Cargando…

G Protein-Dependent Activation of the PKA-Erk1/2 Pathway by the Striatal Dopamine D1/D3 Receptor Heteromer Involves Beta-Arrestin and the Tyrosine Phosphatase Shp-2

The heteromer composed of dopamine D1 and D3 receptors (D1R–D3R) has been defined as a structure able to trigger Erk1/2 and Akt signaling in a G protein-independent, beta-arrestin 1-dependent way that is physiologically expressed in the ventral striatum and is likely involved in the control of locom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bono, Federica, Tomasoni, Zaira, Mutti, Veronica, Sbrini, Giulia, Kumar, Rajesh, Longhena, Francesca, Fiorentini, Chiara, Missale, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046256/ https://www.ncbi.nlm.nih.gov/pubmed/36979407 http://dx.doi.org/10.3390/biom13030473

Ejemplares similares

Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway
por: Mutti, Veronica, et al.
Publicado: (2022)

Dopamine D3 Receptor Heteromerization: Implications for Neuroplasticity and Neuroprotection
por: Bono, Federica, et al.
Publicado: (2020)

Δ-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons
por: Hasbi, Ahmed, et al.
Publicado: (2019)

Evidence against dopamine D1/D2 receptor heteromers
por: Frederick, Aliya L., et al.
Publicado: (2015)

Adenosine A(2A)-dopamine D(2) receptor heteromers operate striatal function: impact on Parkinson's disease pharmacotherapeutics
por: Fernández-Dueñas, Víctor, et al.
Publicado: (2018)

The Dopamine D1–D2 Receptor Heteromer in Striatal Medium Spiny Neurons: Evidence for a Third Distinct Neuronal Pathway in Basal Ganglia
por: Perreault, Melissa L., et al.
Publicado: (2011)

A2A-D2 Heteromers on Striatal Astrocytes: Biochemical and Biophysical Evidence
por: Pelassa, Simone, et al.
Publicado: (2019)

Dopaminergic-cholinergic imbalance in movement disorders: a role for the novel striatal dopamine D(2)- muscarinic acetylcholine M(1) receptor heteromer
por: Crans, René A. J., et al.
Publicado: (2020)

Adenosine Receptor Heteromers and their Integrative Role in Striatal Function
por: Ferré, Sergi, et al.
Publicado: (2007)

Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
por: Hasbi, Ahmed, et al.
Publicado: (2011)

Dopamine D(4) receptor, but not the ADHD-associated D(4.7) variant, forms functional heteromers with the dopamine D(2S) receptor in the brain
por: González, Sergio, et al.
Publicado: (2011)

Dopamine D1–D2 Receptor Heteromer in Dual Phenotype GABA/Glutamate-Coexpressing Striatal Medium Spiny Neurons: Regulation of BDNF, GAD67 and VGLUT1/2
por: Perreault, Melissa L., et al.
Publicado: (2012)

Cocaine Inhibits Dopamine D(2) Receptor Signaling via Sigma-1-D(2) Receptor Heteromers
por: Navarro, Gemma, et al.
Publicado: (2013)

Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity
por: Burmeister, Brian T., et al.
Publicado: (2015)

Neurochemical evidence supporting dopamine D1–D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation
por: Rico, Alberto J., et al.
Publicado: (2016)

Roles of Dopamine D(2) Receptor Subregions in Interactions with β-Arrestin2
por: Zhang, Xiaohan, et al.
Publicado: (2016)

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation
por: Donthamsetti, Prashant, et al.
Publicado: (2018)

Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson’s Disease: An In Situ Proximity Ligation Assay Study
por: Longhena, Francesca, et al.
Publicado: (2018)

Expression of Melatonin and Dopamine D(3) Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension
por: Reyes-Resina, Irene, et al.
Publicado: (2020)

Association of genetic ancestry with striatal dopamine D2/D3 receptor availability
por: Wiers, Corinde E., et al.
Publicado: (2017)

Mapping the Interface of a GPCR Dimer: A Structural Model of the A(2A) Adenosine and D(2) Dopamine Receptor Heteromer
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2018)

Mechanisms for the Modulation of Dopamine D(1) Receptor Signaling in Striatal Neurons
por: Nishi, Akinori, et al.
Publicado: (2011)

Striatal dopamine D1 receptor is essential for contextual fear conditioning
por: Ikegami, Masaru, et al.
Publicado: (2014)

Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes
por: Amato, Sarah, et al.
Publicado: (2023)

Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors
por: Toval, Angel, et al.
Publicado: (2021)

Cariprazine exerts antimanic properties and interferes with dopamine D(2) receptor β-arrestin interactions
por: Gao, Yonglin, et al.
Publicado: (2015)

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function
por: Ferré, Sergi, et al.
Publicado: (2011)

Caffeine increases striatal dopamine D(2)/D(3) receptor availability in the human brain
por: Volkow, N D, et al.
Publicado: (2015)

Development of a New Polymeric Nanocarrier Dedicated to Controlled Clozapine Delivery at the Dopamine D(2)-Serotonin 5-HT(1A) Heteromers
por: Łukasiewicz, Sylwia
Publicado: (2021)

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2
por: Burström, Viktor, et al.
Publicado: (2023)

Targeting SHP2 phosphatase in Myeloproliferative Neoplasms
por: Mali, Raghuveer Singh, et al.
Publicado: (2012)

Ubiquitination of GRK2 Is Required for the β-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases
por: Liu, Haiping, et al.
Publicado: (2023)

Induced pluripotent stem cells for defining Parkinsonian patient subtypes: a further step toward precision medicine
por: Bono, Federica, et al.
Publicado: (2021)

Striatal Dopamine D(2/3) Receptor Availability in Treatment Resistant Depression
por: de Kwaasteniet, Bart P., et al.
Publicado: (2014)

Neuroprotection afforded by targeting G protein-coupled receptors in heteromers and by heteromer-selective drugs
por: Franco, Rafael, et al.
Publicado: (2023)

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor
por: Gray, David L., et al.
Publicado: (2018)

Segregation of D1 and D2 dopamine receptors in the striatal direct and indirect pathways: An historical perspective
por: Gerfen, Charles R.
Publicado: (2023)

Inhibition of SHP2 and SHP1 Protein Tyrosine Phosphatase Activity by Chemically Induced Dimerization
por: Buck, Sara J. S., et al.
Publicado: (2022)

Effects of the Dopamine D2 Allosteric Modulator, PAOPA, on the Expression of GRK2, Arrestin-3, ERK1/2, and on Receptor Internalization
por: Basu, Dipannita, et al.
Publicado: (2013)

Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase
por: Zeng, Li-Fan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_46p1nfq4jknlegm9entv76hp6c