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Interleukin-18 and Gelsolin Are Associated with Acute Kidney Disease after Cardiac Catheterization
Patients undergoing cardiac catheterization are at high risk of post-procedure acute kidney injury (AKI) and may experience persistent renal damage after an initial insult, a state known as acute kidney disease (AKD). However, the association between AKD and urinary renal biomarkers has not yet been...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046301/ https://www.ncbi.nlm.nih.gov/pubmed/36979422 http://dx.doi.org/10.3390/biom13030487 |
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author | Kuo, Po-Yen Tsai, Kai-Fan Wu, Po-Jung Hsu, Pai-Chin Wu, Chien-Hsing Lee, Wen-Chin Fang, Hsiu-Yu Fang, Chih-Yuan Chung, Sheng-Ying Chen, Yung-Lung Chiou, Terry Ting-Yu |
author_facet | Kuo, Po-Yen Tsai, Kai-Fan Wu, Po-Jung Hsu, Pai-Chin Wu, Chien-Hsing Lee, Wen-Chin Fang, Hsiu-Yu Fang, Chih-Yuan Chung, Sheng-Ying Chen, Yung-Lung Chiou, Terry Ting-Yu |
author_sort | Kuo, Po-Yen |
collection | PubMed |
description | Patients undergoing cardiac catheterization are at high risk of post-procedure acute kidney injury (AKI) and may experience persistent renal damage after an initial insult, a state known as acute kidney disease (AKD). However, the association between AKD and urinary renal biomarkers has not yet been evaluated in this population. We enrolled 94 patients who underwent elective cardiac catheterization to investigate patterns of urinary renal biomarkers and their associations with post-procedure AKD. Serial urinary renal biomarker levels were measured during pre-procedure, early post-procedure (12–24 h), and late post-procedure (7–10 days) periods. In our investigation, 42.55% of the enrolled patients developed AKD during the late post-procedure period. While the liver-type free-fatty-acid-binding protein level increased sharply during the early post-procedure period, it returned to baseline during the late post-procedure period. In contrast, interleukin-18 (IL-18) levels increased steadily during the post-procedure period. Early post-procedure ratios of IL-18 and gelsolin (GSN) were independently associated with subsequent AKD (odds ratio (95% confidence interval), 4.742 (1.523–14.759) for IL-18 ratio, p = 0.007; 1.812 (1.027–3.198) for GSN ratio, p = 0.040). In conclusion, post-procedure AKD is common and associated with early changes in urinary IL-18 and GSN in patients undergoing cardiac catheterization. |
format | Online Article Text |
id | pubmed-10046301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100463012023-03-29 Interleukin-18 and Gelsolin Are Associated with Acute Kidney Disease after Cardiac Catheterization Kuo, Po-Yen Tsai, Kai-Fan Wu, Po-Jung Hsu, Pai-Chin Wu, Chien-Hsing Lee, Wen-Chin Fang, Hsiu-Yu Fang, Chih-Yuan Chung, Sheng-Ying Chen, Yung-Lung Chiou, Terry Ting-Yu Biomolecules Article Patients undergoing cardiac catheterization are at high risk of post-procedure acute kidney injury (AKI) and may experience persistent renal damage after an initial insult, a state known as acute kidney disease (AKD). However, the association between AKD and urinary renal biomarkers has not yet been evaluated in this population. We enrolled 94 patients who underwent elective cardiac catheterization to investigate patterns of urinary renal biomarkers and their associations with post-procedure AKD. Serial urinary renal biomarker levels were measured during pre-procedure, early post-procedure (12–24 h), and late post-procedure (7–10 days) periods. In our investigation, 42.55% of the enrolled patients developed AKD during the late post-procedure period. While the liver-type free-fatty-acid-binding protein level increased sharply during the early post-procedure period, it returned to baseline during the late post-procedure period. In contrast, interleukin-18 (IL-18) levels increased steadily during the post-procedure period. Early post-procedure ratios of IL-18 and gelsolin (GSN) were independently associated with subsequent AKD (odds ratio (95% confidence interval), 4.742 (1.523–14.759) for IL-18 ratio, p = 0.007; 1.812 (1.027–3.198) for GSN ratio, p = 0.040). In conclusion, post-procedure AKD is common and associated with early changes in urinary IL-18 and GSN in patients undergoing cardiac catheterization. MDPI 2023-03-06 /pmc/articles/PMC10046301/ /pubmed/36979422 http://dx.doi.org/10.3390/biom13030487 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kuo, Po-Yen Tsai, Kai-Fan Wu, Po-Jung Hsu, Pai-Chin Wu, Chien-Hsing Lee, Wen-Chin Fang, Hsiu-Yu Fang, Chih-Yuan Chung, Sheng-Ying Chen, Yung-Lung Chiou, Terry Ting-Yu Interleukin-18 and Gelsolin Are Associated with Acute Kidney Disease after Cardiac Catheterization |
title | Interleukin-18 and Gelsolin Are Associated with Acute Kidney Disease after Cardiac Catheterization |
title_full | Interleukin-18 and Gelsolin Are Associated with Acute Kidney Disease after Cardiac Catheterization |
title_fullStr | Interleukin-18 and Gelsolin Are Associated with Acute Kidney Disease after Cardiac Catheterization |
title_full_unstemmed | Interleukin-18 and Gelsolin Are Associated with Acute Kidney Disease after Cardiac Catheterization |
title_short | Interleukin-18 and Gelsolin Are Associated with Acute Kidney Disease after Cardiac Catheterization |
title_sort | interleukin-18 and gelsolin are associated with acute kidney disease after cardiac catheterization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046301/ https://www.ncbi.nlm.nih.gov/pubmed/36979422 http://dx.doi.org/10.3390/biom13030487 |
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