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Association between Systemic Immune Inflammation Index and Cognitive Impairment after Acute Ischemic Stroke

Background and Aims: Post-stroke cognitive impairment (PSCI) is one of the major complications after ischemic stroke. PSCI has been shown to be associated with low-grade systemic inflammation. As a novel inflammatory marker, the systemic immune-inflammation (SII) index could reflect clinical outcome...

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Autores principales: Bao, Yuanfei, Wang, Lingling, Du, Chaopin, Ji, Yan, Dai, Yiwei, Jiang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046597/
https://www.ncbi.nlm.nih.gov/pubmed/36979274
http://dx.doi.org/10.3390/brainsci13030464
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author Bao, Yuanfei
Wang, Lingling
Du, Chaopin
Ji, Yan
Dai, Yiwei
Jiang, Wei
author_facet Bao, Yuanfei
Wang, Lingling
Du, Chaopin
Ji, Yan
Dai, Yiwei
Jiang, Wei
author_sort Bao, Yuanfei
collection PubMed
description Background and Aims: Post-stroke cognitive impairment (PSCI) is one of the major complications after ischemic stroke. PSCI has been shown to be associated with low-grade systemic inflammation. As a novel inflammatory marker, the systemic immune-inflammation (SII) index could reflect clinical outcomes in severe cardiovascular diseases. We therefore performed a prospective study to investigate the correlation between the SII index and the risk of PSCI in patients with ischemic stroke. Methods: We prospectively enrolled 254 patients with ischemic stroke with symptoms onset <72 h. The SII index was detected within 24 h after admission. The Montreal Cognitive Scale (MoCA) was utilized to evaluate cognitive function, and PSCI was defined as a MoCA score of <25 points. Results: During the 3-month follow-up, 70 participants (27.6%) had mild cognitive impairment and 60 (23.6%) had severe cognitive impairment. In binary logistic regression analysis, each one-standard deviation increase in the SII index was significantly associated with the prevalence of PSCI after adjusting for age, sex, and other confounders (odds ratio 2.341; 95% confidence interval, 1.439–3.809, p = 0.001). Similar significant findings were observed when SII was defined as a categorical variable. In addition, the multiple-adjusted spline regression model showed a linear association between the SII index and cognitive impairment (p = 0.003 for linearity). Conclusions: Our study indicated that an increased SII index was closely related to PSCI at 3 months in patients with ischemic stroke. Further research is required to evaluate the efficacy of inflammation management in these patients.
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spelling pubmed-100465972023-03-29 Association between Systemic Immune Inflammation Index and Cognitive Impairment after Acute Ischemic Stroke Bao, Yuanfei Wang, Lingling Du, Chaopin Ji, Yan Dai, Yiwei Jiang, Wei Brain Sci Article Background and Aims: Post-stroke cognitive impairment (PSCI) is one of the major complications after ischemic stroke. PSCI has been shown to be associated with low-grade systemic inflammation. As a novel inflammatory marker, the systemic immune-inflammation (SII) index could reflect clinical outcomes in severe cardiovascular diseases. We therefore performed a prospective study to investigate the correlation between the SII index and the risk of PSCI in patients with ischemic stroke. Methods: We prospectively enrolled 254 patients with ischemic stroke with symptoms onset <72 h. The SII index was detected within 24 h after admission. The Montreal Cognitive Scale (MoCA) was utilized to evaluate cognitive function, and PSCI was defined as a MoCA score of <25 points. Results: During the 3-month follow-up, 70 participants (27.6%) had mild cognitive impairment and 60 (23.6%) had severe cognitive impairment. In binary logistic regression analysis, each one-standard deviation increase in the SII index was significantly associated with the prevalence of PSCI after adjusting for age, sex, and other confounders (odds ratio 2.341; 95% confidence interval, 1.439–3.809, p = 0.001). Similar significant findings were observed when SII was defined as a categorical variable. In addition, the multiple-adjusted spline regression model showed a linear association between the SII index and cognitive impairment (p = 0.003 for linearity). Conclusions: Our study indicated that an increased SII index was closely related to PSCI at 3 months in patients with ischemic stroke. Further research is required to evaluate the efficacy of inflammation management in these patients. MDPI 2023-03-09 /pmc/articles/PMC10046597/ /pubmed/36979274 http://dx.doi.org/10.3390/brainsci13030464 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bao, Yuanfei
Wang, Lingling
Du, Chaopin
Ji, Yan
Dai, Yiwei
Jiang, Wei
Association between Systemic Immune Inflammation Index and Cognitive Impairment after Acute Ischemic Stroke
title Association between Systemic Immune Inflammation Index and Cognitive Impairment after Acute Ischemic Stroke
title_full Association between Systemic Immune Inflammation Index and Cognitive Impairment after Acute Ischemic Stroke
title_fullStr Association between Systemic Immune Inflammation Index and Cognitive Impairment after Acute Ischemic Stroke
title_full_unstemmed Association between Systemic Immune Inflammation Index and Cognitive Impairment after Acute Ischemic Stroke
title_short Association between Systemic Immune Inflammation Index and Cognitive Impairment after Acute Ischemic Stroke
title_sort association between systemic immune inflammation index and cognitive impairment after acute ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046597/
https://www.ncbi.nlm.nih.gov/pubmed/36979274
http://dx.doi.org/10.3390/brainsci13030464
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