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Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study

Background: Attention-deficit–hyperactivity disorder (ADHD) is a neurodevelopmental disorder neurobiologically conceptualized as a network disorder in white and gray matter. A relatively new branch in ADHD research is sensory processing. Here, altered sensory processing i.e., sensory hypersensitivit...

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Autores principales: Schulze, Marcel, Aslan, Behrem, Farrher, Ezequiel, Grinberg, Farida, Shah, Nadim, Schirmer, Markus, Radbruch, Alexander, Stöcker, Tony, Lux, Silke, Philipsen, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046412/
https://www.ncbi.nlm.nih.gov/pubmed/36979198
http://dx.doi.org/10.3390/brainsci13030388
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author Schulze, Marcel
Aslan, Behrem
Farrher, Ezequiel
Grinberg, Farida
Shah, Nadim
Schirmer, Markus
Radbruch, Alexander
Stöcker, Tony
Lux, Silke
Philipsen, Alexandra
author_facet Schulze, Marcel
Aslan, Behrem
Farrher, Ezequiel
Grinberg, Farida
Shah, Nadim
Schirmer, Markus
Radbruch, Alexander
Stöcker, Tony
Lux, Silke
Philipsen, Alexandra
author_sort Schulze, Marcel
collection PubMed
description Background: Attention-deficit–hyperactivity disorder (ADHD) is a neurodevelopmental disorder neurobiologically conceptualized as a network disorder in white and gray matter. A relatively new branch in ADHD research is sensory processing. Here, altered sensory processing i.e., sensory hypersensitivity, is reported, especially in the auditory domain. However, our perception is driven by a complex interplay across different sensory modalities. Our brain is specialized in binding those different sensory modalities to a unified percept—a process called multisensory integration (MI) that is mediated through fronto-temporal and fronto-parietal networks. MI has been recently described to be impaired for complex stimuli in adult patients with ADHD. The current study relates MI in adult ADHD with diffusion-weighted imaging. Connectome-based and graph-theoretic analysis was applied to investigate a possible relationship between the ability to integrate multimodal input and network-based ADHD pathophysiology. Methods: Multishell, high-angular resolution diffusion-weighted imaging was performed on twenty-five patients with ADHD (six females, age: 30.08 (SD: 9.3) years) and twenty-four healthy controls (nine females; age: 26.88 (SD: 6.3) years). Structural connectome was created and graph theory was applied to investigate ADHD pathophysiology. Additionally, MI scores, i.e., the percentage of successful multisensory integration derived from the McGurk paradigm, were groupwise correlated with the structural connectome. Results: Structural connectivity was elevated in patients with ADHD in network hubs mirroring altered default-mode network activity typically reported for patients with ADHD. Compared to controls, MI was associated with higher connectivity in ADHD between Heschl’s gyrus and auditory parabelt regions along with altered fronto-temporal network integrity. Conclusion: Alterations in structural network integrity in adult ADHD can be extended to multisensory behavior. MI and the respective network integration in ADHD might represent the maturational cortical delay that extends to adulthood with respect to sensory processing.
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spelling pubmed-100464122023-03-29 Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study Schulze, Marcel Aslan, Behrem Farrher, Ezequiel Grinberg, Farida Shah, Nadim Schirmer, Markus Radbruch, Alexander Stöcker, Tony Lux, Silke Philipsen, Alexandra Brain Sci Article Background: Attention-deficit–hyperactivity disorder (ADHD) is a neurodevelopmental disorder neurobiologically conceptualized as a network disorder in white and gray matter. A relatively new branch in ADHD research is sensory processing. Here, altered sensory processing i.e., sensory hypersensitivity, is reported, especially in the auditory domain. However, our perception is driven by a complex interplay across different sensory modalities. Our brain is specialized in binding those different sensory modalities to a unified percept—a process called multisensory integration (MI) that is mediated through fronto-temporal and fronto-parietal networks. MI has been recently described to be impaired for complex stimuli in adult patients with ADHD. The current study relates MI in adult ADHD with diffusion-weighted imaging. Connectome-based and graph-theoretic analysis was applied to investigate a possible relationship between the ability to integrate multimodal input and network-based ADHD pathophysiology. Methods: Multishell, high-angular resolution diffusion-weighted imaging was performed on twenty-five patients with ADHD (six females, age: 30.08 (SD: 9.3) years) and twenty-four healthy controls (nine females; age: 26.88 (SD: 6.3) years). Structural connectome was created and graph theory was applied to investigate ADHD pathophysiology. Additionally, MI scores, i.e., the percentage of successful multisensory integration derived from the McGurk paradigm, were groupwise correlated with the structural connectome. Results: Structural connectivity was elevated in patients with ADHD in network hubs mirroring altered default-mode network activity typically reported for patients with ADHD. Compared to controls, MI was associated with higher connectivity in ADHD between Heschl’s gyrus and auditory parabelt regions along with altered fronto-temporal network integrity. Conclusion: Alterations in structural network integrity in adult ADHD can be extended to multisensory behavior. MI and the respective network integration in ADHD might represent the maturational cortical delay that extends to adulthood with respect to sensory processing. MDPI 2023-02-23 /pmc/articles/PMC10046412/ /pubmed/36979198 http://dx.doi.org/10.3390/brainsci13030388 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schulze, Marcel
Aslan, Behrem
Farrher, Ezequiel
Grinberg, Farida
Shah, Nadim
Schirmer, Markus
Radbruch, Alexander
Stöcker, Tony
Lux, Silke
Philipsen, Alexandra
Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study
title Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study
title_full Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study
title_fullStr Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study
title_full_unstemmed Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study
title_short Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study
title_sort network-based differences in top–down multisensory integration between adult adhd and healthy controls—a diffusion mri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046412/
https://www.ncbi.nlm.nih.gov/pubmed/36979198
http://dx.doi.org/10.3390/brainsci13030388
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