Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types

SIMPLE SUMMARY: Epithelial tissues are the most common sites for the development of cancer. Loss of epithelial cell characteristics and dedifferentiation are hallmarks of cancer. A specialized and complex function in epithelial cells is receptor-mediated endocytosis. LRP2 (megalin) is the largest kn...

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Detalles Bibliográficos
Autores principales: Rasmussen, Martin Q., Tindbæk, Gitte, Nielsen, Morten Muhlig, Merrild, Camilla, Steiniche, Torben, Pedersen, Jakob Skou, Moestrup, Søren K., Degn, Søren E., Madsen, Mette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046670/
https://www.ncbi.nlm.nih.gov/pubmed/36980716
http://dx.doi.org/10.3390/cancers15061830

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