role of sex during item memory. During the study phase, abstract shapes were presented to the left or right of fixation. During the test phase, abstract shapes were presented at fixation, and the participants classified each item as previously “old” or “new”. An entorhinal region of interest (ROI) was identified by contrasting item memory hits and misses. This ROI was connected to regions generally associated with visual memory, including the right inferior frontal gyrus (IFG) and visual-processing regions (the bilateral V1, bilateral cuneus, and left lingual gyrus). Males produced greater connectivity than females with the right IFG/insula and the right V1/bilateral cuneus. Broadly, these results contribute to a growing body of literature supporting sex differences in the brain.
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spelling pubmed-100461902023-03-29 Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex Spets, Dylan S. Slotnick, Scott D. Brain Sci Article A growing body of literature shows there are sex differences in the patterns of brain activity during long-term memory. However, there is a paucity of evidence on sex differences in functional brain connectivity. We previously identified sex differences in the patterns of connections with the hippocampus, a medial temporal lobe (MTL) subregion, during spatial long-term memory. The perirhinal/entorhinal cortex, another MTL subregion, plays a critical role in item memory. In the current functional magnetic resonance imaging (fMRI) study, we investigated perirhinal/entorhinal functional connectivity and the role of sex during item memory. During the study phase, abstract shapes were presented to the left or right of fixation. During the test phase, abstract shapes were presented at fixation, and the participants classified each item as previously “old” or “new”. An entorhinal region of interest (ROI) was identified by contrasting item memory hits and misses. This ROI was connected to regions generally associated with visual memory, including the right inferior frontal gyrus (IFG) and visual-processing regions (the bilateral V1, bilateral cuneus, and left lingual gyrus). Males produced greater connectivity than females with the right IFG/insula and the right V1/bilateral cuneus. Broadly, these results contribute to a growing body of literature supporting sex differences in the brain. MDPI 2023-03-04 /pmc/articles/PMC10046190/ /pubmed/36979256 http://dx.doi.org/10.3390/brainsci13030446 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spets, Dylan S.
Slotnick, Scott D.
Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex
title Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex
title_full Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex
title_fullStr Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex
title_full_unstemmed Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex
title_short Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex
title_sort entorhinal cortex functional connectivity during item long-term memory and the role of sex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046190/
https://www.ncbi.nlm.nih.gov/pubmed/36979256
http://dx.doi.org/10.3390/brainsci13030446
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