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G Protein-Dependent Activation of the PKA-Erk1/2 Pathway by the Striatal Dopamine D1/D3 Receptor Heteromer Involves Beta-Arrestin and the Tyrosine Phosphatase Shp-2

The heteromer composed of dopamine D1 and D3 receptors (D1R–D3R) has been defined as a structure able to trigger Erk1/2 and Akt signaling in a G protein-independent, beta-arrestin 1-dependent way that is physiologically expressed in the ventral striatum and is likely involved in the control of locom...

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Detalles Bibliográficos
Autores principales:	Bono, Federica, Tomasoni, Zaira, Mutti, Veronica, Sbrini, Giulia, Kumar, Rajesh, Longhena, Francesca, Fiorentini, Chiara, Missale, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046256/ https://www.ncbi.nlm.nih.gov/pubmed/36979407 http://dx.doi.org/10.3390/biom13030473

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