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COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review

There is an increased incidence of elderly adults diagnosed with kidney failure as our global aging population continues to expand. Hence, the number of elderly adults indicated for kidney replacement therapy is also increasing simultaneously. Haemodialysis initiation is more commonly observed in co...

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Autores principales: McDonnell, Thomas, Wu, Henry H. L., Kalra, Philip A., Chinnadurai, Rajkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046485/
https://www.ncbi.nlm.nih.gov/pubmed/36979905
http://dx.doi.org/10.3390/biomedicines11030926
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author McDonnell, Thomas
Wu, Henry H. L.
Kalra, Philip A.
Chinnadurai, Rajkumar
author_facet McDonnell, Thomas
Wu, Henry H. L.
Kalra, Philip A.
Chinnadurai, Rajkumar
author_sort McDonnell, Thomas
collection PubMed
description There is an increased incidence of elderly adults diagnosed with kidney failure as our global aging population continues to expand. Hence, the number of elderly adults indicated for kidney replacement therapy is also increasing simultaneously. Haemodialysis initiation is more commonly observed in comparison to kidney transplantation and peritoneal dialysis for the elderly. The onset of the coronavirus 2019 (COVID-19) pandemic brought new paradigms and insights for the care of this patient population. Elderly patients receiving haemodialysis have been identified as high-risk groups for poor COVID-19 outcomes. Age, immunosenescence, impaired response to COVID-19 vaccination, increased exposure to sources of COVID-19 infection and thrombotic risks during dialysis are key factors which demonstrated significant associations with COVID-19 incidence, severity and mortality for this patient group. Recent findings suggest that preventative measures such as regular screening and, if needed, isolation in COVID-19-positive cases, alongside the fulfillment of COVID-19 vaccination programs is an integral strategy to reduce the number of COVID-19 cases and consequential complications from COVID-19, particularly for high-risk groups such as elderly haemodialysis patients. The COVID-19 pandemic brought about the rapid development and repurposing of a number of medications to treat patients in the viral and inflammatory stages of their disease. However, elderly haemodialysis patients were grossly unrepresented in many of these trials. We review the evidence for contemporary treatments for COVID-19 in this population to provide clinicians with an up-to-date guide. We hope our article increases awareness on the associations and impact of COVID-19 for the elderly haemodialysis population, and encourage research efforts to address knowledge gaps in this topical area.
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spelling pubmed-100464852023-03-29 COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review McDonnell, Thomas Wu, Henry H. L. Kalra, Philip A. Chinnadurai, Rajkumar Biomedicines Review There is an increased incidence of elderly adults diagnosed with kidney failure as our global aging population continues to expand. Hence, the number of elderly adults indicated for kidney replacement therapy is also increasing simultaneously. Haemodialysis initiation is more commonly observed in comparison to kidney transplantation and peritoneal dialysis for the elderly. The onset of the coronavirus 2019 (COVID-19) pandemic brought new paradigms and insights for the care of this patient population. Elderly patients receiving haemodialysis have been identified as high-risk groups for poor COVID-19 outcomes. Age, immunosenescence, impaired response to COVID-19 vaccination, increased exposure to sources of COVID-19 infection and thrombotic risks during dialysis are key factors which demonstrated significant associations with COVID-19 incidence, severity and mortality for this patient group. Recent findings suggest that preventative measures such as regular screening and, if needed, isolation in COVID-19-positive cases, alongside the fulfillment of COVID-19 vaccination programs is an integral strategy to reduce the number of COVID-19 cases and consequential complications from COVID-19, particularly for high-risk groups such as elderly haemodialysis patients. The COVID-19 pandemic brought about the rapid development and repurposing of a number of medications to treat patients in the viral and inflammatory stages of their disease. However, elderly haemodialysis patients were grossly unrepresented in many of these trials. We review the evidence for contemporary treatments for COVID-19 in this population to provide clinicians with an up-to-date guide. We hope our article increases awareness on the associations and impact of COVID-19 for the elderly haemodialysis population, and encourage research efforts to address knowledge gaps in this topical area. MDPI 2023-03-16 /pmc/articles/PMC10046485/ /pubmed/36979905 http://dx.doi.org/10.3390/biomedicines11030926 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
McDonnell, Thomas
Wu, Henry H. L.
Kalra, Philip A.
Chinnadurai, Rajkumar
COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review
title COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review
title_full COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review
title_fullStr COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review
title_full_unstemmed COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review
title_short COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review
title_sort covid-19 in elderly patients receiving haemodialysis: a current review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046485/
https://www.ncbi.nlm.nih.gov/pubmed/36979905
http://dx.doi.org/10.3390/biomedicines11030926
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