Cargando…

An Electrolyte-Gated Graphene Field-Effect Transistor for Detection of Gadolinium(III) in Aqueous Media

In this work, an electrolyte-gated graphene field-effect transistor is developed for Gd(3+) ion detection in water. The source and drain electrodes of the transistor are fabricated by photolithography on polyimide, while the graphene channel is obtained by inkjet-printing a graphene oxide ink subseq...

Descripción completa

Detalles Bibliográficos
Autores principales: Gadroy, Charlène, Boukraa, Rassen, Battaglini, Nicolas, Le Derf, Franck, Mofaddel, Nadine, Vieillard, Julien, Piro, Benoît
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046572/
https://www.ncbi.nlm.nih.gov/pubmed/36979575
http://dx.doi.org/10.3390/bios13030363
_version_ 1785013706836410368
author Gadroy, Charlène
Boukraa, Rassen
Battaglini, Nicolas
Le Derf, Franck
Mofaddel, Nadine
Vieillard, Julien
Piro, Benoît
author_facet Gadroy, Charlène
Boukraa, Rassen
Battaglini, Nicolas
Le Derf, Franck
Mofaddel, Nadine
Vieillard, Julien
Piro, Benoît
author_sort Gadroy, Charlène
collection PubMed
description In this work, an electrolyte-gated graphene field-effect transistor is developed for Gd(3+) ion detection in water. The source and drain electrodes of the transistor are fabricated by photolithography on polyimide, while the graphene channel is obtained by inkjet-printing a graphene oxide ink subsequently electro-reduced to give reduced graphene oxide. The Gd(3+)-selective ligand DOTA is functionalized by an alkyne linker to be grafted by click chemistry on a gold electrode without losing its affinity for Gd(3+). The synthesis route is fully described, and the ligand, the linker and the functionalized surface are characterized by electrochemical analysis and spectroscopy. The as functionalized electrode is used as gate in the graphene transistor so to modulate the source-drain current as a function of its potential, which is itself modulated by the concentration of Gd(3+)captured on the gate surface. The obtained sensor is able to quantify Gd(3+) even in a sample containing several other potentially interfering ions such as Ni(2+), Ca(2+), Na(+) and In(3+). The quantification range is from 1 pM to 10 mM, with a sensitivity of 20 mV dec(−1) expected for a trivalent ion. This paves the way for Gd(3+) quantification in hospital or industrial wastewater.
format Online
Article
Text
id pubmed-10046572
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100465722023-03-29 An Electrolyte-Gated Graphene Field-Effect Transistor for Detection of Gadolinium(III) in Aqueous Media Gadroy, Charlène Boukraa, Rassen Battaglini, Nicolas Le Derf, Franck Mofaddel, Nadine Vieillard, Julien Piro, Benoît Biosensors (Basel) Article In this work, an electrolyte-gated graphene field-effect transistor is developed for Gd(3+) ion detection in water. The source and drain electrodes of the transistor are fabricated by photolithography on polyimide, while the graphene channel is obtained by inkjet-printing a graphene oxide ink subsequently electro-reduced to give reduced graphene oxide. The Gd(3+)-selective ligand DOTA is functionalized by an alkyne linker to be grafted by click chemistry on a gold electrode without losing its affinity for Gd(3+). The synthesis route is fully described, and the ligand, the linker and the functionalized surface are characterized by electrochemical analysis and spectroscopy. The as functionalized electrode is used as gate in the graphene transistor so to modulate the source-drain current as a function of its potential, which is itself modulated by the concentration of Gd(3+)captured on the gate surface. The obtained sensor is able to quantify Gd(3+) even in a sample containing several other potentially interfering ions such as Ni(2+), Ca(2+), Na(+) and In(3+). The quantification range is from 1 pM to 10 mM, with a sensitivity of 20 mV dec(−1) expected for a trivalent ion. This paves the way for Gd(3+) quantification in hospital or industrial wastewater. MDPI 2023-03-09 /pmc/articles/PMC10046572/ /pubmed/36979575 http://dx.doi.org/10.3390/bios13030363 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gadroy, Charlène
Boukraa, Rassen
Battaglini, Nicolas
Le Derf, Franck
Mofaddel, Nadine
Vieillard, Julien
Piro, Benoît
An Electrolyte-Gated Graphene Field-Effect Transistor for Detection of Gadolinium(III) in Aqueous Media
title An Electrolyte-Gated Graphene Field-Effect Transistor for Detection of Gadolinium(III) in Aqueous Media
title_full An Electrolyte-Gated Graphene Field-Effect Transistor for Detection of Gadolinium(III) in Aqueous Media
title_fullStr An Electrolyte-Gated Graphene Field-Effect Transistor for Detection of Gadolinium(III) in Aqueous Media
title_full_unstemmed An Electrolyte-Gated Graphene Field-Effect Transistor for Detection of Gadolinium(III) in Aqueous Media
title_short An Electrolyte-Gated Graphene Field-Effect Transistor for Detection of Gadolinium(III) in Aqueous Media
title_sort electrolyte-gated graphene field-effect transistor for detection of gadolinium(iii) in aqueous media
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046572/
https://www.ncbi.nlm.nih.gov/pubmed/36979575
http://dx.doi.org/10.3390/bios13030363
work_keys_str_mv AT gadroycharlene anelectrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT boukraarassen anelectrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT battaglininicolas anelectrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT lederffranck anelectrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT mofaddelnadine anelectrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT vieillardjulien anelectrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT pirobenoit anelectrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT gadroycharlene electrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT boukraarassen electrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT battaglininicolas electrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT lederffranck electrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT mofaddelnadine electrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT vieillardjulien electrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia
AT pirobenoit electrolytegatedgraphenefieldeffecttransistorfordetectionofgadoliniumiiiinaqueousmedia