Cargando…

A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze

Learning and memory deficits accompany numerous brain dysfunctions, including schizophrenia and Alzheimer’s disease (AD), and many studies point to the role of nitric oxide (NO) in these processes. The present investigations constitute the follow-up of our previous research, in which we investigated...

Descripción completa

Detalles Bibliográficos
Autores principales: Cieślik, Paulina, Borska, Magdalena, Wierońska, Joanna Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046674/
https://www.ncbi.nlm.nih.gov/pubmed/36979220
http://dx.doi.org/10.3390/brainsci13030410
_version_ 1785013732361895936
author Cieślik, Paulina
Borska, Magdalena
Wierońska, Joanna Monika
author_facet Cieślik, Paulina
Borska, Magdalena
Wierońska, Joanna Monika
author_sort Cieślik, Paulina
collection PubMed
description Learning and memory deficits accompany numerous brain dysfunctions, including schizophrenia and Alzheimer’s disease (AD), and many studies point to the role of nitric oxide (NO) in these processes. The present investigations constitute the follow-up of our previous research, in which we investigated the activity of NO releasers and a selective inhibitor of neuronal NO synthase (nNOS) to prevent short-term memory deficits in novel object recognition and T-maze. Here, the ability of the compounds to prevent the induction of long-term memory deficits by MK-801 or scopolamine administration was investigated. The Morris Water Maze test, a reliable and valid test of spatial learning and memory, was used, in which escape latency in the acquisition phase and nine different parameters in the retention phase were measured. A fast NO releaser (spermine NONOate), a slow NO releaser (DETA NONOate), and a nNOS inhibitor, N(ω)-propyl-L-arginine (NPLA), were used. The compounds were administered i.p. at a dose range of 0.05–0.5 mg/kg. All compounds prevented learning deficits in the acquisition phase and reversed reference memory deficits in the retention phase of the scopolamine-treated mice. Spermine NONOate was the least effective. In contrast, the drugs poorly antagonised MK-801-induced deficits, and only the administration of DETA NONOate induced some improvements in the retention trial.
format Online
Article
Text
id pubmed-10046674
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100466742023-03-29 A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze Cieślik, Paulina Borska, Magdalena Wierońska, Joanna Monika Brain Sci Article Learning and memory deficits accompany numerous brain dysfunctions, including schizophrenia and Alzheimer’s disease (AD), and many studies point to the role of nitric oxide (NO) in these processes. The present investigations constitute the follow-up of our previous research, in which we investigated the activity of NO releasers and a selective inhibitor of neuronal NO synthase (nNOS) to prevent short-term memory deficits in novel object recognition and T-maze. Here, the ability of the compounds to prevent the induction of long-term memory deficits by MK-801 or scopolamine administration was investigated. The Morris Water Maze test, a reliable and valid test of spatial learning and memory, was used, in which escape latency in the acquisition phase and nine different parameters in the retention phase were measured. A fast NO releaser (spermine NONOate), a slow NO releaser (DETA NONOate), and a nNOS inhibitor, N(ω)-propyl-L-arginine (NPLA), were used. The compounds were administered i.p. at a dose range of 0.05–0.5 mg/kg. All compounds prevented learning deficits in the acquisition phase and reversed reference memory deficits in the retention phase of the scopolamine-treated mice. Spermine NONOate was the least effective. In contrast, the drugs poorly antagonised MK-801-induced deficits, and only the administration of DETA NONOate induced some improvements in the retention trial. MDPI 2023-02-27 /pmc/articles/PMC10046674/ /pubmed/36979220 http://dx.doi.org/10.3390/brainsci13030410 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cieślik, Paulina
Borska, Magdalena
Wierońska, Joanna Monika
A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze
title A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze
title_full A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze
title_fullStr A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze
title_full_unstemmed A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze
title_short A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze
title_sort comparative study of the impact of no-related agents on mk-801- or scopolamine-induced cognitive impairments in the morris water maze
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046674/
https://www.ncbi.nlm.nih.gov/pubmed/36979220
http://dx.doi.org/10.3390/brainsci13030410
work_keys_str_mv AT cieslikpaulina acomparativestudyoftheimpactofnorelatedagentsonmk801orscopolamineinducedcognitiveimpairmentsinthemorriswatermaze
AT borskamagdalena acomparativestudyoftheimpactofnorelatedagentsonmk801orscopolamineinducedcognitiveimpairmentsinthemorriswatermaze
AT wieronskajoannamonika acomparativestudyoftheimpactofnorelatedagentsonmk801orscopolamineinducedcognitiveimpairmentsinthemorriswatermaze
AT cieslikpaulina comparativestudyoftheimpactofnorelatedagentsonmk801orscopolamineinducedcognitiveimpairmentsinthemorriswatermaze
AT borskamagdalena comparativestudyoftheimpactofnorelatedagentsonmk801orscopolamineinducedcognitiveimpairmentsinthemorriswatermaze
AT wieronskajoannamonika comparativestudyoftheimpactofnorelatedagentsonmk801orscopolamineinducedcognitiveimpairmentsinthemorriswatermaze