The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study

Increased activity in the left inferior parietal cortex (BA40) plays a role in the generation of tics in the Gilles de la Tourette syndrome (GTS). Thus, inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to BA40 was hypothesized to alleviate symptoms in GTS. We investigated the i...

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Autores principales: Paulus, Theresa, Wernecke, Lynn, Lundie, Annik, Friedrich, Julia, Verrel, Julius, Rawish, Tina, Weissbach, Anne, Frings, Christian, Beste, Christian, Bäumer, Tobias, Münchau, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046361/
https://www.ncbi.nlm.nih.gov/pubmed/36979959
http://dx.doi.org/10.3390/biomedicines11030980
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author Paulus, Theresa
Wernecke, Lynn
Lundie, Annik
Friedrich, Julia
Verrel, Julius
Rawish, Tina
Weissbach, Anne
Frings, Christian
Beste, Christian
Bäumer, Tobias
Münchau, Alexander
author_facet Paulus, Theresa
Wernecke, Lynn
Lundie, Annik
Friedrich, Julia
Verrel, Julius
Rawish, Tina
Weissbach, Anne
Frings, Christian
Beste, Christian
Bäumer, Tobias
Münchau, Alexander
author_sort Paulus, Theresa
collection PubMed
description Increased activity in the left inferior parietal cortex (BA40) plays a role in the generation of tics in the Gilles de la Tourette syndrome (GTS). Thus, inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to BA40 was hypothesized to alleviate symptoms in GTS. We investigated the immediate effects of single-session 1 Hz rTMS and sham stimulation delivered to the left BA40 on tics assessed with the Rush video protocol in 29 adults with GTS. There were no significant effects on tic symptoms following rTMS or sham stimulation. Moreover, there was no difference when comparing the effects of both stimulation conditions. Bayesian statistics indicated substantial evidence against an intervention effect. The left BA40 appears not to be a useful target for 1 Hz rTMS to modulate tic symptoms in GTS patients.
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spelling pubmed-100463612023-03-29 The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study Paulus, Theresa Wernecke, Lynn Lundie, Annik Friedrich, Julia Verrel, Julius Rawish, Tina Weissbach, Anne Frings, Christian Beste, Christian Bäumer, Tobias Münchau, Alexander Biomedicines Brief Report Increased activity in the left inferior parietal cortex (BA40) plays a role in the generation of tics in the Gilles de la Tourette syndrome (GTS). Thus, inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to BA40 was hypothesized to alleviate symptoms in GTS. We investigated the immediate effects of single-session 1 Hz rTMS and sham stimulation delivered to the left BA40 on tics assessed with the Rush video protocol in 29 adults with GTS. There were no significant effects on tic symptoms following rTMS or sham stimulation. Moreover, there was no difference when comparing the effects of both stimulation conditions. Bayesian statistics indicated substantial evidence against an intervention effect. The left BA40 appears not to be a useful target for 1 Hz rTMS to modulate tic symptoms in GTS patients. MDPI 2023-03-22 /pmc/articles/PMC10046361/ /pubmed/36979959 http://dx.doi.org/10.3390/biomedicines11030980 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Paulus, Theresa
Wernecke, Lynn
Lundie, Annik
Friedrich, Julia
Verrel, Julius
Rawish, Tina
Weissbach, Anne
Frings, Christian
Beste, Christian
Bäumer, Tobias
Münchau, Alexander
The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study
title The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study
title_full The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study
title_fullStr The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study
title_full_unstemmed The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study
title_short The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study
title_sort role of the left inferior parietal cortex in gilles de la tourette syndrome—an rtms study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046361/
https://www.ncbi.nlm.nih.gov/pubmed/36979959
http://dx.doi.org/10.3390/biomedicines11030980
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