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TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD

The inflammatory pathway driven by TNF-α, through its receptors TNFR1 and TNFR2, is a common feature in the pathogenesis of chronic kidney disease (CKD), regardless of the initial disease cause. Evidence correlates the chronic inflammatory status with decreased renal function. Our aim was to evaluat...

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Autores principales: Lousa, Irina, Reis, Flávio, Viana, Sofia, Vieira, Pedro, Vala, Helena, Belo, Luís, Santos-Silva, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046457/
https://www.ncbi.nlm.nih.gov/pubmed/36979469
http://dx.doi.org/10.3390/biom13030534
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author Lousa, Irina
Reis, Flávio
Viana, Sofia
Vieira, Pedro
Vala, Helena
Belo, Luís
Santos-Silva, Alice
author_facet Lousa, Irina
Reis, Flávio
Viana, Sofia
Vieira, Pedro
Vala, Helena
Belo, Luís
Santos-Silva, Alice
author_sort Lousa, Irina
collection PubMed
description The inflammatory pathway driven by TNF-α, through its receptors TNFR1 and TNFR2, is a common feature in the pathogenesis of chronic kidney disease (CKD), regardless of the initial disease cause. Evidence correlates the chronic inflammatory status with decreased renal function. Our aim was to evaluate the potential of TNF receptors as biomarkers for CKD diagnosis and staging, as well as their association with the progression of renal lesions, in rat models of early and moderate CKD. We analyzed the circulating levels of inflammatory molecules—tumor necrosis factor-alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1) and 2 (TNFR2) and tissue inhibitor of metalloproteinase-1 (TIMP-1)—and studied their associations with TNFR1 and TNFR2 renal expression, glomerular and tubulointerstitial lesions, and with biomarkers of renal (dys)function. An increase in all inflammatory markers was observed in moderate CKD, as compared to controls, but only circulating levels of both TNFR1 and TNFR2 were significantly increased in the early disease; TNFR2 serum levels were negatively correlated with eGFR. However, only TNFR2 renal expression increased with CKD severity and showed correlations with the score of mild and advanced tubular lesions. Our findings suggest that renal TNFR2 plays a role in CKD development, and has potential to be used as a biomarker for the early detection and progression of the disease. Still, the potential value of this biomarker in disease progression warrants further investigation.
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spelling pubmed-100464572023-03-29 TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD Lousa, Irina Reis, Flávio Viana, Sofia Vieira, Pedro Vala, Helena Belo, Luís Santos-Silva, Alice Biomolecules Article The inflammatory pathway driven by TNF-α, through its receptors TNFR1 and TNFR2, is a common feature in the pathogenesis of chronic kidney disease (CKD), regardless of the initial disease cause. Evidence correlates the chronic inflammatory status with decreased renal function. Our aim was to evaluate the potential of TNF receptors as biomarkers for CKD diagnosis and staging, as well as their association with the progression of renal lesions, in rat models of early and moderate CKD. We analyzed the circulating levels of inflammatory molecules—tumor necrosis factor-alpha (TNF-α), tumor necrosis factor receptor 1 (TNFR1) and 2 (TNFR2) and tissue inhibitor of metalloproteinase-1 (TIMP-1)—and studied their associations with TNFR1 and TNFR2 renal expression, glomerular and tubulointerstitial lesions, and with biomarkers of renal (dys)function. An increase in all inflammatory markers was observed in moderate CKD, as compared to controls, but only circulating levels of both TNFR1 and TNFR2 were significantly increased in the early disease; TNFR2 serum levels were negatively correlated with eGFR. However, only TNFR2 renal expression increased with CKD severity and showed correlations with the score of mild and advanced tubular lesions. Our findings suggest that renal TNFR2 plays a role in CKD development, and has potential to be used as a biomarker for the early detection and progression of the disease. Still, the potential value of this biomarker in disease progression warrants further investigation. MDPI 2023-03-15 /pmc/articles/PMC10046457/ /pubmed/36979469 http://dx.doi.org/10.3390/biom13030534 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lousa, Irina
Reis, Flávio
Viana, Sofia
Vieira, Pedro
Vala, Helena
Belo, Luís
Santos-Silva, Alice
TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
title TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
title_full TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
title_fullStr TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
title_full_unstemmed TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
title_short TNFR2 as a Potential Biomarker for Early Detection and Progression of CKD
title_sort tnfr2 as a potential biomarker for early detection and progression of ckd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046457/
https://www.ncbi.nlm.nih.gov/pubmed/36979469
http://dx.doi.org/10.3390/biom13030534
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