Cargando…
High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters
Pulmonary fibrosis (PF) is an interstitial lung disease characterized by the destruction of the pulmonary parenchyma caused by excessive extracellular matrix deposition. Despite the well-known etiological factors such as senescence, aberrant epithelial cell and fibroblast activation, and chronic inf...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046645/ https://www.ncbi.nlm.nih.gov/pubmed/36979493 http://dx.doi.org/10.3390/biom13030558 |
_version_ | 1785013725252550656 |
---|---|
author | Yang, Juntang Liang, Chenxi Liu, Lulu Wang, Lan Yu, Guoying |
author_facet | Yang, Juntang Liang, Chenxi Liu, Lulu Wang, Lan Yu, Guoying |
author_sort | Yang, Juntang |
collection | PubMed |
description | Pulmonary fibrosis (PF) is an interstitial lung disease characterized by the destruction of the pulmonary parenchyma caused by excessive extracellular matrix deposition. Despite the well-known etiological factors such as senescence, aberrant epithelial cell and fibroblast activation, and chronic inflammation, PF has recently been recognized as a metabolic disease and abnormal lipid signature was observed both in serum and bronchoalveolar lavage fluid (BALF) of PF patients and mice PF model. Clinically, observational studies suggest a significant link between high-fat diet (HFD) and PF as manifested by high intake of saturated fatty acids (SFAs) and meat increases the risk of PF and mice lung fibrosis. However, the possible mechanisms between HFD and PF remain unclear. In the current review we emphasize the diversity effects of the epigenetic dysregulation induced by HFD on the fibrotic factors such as epithelial cell injury, abnormal fibroblast activation and chronic inflammation. Finally, we discuss the potential ways for patients to improve their conditions and emphasize the prospect of targeted therapy based on epigenetic regulation for scientific researchers or drug developers. |
format | Online Article Text |
id | pubmed-10046645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100466452023-03-29 High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters Yang, Juntang Liang, Chenxi Liu, Lulu Wang, Lan Yu, Guoying Biomolecules Review Pulmonary fibrosis (PF) is an interstitial lung disease characterized by the destruction of the pulmonary parenchyma caused by excessive extracellular matrix deposition. Despite the well-known etiological factors such as senescence, aberrant epithelial cell and fibroblast activation, and chronic inflammation, PF has recently been recognized as a metabolic disease and abnormal lipid signature was observed both in serum and bronchoalveolar lavage fluid (BALF) of PF patients and mice PF model. Clinically, observational studies suggest a significant link between high-fat diet (HFD) and PF as manifested by high intake of saturated fatty acids (SFAs) and meat increases the risk of PF and mice lung fibrosis. However, the possible mechanisms between HFD and PF remain unclear. In the current review we emphasize the diversity effects of the epigenetic dysregulation induced by HFD on the fibrotic factors such as epithelial cell injury, abnormal fibroblast activation and chronic inflammation. Finally, we discuss the potential ways for patients to improve their conditions and emphasize the prospect of targeted therapy based on epigenetic regulation for scientific researchers or drug developers. MDPI 2023-03-18 /pmc/articles/PMC10046645/ /pubmed/36979493 http://dx.doi.org/10.3390/biom13030558 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yang, Juntang Liang, Chenxi Liu, Lulu Wang, Lan Yu, Guoying High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters |
title | High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters |
title_full | High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters |
title_fullStr | High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters |
title_full_unstemmed | High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters |
title_short | High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters |
title_sort | high-fat diet related lung fibrosis-epigenetic regulation matters |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046645/ https://www.ncbi.nlm.nih.gov/pubmed/36979493 http://dx.doi.org/10.3390/biom13030558 |
work_keys_str_mv | AT yangjuntang highfatdietrelatedlungfibrosisepigeneticregulationmatters AT liangchenxi highfatdietrelatedlungfibrosisepigeneticregulationmatters AT liululu highfatdietrelatedlungfibrosisepigeneticregulationmatters AT wanglan highfatdietrelatedlungfibrosisepigeneticregulationmatters AT yuguoying highfatdietrelatedlungfibrosisepigeneticregulationmatters |